2,6-diamino-5-(phenyldiazenyl)pyrimidin-4-ol | 3054-70-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,6-diamino-5-(phenyldiazenyl)pyrimidin-4-ol
• 英文别名: 2,6-Diamino-4-hydroxy-5-phenylazo-pyrimidin；5-Phenylazo-2,4-diamino-6-hydroxy-pyrimidin；2,4-Diamino-6-hydroxy-5-phenylazopyrimidin；2,6-diamino-pyrimidin-4,5-dione 5-phenylhydrazone；2,4-Diamino-6-hydroxy-5-phenylazopyrimidine；2,4-diamino-5-phenyldiazenyl-1H-pyrimidin-6-one
• CAS: 3054-70-4
• 化学式: C₁₀H₁₀N₆O
• 分子量: 230.229
• InChiKey: MUDXKPHUGKQTPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  、 胍 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以60%的产率得到2,6-diamino-5-(phenyldiazenyl)pyrimidin-4-ol
  参考文献：
  名称：

  Design, synthesis and biological evaluation of pyrimidine-based derivatives as antitumor agents

  摘要：

  In this paper we made a contentious effort to afford heterocyclic compounds with interesting biological activities. The reaction of guanidine with either activated methylene groups, arylhydrazono derivatives, dicyanopropene derivatives, malononitrile dimer or arylhydarazononitrile derivatives afforded diaminopyrimidine derivatives, aryldiazenyl pyrimidine derivatives, fused pyridopyrimidne derivatives and pyrimidopyridazine derivatives respectively.Also the reaction of guanidine with phenylhydrazono carbonyl compounds produced phenyldiazenyl pyrimidine derivatives. The latter products were directed toward the reaction with either acetic anhydride or ethylcyanoacetate to form acetamidopyrimidine derivatives and cyanoacetamidopyrimidine derivatives respectively. The latter products underwent cyclization via reaction with either activated methylene groups or activated methylene carbonyl compounds afforded pyridopyrimidne derivatives.The structures of the newly synthesized compounds were established using IR, H-1 NMR, C-13 NMR and mass spectrometry and their antitumor activity was investigated. Some of these compounds showed promising inhibitory effects on the three different cell lines.

  DOI：

  10.33224/rrch.2020.65.3.02

文献信息

• Studies on the series of azoles and azines. 66. Synthesis, spectra and structure of 5-arylazo- and 5-arylideneamino-2,4,6-triaminopyrimidines and their 6-hydroxy analogs
  作者：Zh. V. Belodedova、N. A. Smorygo、V. S. Mirzoyan、R. G. Melik-Orandzhanyan、E. P. Studentsov、B. A. Ivin

  DOI：10.1007/bf00755696

  日期：1988.5
• Design, synthesis and biological evaluation of pyrimidine-based derivatives as antitumor agents
  作者：Mohammed M. ALBRATTY、Karam A. El-SHARKAWY、Hassan A. AlHAZMI

  DOI：10.33224/rrch.2020.65.3.02

  日期：——

  In this paper we made a contentious effort to afford heterocyclic compounds with interesting biological activities. The reaction of guanidine with either activated methylene groups, arylhydrazono derivatives, dicyanopropene derivatives, malononitrile dimer or arylhydarazononitrile derivatives afforded diaminopyrimidine derivatives, aryldiazenyl pyrimidine derivatives, fused pyridopyrimidne derivatives and pyrimidopyridazine derivatives respectively.Also the reaction of guanidine with phenylhydrazono carbonyl compounds produced phenyldiazenyl pyrimidine derivatives. The latter products were directed toward the reaction with either acetic anhydride or ethylcyanoacetate to form acetamidopyrimidine derivatives and cyanoacetamidopyrimidine derivatives respectively. The latter products underwent cyclization via reaction with either activated methylene groups or activated methylene carbonyl compounds afforded pyridopyrimidne derivatives.The structures of the newly synthesized compounds were established using IR, H-1 NMR, C-13 NMR and mass spectrometry and their antitumor activity was investigated. Some of these compounds showed promising inhibitory effects on the three different cell lines.