1-(2,6-diisopropylphenyl)-3-(2-methylphenyl)-imidazolinium chloride | 1025068-46-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,6-diisopropylphenyl)-3-(2-methylphenyl)-imidazolinium chloride
• 英文别名: 1-(2,6-diisopropylphenyl)-3-(2-methylphenyl)imidazolinium chloride；1-[2,6-Di(propan-2-yl)phenyl]-3-(2-methylphenyl)-4,5-dihydroimidazol-1-ium;chloride
• CAS: 1025068-46-5
• 化学式: C₂₂H₂₉N₂*Cl
• 分子量: 356.939
• InChiKey: PFDBMIZQEANLRB-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.44
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  6.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(2,6-diisopropylphenyl)-3-(2-methylphenyl)-imidazolinium chloride 、 palladium diacetate 在 sodium acetate 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 以78%的产率得到di-μ-chloro-bis{2-[3-(2,6-diisopropylphenyl)imidazolin-2-ylidene]-3-methylphenyl-κ²C,C’}dipalladium(II)
  参考文献：
  名称：

  甲醛水溶液对芳基和杂芳基硼酸进行钯催化的羟甲基化

  摘要：

  AbstractCyclometallated NHC palladium complexes prepared from palladium(II) acetate [Pd(OAc)2] and unsymmetrical 1,3‐diarylimidazolinium salts catalyzed the hydroxymethylation of (hetero)arylboronic acids using an excess amount of formalin to afford (hetero)arylmethanols in good to satisfactory yields.magnified image

  DOI：

  10.1002/adsc.201400845
• 作为产物：
  描述：

  N-(2,6-diisopropylphenyl)-N'-(2-methylphenyl)formamidine 、 1,2-二氯乙烷 反应 36.0h， 以43%的产率得到1-(2,6-diisopropylphenyl)-3-(2-methylphenyl)-imidazolinium chloride
  参考文献：
  名称：

  [EN] PREPARATION OF SATURATED IMIDAZOLINIUM SALTS AND RELATED COMPOUNDS
  [FR] PRÉPARATION DE SELS D'IMIDAZOLINIUM SATURÉS ET COMPOSÉS ASSOCIÉS

  摘要：

  公开了用于制备饱和咪唑啉盐和相关化合物的方法，包括将甲酰胺与二硫乙烷等化合物发生反应以及可选的碱。另外，咪唑盐和相关化合物也可以在一步过程中制备，无需纯化甲酰胺反应物。这些方法使得在无溶剂反应条件下且产率极高的情况下获得大量咪唑啉盐和相关化合物成为可能。

  公开号：

  WO2009062171A1

文献信息

• PREPARATION OF SATURATED IMIDAZOLINIUM SALTS AND RELATED COMPOUNDS
  申请人：Kuhn Kevin

  公开号：US20110087032A1

  公开（公告）日：2011-04-14

  Methods for the preparation of saturated imidazolinium salts and related compounds that comprises reaction of formamidines with compounds such as dihaloethane and an optional base are disclosed. Alternatively, the imidazolinium salts and related compounds can be prepared in a one-step process without purification of the formamidine reactant. These methods make it possible to obtain numerous imidazolinium salts and related compounds under solvent-free reaction conditions and in excellent yields.

  本发明公开了一种制备饱和咪唑啉盐和相关化合物的方法，包括将甲酰胺与二卤乙烷等化合物反应，并可选用碱。另外，咪唑啉盐和相关化合物也可以在一步反应过程中制备，而无需净化甲酰胺反应物。这些方法使得在无溶剂反应条件下，以优异的产率获得众多咪唑啉盐和相关化合物成为可能。
• A Facile Preparation of Imidazolinium Chlorides
  作者：Kevin M. Kuhn、Robert H. Grubbs

  DOI：10.1021/ol800628a

  日期：2008.5.1

  A process for the preparation of symmetric and unsymmetric imidazolinium chlorides that involves reaction of a formamidine with dichloroethane and a base (a) is described. This method makes it possible to obtain numerous imidazolinium chlorides under solvent-free reaction conditions and in excellent yields with purification by simple filtration. Alternatively, symmetric imidazolinium chlorides can be prepared directly in moderate yields from substituted anilines by utilizing half of the formamidine intermediate as sacrificial base (b).
• US8703965B2
  申请人：——

  公开号：US8703965B2

  公开（公告）日：2014-04-22
• Palladium-Catalyzed Hydroxymethylation of Aryl- and Heteroarylboronic Acids using Aqueous Formaldehyde
  作者：Tetsuya Yamamoto、Azamat Zhumagazin、Takuma Furusawa、Ryoji Tanaka、Tetsu Yamakawa、Yohei Oe、Tetsuo Ohta

  DOI：10.1002/adsc.201400845

  日期：2014.11.24

  AbstractCyclometallated NHC palladium complexes prepared from palladium(II) acetate [Pd(OAc)2] and unsymmetrical 1,3‐diarylimidazolinium salts catalyzed the hydroxymethylation of (hetero)arylboronic acids using an excess amount of formalin to afford (hetero)arylmethanols in good to satisfactory yields.magnified image
• [EN] PREPARATION OF SATURATED IMIDAZOLINIUM SALTS AND RELATED COMPOUNDS<br/>[FR] PRÉPARATION DE SELS D'IMIDAZOLINIUM SATURÉS ET COMPOSÉS ASSOCIÉS
  申请人：MATERIA INC

  公开号：WO2009062171A1

  公开（公告）日：2009-05-14

  Methods for the preparation of saturated imidazolinium salts and related compounds that comprises reaction of formamidines with compounds such as dihaioethane and an optional base are disclosed. Alternatively, the imidazoünium salts and related compounds can be prepared in a one-step process without purification of the formamidine reactant. These methods make it possible to obtain numerous imidazolinium salts and related compounds under solvent-free reaction conditions and in excellent yields.

  公开了用于制备饱和咪唑啉盐和相关化合物的方法，包括将甲酰胺与二硫乙烷等化合物发生反应以及可选的碱。另外，咪唑盐和相关化合物也可以在一步过程中制备，无需纯化甲酰胺反应物。这些方法使得在无溶剂反应条件下且产率极高的情况下获得大量咪唑啉盐和相关化合物成为可能。