4-{[(E)-(5-chloro-2-hydroxyphenyl)methylidene]amino}-N-(5-methylisoxazol-3-yl)benzenesulfonamide | 1374604-65-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-{[(E)-(5-chloro-2-hydroxyphenyl)methylidene]amino}-N-(5-methylisoxazol-3-yl)benzenesulfonamide
• CAS: 1374604-65-5
• 化学式: C₁₇H₁₄ClN₃O₄S
• 分子量: 391.835
• InChiKey: FFLCEJMNABKQLE-VXLYETTFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.89
• 重原子数：
  26.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  104.79
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  磺胺甲恶唑 、 5-氯代水杨醛 以 乙醇 为溶剂， 反应 3.0h， 以85%的产率得到4-{[(E)-(5-chloro-2-hydroxyphenyl)methylidene]amino}-N-(5-methylisoxazol-3-yl)benzenesulfonamide
  参考文献：
  名称：

  Metal-based new sulfonamides: Design, synthesis, antibacterial, antifungal, and cytotoxic properties

  摘要：

  Cobalt(II), copper(II), nickel(II) and zinc(II) metal complexes with 5-chlorosalicyladehyde derived Schiff base sulfonamides have been synthesized and characterized. Structure and bonding nature of all the synthesized compounds have been deduced from physical, analytical, and spectral (IR, H-1 NMR, C-13 NMR, Mass, electronic) data. An octahedral geometry has been proposed for all the metal complexes. The ligands and their metal complexes have been screened for their in vitro antibacterial, antifungal, and cytotoxic properties and results are reported.

  DOI：

  10.3109/14756366.2011.593515

文献信息

• Metal-based new sulfonamides: Design, synthesis, antibacterial, antifungal, and cytotoxic properties
  作者：Zahid H. Chohan、Hazoor A. Shad

  DOI：10.3109/14756366.2011.593515

  日期：2012.6.1

  Cobalt(II), copper(II), nickel(II) and zinc(II) metal complexes with 5-chlorosalicyladehyde derived Schiff base sulfonamides have been synthesized and characterized. Structure and bonding nature of all the synthesized compounds have been deduced from physical, analytical, and spectral (IR, H-1 NMR, C-13 NMR, Mass, electronic) data. An octahedral geometry has been proposed for all the metal complexes. The ligands and their metal complexes have been screened for their in vitro antibacterial, antifungal, and cytotoxic properties and results are reported.