2,3-diphenyl-1,3-thiazolidin-4-one-1,1-dioxide | 16470-69-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-diphenyl-1,3-thiazolidin-4-one-1,1-dioxide
• 英文别名: 1,1-dioxo-2,3-diphenyl-1λ⁶-thiazolidin-4-one；2,3-Diphenyl-4-oxo-tetrahydro-1,3-thiazol-1,1-dioxid；1-Sulfodioxy-1,3-diphenylthiazolidin-4-on；1-Sulfodioxy-2,3-diphenylthiazolidon-4；2,3-Diphenyl-1,3-thiazolidin-4-one 1,1-dioxide；1,1-dioxo-2,3-diphenyl-1,3-thiazolidin-4-one
• CAS: 16470-69-2
• 化学式: C₁₅H₁₃NO₃S
• 分子量: 287.339
• InChiKey: RQEIAMDCJRURGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,3-diphenyl-1,3-thiazolidin-4-one-1,1-dioxide 在 tetraphosphorus decasulfide 作用下， 以 间二甲苯 为溶剂， 生成 1-Sulfodioxy-2,3-diphenylthiazolidinthion-4
  参考文献：
  名称：

  Synthesis of 4-thionothiazolidine sulfones with potential antitubercular activity

  摘要：

  DOI：

  10.1007/bf00759815
• 作为产物：
  描述：

  2,3-二苯基噻唑烷-4-酮 在 potassium permanganate 、 溶剂黄146 作用下， 生成 2,3-diphenyl-1,3-thiazolidin-4-one-1,1-dioxide
  参考文献：
  名称：

  Synthetic Modification of 1,3-Thiazolidin-4-One 1,1-Dioxides

  摘要：

  The reactivity of EWG (electron withdrawing group)-activated methylene group in 1,3-thiazolidin-4-one 1,1-dioxides were investigated. Novel derivatives of 1,3-thiazolidin-4-one 1,1-dioxides were prepared (the heterocyclic core was modified with carboxamide and carboxthioamide moieties as carbonyl group analogues). The products, which have functional groups for possible future modifications, are described and characterized.

  DOI：

  10.1080/10426507.2013.787998

文献信息

• Incorporation of Sulfur Dioxide into the Products of Reaction ofSchiff Bases with Halo- or Alkylthio-ketenes in Liquid SO2. Preliminary communication
  作者：Daniel Bellu?

  DOI：10.1002/hlca.19750580832

  日期：1975.11.5

  A simple ‘three-component-reaction’ between halo- or alkylthio-ketenes, Schiff bases and sulfur dioxide, yielding 4-oxo-1,3-thiazolidine-1,1-dioxides 4 in one step, is presented.

  本文介绍了卤代或烷硫基乙烯酮，席夫碱和二氧化硫之间的简单“三组分反应”，可一步生成4-氧代-1,3-噻唑烷-1,1-二氧化物4。
• Baranov,S.N. et al., Soviet progress in chemistry, 1974, vol. 40, # 11, p. 43 - 47
  作者：Baranov,S.N. et al.

  DOI：——

  日期：——
• Synthesis of 4-thionothiazolidine sulfones with potential antitubercular activity
  作者：B. E. Zhitar、S. N. Baranov

  DOI：10.1007/bf00759815

  日期：1969.11
• Synthetic Modification of 1,3-Thiazolidin-4-One 1,1-Dioxides
  作者：Dymytrii Listunov、Kirill Popov、Yulian Volovenko、Sergiy Popov

  DOI：10.1080/10426507.2013.787998

  日期：2013.12.1

  The reactivity of EWG (electron withdrawing group)-activated methylene group in 1,3-thiazolidin-4-one 1,1-dioxides were investigated. Novel derivatives of 1,3-thiazolidin-4-one 1,1-dioxides were prepared (the heterocyclic core was modified with carboxamide and carboxthioamide moieties as carbonyl group analogues). The products, which have functional groups for possible future modifications, are described and characterized.