imatinib oxalate | 1157849-77-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: imatinib oxalate
• 英文别名: 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide;oxalic acid
• CAS: 1157849-77-8
• 化学式: C₂H₂O₄*C₂₉H₃₁N₇O
• 分子量: 583.647
• InChiKey: ORBITRSOBMAWBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.75
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  草酸 、 伊马替尼 以 甲醇 、 二氯甲烷 、 异丙醇 为溶剂， 反应 1.0h， 生成 imatinib oxalate
  参考文献：
  名称：

  [EN] NOVEL SALTS OF IMATINIB
  [FR] NOUVEAUX SELS D'IMATINIB

  摘要：

  本发明揭示了公式（II）的伊马替尼的药用可接受盐，其中S代表从草酸、对甲苯磺酸、萘磺酸、苯磺酸、硝酸、磷酸、乙酸、马来酸、富马酸、赖氨酸、赖氨酸HCl、精氨酸等氨基酸中选择的酸，与伊马替尼形成盐。

  公开号：

  WO2012090221A1

文献信息

• Acid addition salts of imatinib and formulations comprising the same
  申请人：Eczacibasi-Zentiva Kimyasal Ürünler Sanayi ve Ticaret A.S.

  公开号：EP2062885A1

  公开（公告）日：2009-05-27

  Acid addition salts of 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide selected from the group consisting of an orotate salt, an oxalate salt, a nicotinate salt, a camphor sulfonate salt, a paratoluene sulfonate salt, a laurate salt, an aspartate salt, a caprate salt, an oleate salt and a phenyl acetate salt is disclosed. The invention further provides a method for producing said acid addition salts and formulations, preferably solid formulations comprising at least one of said salts within the composition.

  4-[(4-甲基-1-哌嗪基)甲基]-N-[4-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]苯基]-苯甲酰胺的酸加成盐，选自由乳清酸盐组成的组、本发明公开了草酸盐、烟酸盐、樟脑磺酸盐、对甲苯磺酸盐、月桂酸盐、天门冬氨酸盐、癸酸盐、油酸盐和乙酸苯酯盐。本发明进一步提供了生产所述酸加成盐和制剂的方法，优选的是在组合物中包含至少一种所述盐的固体制剂。
• [EN] NOVEL ACID ADDITION SALTS OF IMATINIB AND FORMULATIONS COMPRISING THE SAME<br/>[FR] NOUVEAUX SELS D'ADDITION ACIDES D'IMATINIB ET FORMULATIONS LES CONTENANT
  申请人：ECZACIBASI ZENTIVA KIMYASAL UE

  公开号：WO2009065910A2

  公开（公告）日：2009-05-28

  Acid addition salts of 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide selected from the group consisting of an orotate salt, an oxalate salt, a nicotinate salt, a camphor sulfonate salt, a para-toluene sulfonate salt, a laurate salt, an aspartate salt, a caprate salt, an oleate salt and a phenyl acetate salt is disclosed. The invention further provides a method for producing said acid addition salts and formulations, preferably solid formulations comprising at least one of said salts within the composition.
• [EN] NOVEL SALTS OF IMATINIB<br/>[FR] NOUVEAUX SELS D'IMATINIB
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2012090221A1

  公开（公告）日：2012-07-05

  The present inventiin discloses pharmaceutically acceptable salts of imatinib of Formula (II) wherein in S represent the acid selected from the group consisting of oxalic acid, ptoluene sulfonic acid, naphthalene sulfonic acid, benzene sulfonic acid, nitric acid, phosphoric acid, acetic acid, maleic acid, fumaric acid, amino acids like lysine, lysine HC1, arginine; which forms a salt with imatinib.

  本发明揭示了公式（II）的伊马替尼的药用可接受盐，其中S代表从草酸、对甲苯磺酸、萘磺酸、苯磺酸、硝酸、磷酸、乙酸、马来酸、富马酸、赖氨酸、赖氨酸HCl、精氨酸等氨基酸中选择的酸，与伊马替尼形成盐。