5-(4-氨基丁基氨基甲基)尿嘧啶 | 40451-54-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 5-(4-氨基丁基氨基甲基)尿嘧啶
• 英文名称: alpha-Putrescinylthymine
• 英文别名: 5-[(4-aminobutylamino)methyl]-1H-pyrimidine-2,4-dione
• CAS: 40451-54-5
• 化学式: C₉H₁₆N₄O₂
• 分子量: 212.25
• InChiKey: IBOLVNKLOOYDDG-UHFFFAOYSA-N

物化性质

• 密度：
  1.163±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  96.2
• 氢给体数：
  4
• 氢受体数：
  4

安全信息

• 海关编码：
  2933599090

文献信息

• Genomic library of cyanophage s-2l and functional analysis
  申请人：Marliere Philippe

  公开号：US20060270005A1

  公开（公告）日：2006-11-30

  The invention relates to the genome sequence and the nucleotide sequences coding for polypeptides of cyanophage S-2L. According to the invention, the polypeptides include, but are not limited to, polypeptides involved in the synthesis, transcription and replication of purine bases. In particular, determining the genome of cyanophage S-2L is useful for supplying genes which, expressed in recombinant bacteria, enable the synthesis of DNA monomers incorporating base D (2,6 diaminopurine instead of base A (adenine), thereby producing chemically-remodelled nucleic acids in the bacteria.

  该发明涉及青藻噬菌体S-2L的基因组序列和编码多肽的核苷酸序列。根据该发明，这些多肽包括但不限于参与嘌呤碱基的合成、转录和复制的多肽。特别是，确定青藻噬菌体S-2L的基因组对于提供在重组细菌中表达的基因是有用的，这些基因能够合成包含碱基D（2,6-二氨基嘌呤而不是腺嘌呤）的DNA单体，从而在细菌中产生化学重塑的核酸。
• A method of inducing antitumor immunocytes, and a process for producing antitumor immunocytes and antitumor immunocytes produced by the process
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0147689A2

  公开（公告）日：1985-07-10

  A method of inducing antitumor immunocytes which is simple in operation and suitable for inducing antitumor immunocytes having not only excellent cytotoxic activity against tumor cells but also high safety, which method comprises contacting leucocytes with an insoluble, antitumor immunocyte-inducing material capable of linking with T cells, said antitumor immunocyte-inducing material comprising an insoluble carrier and a ligand linked therewith. The induced antitumor immunocytes can be simply separated in substantially ligand-free form from the insoluble, antitumor immunocyte-inducing material. The obtained antitumor immunocytes have not only excellent cytotoxic activity against tumor cells but also high safety.

  一种诱导抗肿瘤免疫细胞的方法，该方法操作简单，适用于诱导抗肿瘤免疫细胞，不仅对肿瘤细胞具有优异的细胞毒活性，而且安全性高，该方法包括使白细胞与不溶性的、能与 T 细胞连接的抗肿瘤免疫细胞诱导材料接触，所述抗肿瘤免疫细胞诱导材料包括不溶性载体和与之连接的配体。 可以简单地将诱导的抗肿瘤免疫细胞以基本上不含配体的形式从不溶性的抗肿瘤免疫细胞诱导材料中分离出来。 获得的抗肿瘤免疫细胞不仅对肿瘤细胞具有优异的细胞毒活性，而且安全性高。
• Osmiumtetroxide-based conversion of RNA and DNA containing thiolated nucleotides
  申请人：UNIVERSITY OF INNSBRUCK

  公开号：US11254982B2

  公开（公告）日：2022-02-22

  Provided are compositions and methods for the conversion of thiolated nucleotides, and subsequent detection of the converted nucleotides in RNA or DNA. Also provided herein are compositions and methods for the metabolic labeling of RNA and DNA by incorporation of thiolated nucleotides, and their subsequent conversion and detection.

  本文提供了硫醇化核苷酸转化以及随后检测 RNA 或 DNA 中转化核苷酸的组合物和方法。本文还提供了通过掺入硫代核苷酸对 RNA 和 DNA 进行代谢标记以及随后对其进行转化和检测的组合物和方法。
• Target reporter constructs and uses thereof
  申请人：RedVault Biosciences, LP

  公开号：US11299769B2

  公开（公告）日：2022-04-12

  Provided herein are methods and compositions for the detection of target nucleic acids using target reporter constructs (TRCs) which comprise target sequences complementary to the target nucleic acid. Further provided are methods of replicating the TRCs using rolling circle replication and/or rolling circle amplification to produce replicated TRCs which can be detected using probe sequences within the replicated TRCs.

  本文提供了使用目标报告构建体（TRCs）检测目标核酸的方法和组合物，TRCs 包括与目标核酸互补的目标序列。此外，还提供了使用滚动圈复制和/或滚动圈扩增复制 TRCs 以产生复制的 TRCs 的方法，可使用复制的 TRCs 中的探针序列检测这些 TRCs。
• SYSTEMS AND METHODS FOR CLONAL REPLICATION AND AMPLIFICATION OF NUCLEIC ACID MOLECULES FOR GENOMIC AND THERAPEUTIC APPLICATIONS
  申请人：RedVault Biosciences LP

  公开号：EP3129505A1

  公开（公告）日：2017-02-15