1,2-di-tert-butylpyrazolidine | 650600-24-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1,2-di-tert-butylpyrazolidine
• 英文别名: 1,2-ditert-butylpyrazolidine
• CAS: 650600-24-1
• 化学式: C₁₁H₂₄N₂
• 分子量: 184.325
• InChiKey: PHEWXTWFFPULJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2-di-tert-butylpyrazolidine 在 硫酸 作用下， 生成 1,2-di-tert-butylpyrazolidine hydrogen sulphate
  参考文献：
  名称：

  通过N反演的空间否决权获得氮手性

  摘要：

  合成了具有氮反转的位阻（4，6，7）或阻滞（5，8）的新型环状肼4–8。通过手性色谱法将吡唑基赖氨酸5分离为对映体。通过X射线衍射分析研究了盐5a和5b的晶体结构。

  DOI：

  10.1070/mc2003v013n03abeh001751
• 作为产物：
  描述：

  1,2-di-tert-butylhydrazine 在 甲酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 生成 1,2-di-tert-butylpyrazolidine
  参考文献：
  名称：

  通过N反演的空间否决权获得氮手性

  摘要：

  合成了具有氮反转的位阻（4，6，7）或阻滞（5，8）的新型环状肼4–8。通过手性色谱法将吡唑基赖氨酸5分离为对映体。通过X射线衍射分析研究了盐5a和5b的晶体结构。

  DOI：

  10.1070/mc2003v013n03abeh001751

文献信息

• QUENCHER
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：US20170342031A1

  公开（公告）日：2017-11-30

  A quencher is disclosed having a compound represented by the following general formula (1): wherein R 5 each independently represent a halogen atom, an alkyl group, an alkoxy group, an alkylthio group, an amino group having a substituent or not having a substituent, a hydroxy group, an aryl group, an aryloxy group, or an arylalkyl group; R 6 represents a group having a polymerizable unsaturated group, a hydroxy group, or the like; Y 1 represents an oxygen atom, or the like; An − represents an anion; Ar 1 represents a specific ring structure; * and ** represent binding positions; Ar 2 represents a benzene ring, a naphthalene ring, or an anthracene ring; n 1 represents a specific integer; and the following structure (1-10) in the general formula (1) is an asymmetric structure; (wherein R 5 , Y 1 , Ar 1 , Ar 2 , n 1 , * and ** are the same as described above.).

  一种淬灭剂被公开，该淬灭剂具有以下一般公式(1)表示的化合物： 其中R5各自独立代表一个卤素原子、一个烷基团、一个烷氧基团、一个烷硫基团、一个带有或不带有取代基的氨基团、一个羟基、一个芳基团、一个芳氧基团或一个芳烷基团；R6代表一个具有可聚合不饱和基团、一个羟基或类似基团的集团；Y1代表一个氧原子或类似；An代表一个阴离子；Ar1代表一个特定的环结构；*和**代表结合位置；Ar2代表一个苯环、一个萘环或一个蒽环；n1代表一个特定的整数； 并且一般公式(1)中的以下结构(1-10)是一个不对称结构； (其中R5、Y1、Ar1、Ar2、n1、*和**与上述描述相同)。
• RHODAMINE-BASED COLORING COMPOSITION
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：US20170145216A1

  公开（公告）日：2017-05-25

  A colored resin composition using a conventional rhodamine derivative has not provided heat resistance in a practical range. Therefore, it is an object of the present invention to provide a coloring composition having higher heat resistance as compared with the conventional coloring composition. The present invention relates to a compound represented by the following general formula (1), and a polymer having a monomer unit derived from the compound, and the like. (wherein R 1 to R 4 each independently represent a hydrogen atom, an alkyl group, and the like; R 7 represents a hydrogen atom or a methyl group; R 8 and R 9 each independently represent a hydrogen atom or an alkyl group; Y represents a nitrogen atom or a group represented by the following formula (1-1): A 1 represents an alkylene group which has at least one group selected from —O—, —OCO—, —COO—, —NHCO—, —CONH—, —NHCONH— and an arylene group in the chain, and the like; A 2 represents —NH— or —O—; An − represents an anion containing an aryl group having an electron-withdrawing substituent, and the like; n represents an integer of 0 to 3; R 8 and R 9 may form a cyclic structure of a 5 to 6 membered ring together with —N—(CH 2 ) n —Y— bonding thereto.)

  使用传统的罗丹明衍生物的有色树脂组合物在实际范围内未提供耐热性。因此，本发明的目的是提供一种比传统着色组合物具有更高耐热性的着色组合物。本发明涉及由以下通式（1）所代表的化合物，以及具有源自该化合物的单体单位的聚合物等。（其中R1至R4分别独立地代表氢原子、烷基基团等；R7代表氢原子或甲基基团；R8和R9分别独立地代表氢原子或烷基基团；Y代表氮原子或由以下式（1-1）所代表的基团：A1代表在链中至少具有一种从—O—，—OCO—，—COO—，—NHCO—，—CONH—，—NHCONH—和芳基基团中选择的基团的亚烷基基团等；A2代表—NH—或—O—；An−代表含有具有电子吸引取代基的芳基团的阴离子等；n表示0至3的整数；R8和R9可以与结合其的—N—（CH2）n—Y—共同形成5至6元环的环状结构。）
• Reverse photochromic compound
  申请人：FUJIFILM Wako Pure Chemical Corporation

  公开号：US10696898B2

  公开（公告）日：2020-06-30

  A reverse photochromic compound of the related art has difficulty in sensing light with a wavelength of 600 nm or greater in a visible light region which has been used for medical applications. Therefore, an object of the present invention is to provide a reverse photochromic compound and a polymer which have a high sensitivity to light having a wavelength of 600 nm or greater. The present invention relates to a compound and the like represented by the following general formula (1). In the formula, R1 and R4 each independently represent a hydrogen atom or the like, R2, R3, and R5 each independently represent an alkyl group or the like, R6 represents a group having a polymerizable unsaturated group, a carboxy group, or an alkoxycarbonyl group, R31 and R32 each independently represent an alkoxy group or the like, R33 and R34 each independently represent a hydrogen atom or the like, Y1 represents an oxygen atom or a sulfur atom, An− represents an anion, n1 to n3 represent a specific integer, and R1 and R2, R3 and R4, and/or R33 and R34 may form an alkylene group.

  相关技术中的一种反向光致变色化合物难以感应波长为 600 nm 或更长的可见光区域的光，而这种光一直被用于医疗用途。因此，本发明的目的是提供一种反向光致变色化合物和聚合物，它们对波长为 600 nm 或更大的光具有高灵敏度。本发明涉及由以下通式（1）表示的化合物及类似物。 式中，R1 和 R4 各自独立地代表氢原子或类似物，R2、R3 和 R5 各自独立地代表烷基或类似物，R6 代表具有可聚合的不饱和基团、羧基或烷氧基羰基的基团、R31 和 R32 各自独立地代表烷氧基或类似基团，R33 和 R34 各自独立地代表氢原子或类似基团，Y1 代表氧原子或硫原子，An- 代表阴离子，n1 至 n3 代表特定整数，R1 和 R2、R3 和 R4 和/或 R33 和 R34 可形成亚烷基。
• GRAFT POLYMER, RESIN COLORED MATTER, METHOD FOR PRODUCING SAME, AND RESIN COMPOSITION CONTAINING RESIN COLORED MATTER
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：US20170137553A1

  公开（公告）日：2017-05-18

  The present invention relates to: (1) a graft polymer that has a polyolefin (A) as the main chain, and a polymer (B) polymerized a dye (b) having a radical reactive functional group, in a side chain; (2) the graft polymer which is characterized in that the dye (b) having the radical reactive functional group is a cationic rhodamine derivative, a cationic triarylmethane-type dye derivative or a cationic cyanine-type dye derivative, having an ethylenically unsaturated group; (3) a colored resin consisting of the graft polymer; as well as (4) a method for producing the colored resin, which is characterized by mixing the polyolefin (A), the dye (b) having the radical reactive functional group, and the radical reaction initiator (C), and subjecting a radical reaction of the mixture; and the like.
• NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS
  申请人：Jacobio Pharmaceuticals Co., Ltd.

  公开号：US20200392128A1

  公开（公告）日：2020-12-17

  This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.