4,5α-epoxy-3-methoxy-17-methyl-morphinan-6α-ol | 125-28-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 4,5α-epoxy-3-methoxy-17-methyl-morphinan-6α-ol
• 英文别名: Dihydrocodein；(-)-dihydrocodeine；dihydrocodeine；(4R,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
• CAS: 125-28-0；795-38-0；28379-49-9；29699-74-9；144408-29-7
• 化学式: C₁₈H₂₃NO₃
• 分子量: 301.386
• InChiKey: RBOXVHNMENFORY-SQXROVMKSA-N

物化性质

• 熔点：
  199-200°
• 溶解度：
  可溶于氯仿（轻微，超声处理）、DMSO（轻微）、乙酸乙酯（轻微）

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2939110012

文献信息

• 6-Monoacetylmorphine derivatives useful in immunoassay
  申请人：Ghoshal Mitali

  公开号：US20070142628A1

  公开（公告）日：2007-06-21

  Analogs of 6-monoacetyl morphine (6-MAM) are described. These include analogs derivatized at either the C-3 position, the C-6 position, or the nor position of the molecule. These analogs allow for elaboration with linkers terminated by a functional group such as an activated ester, the functional groups being useful for attaching the molecule to other entities such as proteins, polysaccharides, and reporter groups.

  6-单乙酰吗啡（6-MAM）类似物如下所述。这些包括在分子的C-3位置、C-6位置或去甲位置进行衍生的类似物。这些类似物允许进行以活化酯等功能团终止的连接剂的详细说明，这些功能团对于将分子附着到其他实体（如蛋白质、多糖和报告团）非常有用。
• 6-monoacetylmorphine derivatives useful in immunoassay
  申请人：Roche Diagnostics GmbH

  公开号：EP1810973A1

  公开（公告）日：2007-07-25

  Analogs of 6-monoacetyl morphine (6-MAM) are described. These include analogs derivatized at either the C-3 position, the C-6 position, or the nor position of the molecule. These analogs allow for elaboration with linkers terminated by a functional group such as an activated ester, the functional groups being useful for attaching the molecule to other entities such as proteins, polysaccharides, and reporter groups.

  6-单乙酰吗啡（6-MAM）的类似物被描述。这些包括在分子的C-3位置、C-6位置或去甲位置进行衍生的类似物。这些类似物允许通过以活化酯等功能团终止的连接剂进行扩展，这些功能团对于将分子附着到其他实体（如蛋白质、多糖和报告基团）非常有用。
• Process for the Preparation of 6-Alpha-Hydroxy-N-Alkylated Opiates
  申请人：Grote Christopher W.

  公开号：US20100041888A1

  公开（公告）日：2010-02-18

  The present invention is directed to the conversion of a 6-keto morphinan to a 6-alpha-hydroxy morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.

  本发明涉及在存在钌、铑或铱不对称催化剂和氢源的情况下将6-酮基吗啡酮转化为6-α-羟基吗啡酮。
• Oligomer-Opioid Agonist Conjugates
  申请人：Riggs-Sauthier Jennifer

  公开号：US20120184581A1

  公开（公告）日：2012-07-19

  The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

  本发明提供了通过共价连接水溶性寡聚体进行化学修饰的化合物。本发明的化合物在通过多种给药途径之一给予时，表现出与未连接水溶性寡聚体的化合物不同的特性。
• OLIGOMER-OPIOID AGONIST CONJUGATES
  申请人：NEKTAR THERAPEUTICS

  公开号：US20150112069A1

  公开（公告）日：2015-04-23

  The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

  该发明提供了通过共价连接水溶性寡聚体进行化学修饰的化合物。该发明的化合物在通过多种给药途径给予时，表现出与未连接水溶性寡聚体的化合物不同的特性。