5-methyl-2H-dibenz[cd,g]indazol-6-one | 593249-10-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 5-methyl-2H-dibenz[cd,g]indazol-6-one
• 英文别名: 5-Methyl-2H-dibenz[cd,g]indazol-6-on；5-methyl-2,6-dihydrodibenzo[cd,g]indazol-6-one；10-methyl-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9,11,13(16)-heptaen-8-one
• CAS: 593249-10-6
• 化学式: C₁₅H₁₀N₂O
• 分子量: 234.257
• InChiKey: BPXBVDLTICYNCH-UHFFFAOYSA-N

物化性质

• 沸点：
  506.1±29.0 °C(Predicted)
• 密度：
  1.404±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  45.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-methyl-2H-dibenz[cd,g]indazol-6-one 在 N-溴代丁二酰亚胺(NBS) 、 sodium azide 、 硫酸 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 30.5h， 生成 3-bromo-5-methyl-6,7-dihydro-2H-benzo[5,6]azepino[4,3,2-cd]indazol-7-one
  参考文献：
  名称：

  NOVEL FUSED RING INDAZOLE COMPOUNDS

  摘要：

  公开号：

  EP1479670B1
• 作为产物：
  描述：

  1-hydrazino-4-methyl-anthraquinone 在 aniline hydrochloride 、 苯胺 作用下， 生成 5-methyl-2H-dibenz[cd,g]indazol-6-one
  参考文献：
  名称：

  Mayer; Heil, Chemische Berichte, 1922, vol. 55, p. 2163

  摘要：

  DOI：

文献信息

• Novel fused indazole compounds
  申请人：Ohi Norihito

  公开号：US20060111419A1

  公开（公告）日：2006-05-25

  The present invention provides a novel fused indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein Z 11 and Z 12 each independently represent a carbonyl group, a methylene group, etc.; represents a double bond or a single bond; R 1a represents a hydrogen atom, etc.; the ring A represents a benzene ring, a naphthalene ring or a 5- to 10-membered aromatic heterocyclic ring, etc.; and R 2a , R 2b and R 2c each independently represent (1) a hydrogen atom, (2) a halogen atom, (3) a nitro group, etc.

  本发明提供了一种具有出色的JNK抑制作用的新型融合吲唑化合物。更具体地，它提供了以下式子所表示的化合物，其盐或水合物。其中Z11和Z12各自独立地表示羰基基团、亚甲基基团等；表示双键或单键；R1a表示氢原子等；环A表示苯环、萘环或5-至10-成员芳香杂环环等；R2a、R2b和R2c各自独立地表示(1)氢原子、(2)卤原子、(3)硝基等。
• Fused indazole compounds
  申请人：Eisai Co., Ltd.

  公开号：US07390797B2

  公开（公告）日：2008-06-24

  The present invention provides a novel fused indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein Z11 and Z12 each independently represent a carbonyl group, a methylene group, etc.; represents a double bond or a single bond; R1a represents a hydrogen atom, etc.; the ring A represents a benzene ring, a naphthalene ring or a 5- to 10-membered aromatic heterocyclic ring, etc.; and R2a, R2b and R2c each independently represent (1) a hydrogen atom, (2) a halogen atom, (3) a nitro group, etc.

  本发明提供了一种新型的融合吲唑化合物，具有出色的JNK抑制作用。更具体地说，它提供了以下式子所表示的化合物，其盐或其水合物：其中Z11和Z12各自独立地表示羰基基团、亚甲基基团等；表示双键或单键；R1a表示氢原子等；环A表示苯环、萘环或5-至10-成员芳香杂环等；而R2a、R2b和R2c各自独立地表示（1）氢原子，（2）卤素原子，（3）硝基等。
• DE301554
  申请人：——

  公开号：——

  公开（公告）日：——
• Therapeutic Methods for Type I Diabetes
  申请人：UNIVERSITY OF MASSACHUSETTS

  公开号：US20150313881A1

  公开（公告）日：2015-11-05

  The invention relates to the treatment and prevention of type I diabetes. More specifically, the invention relates to compounds that treat or prevent the body's immune system from destroying β-cells (i.e., insulin-producing cells in the pancreatic islets of Langerhans) by inhibition of JNK2, selective inhibition of JNK2, or inhibition of the expression of the MAPK9 gene or gene product. In one embodiment, the present invention contemplates the diagnosis, identification, production, and use of compounds which modulate MAPK9 gene expression or the activity of the MAPK9 gene product including but not limited to, JNK2, the nucleic acid encoding MAPK9 and homologues, analogues, and deletions thereof, as well as antisense, ribozyme, triple helix, antibody, and polypeptide molecules as well as small inorganic molecules. The present invention contemplates a variety of pharmaceutical formulations and routes of administration for such compounds.
• US7335676B2
  申请人：——

  公开号：US7335676B2

  公开（公告）日：2008-02-26