4-[[1-(4-chlorobenzoyl)-3-methyl-5-oxo-4H-pyrazol-4-yl]diazenyl]-N-pyrimidin-2-ylbenzenesulfonamide | 1073232-83-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[[1-(4-chlorobenzoyl)-3-methyl-5-oxo-4H-pyrazol-4-yl]diazenyl]-N-pyrimidin-2-ylbenzenesulfonamide
• CAS: 1073232-83-3
• 化学式: C₂₁H₁₆ClN₇O₄S
• 分子量: 497.922
• InChiKey: HRJNALBHZAXUKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  155
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  磺胺嘧啶 在 盐酸 、 sodium acetate 、 溶剂黄146 、 sodium nitrite 作用下， 以 水 为溶剂， 生成 4-[[1-(4-chlorobenzoyl)-3-methyl-5-oxo-4H-pyrazol-4-yl]diazenyl]-N-pyrimidin-2-ylbenzenesulfonamide
  参考文献：
  名称：

  [EN] SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME
  [FR] INHIBITEURS DE PETITES MOLÉCULES DU DOMAINE D'HOMOLOGIE DE LA PLECKSTRINE, ET LEURS MÉTHODES D'UTILISATION

  摘要：

  公开号：

  WO2009129267A3

文献信息

• PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS INCLUDING INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME
  申请人：Kirkpatrick D. Lynn

  公开号：US20120189670A1

  公开（公告）日：2012-07-26

  Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.

  本文描述了与Pleckstrin同源结构域结合的化合物，包括这些化合物的药物组合物，以及其使用方法。
• SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME
  申请人：Board of Regents, The University of Texas System

  公开号：US20150126563A1

  公开（公告）日：2015-05-07

  Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.

  本文介绍了Pleckstrin homology domain binding compounds，包括这些化合物的制药组合物及其使用方法。
• Small molecule inhibitors of the pleckstrin homology domain and method for using same
  申请人：The Board of Regents of the University of Texas System

  公开号：EP2428504A1

  公开（公告）日：2012-03-14

  Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein

  本文描述了 Pleckstrin 同源结构域结合化合物、包括此类化合物的药物组合物及其使用方法
• Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof
  申请人：Degterev Alexei

  公开号：US20120136033A1

  公开（公告）日：2012-05-31

  Disclosed are a new class of non-lipid small molecule inhibitors which interfere with the interaction between PIP3 and pleckstrin homology domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided.
• US8628961B2
  申请人：——

  公开号：US8628961B2

  公开（公告）日：2014-01-14