(2R)-4-biphenyl-4-yl-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide | 1289626-94-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R)-4-biphenyl-4-yl-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide
• 英文别名: (2R)-4-Biphenyl-4-yl-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide；(2R)-2-methyl-2-methylsulfonyl-N-(oxan-2-yloxy)-4-(4-phenylphenyl)butanamide
• CAS: 1289626-94-3
• 化学式: C₂₃H₂₉NO₅S
• 分子量: 431.553
• InChiKey: SXIKBFHBWJAWQC-JFGZAKSSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  90.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2R)-4-biphenyl-4-yl-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.25h， 以55%的产率得到(+)-(2R)-4-biphenyl-4-yl-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide
  参考文献：
  名称：

  [EN] C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS
  [FR] DÉRIVÉS D'ACIDE HYDROXAMIQUE À LIAISON C UTILES COMME AGENTS ANTIBACTÉRIENS

  摘要：

  公开号：

  WO2011045703A3
• 作为产物：
  描述：

  溴苯 、 (2R)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanamide 在 tris-(dibenzylideneacetone)dipalladium(0) potassium carbonate 作用下， 以 甲醇 、 乙二醇二甲醚 为溶剂， 以8%的产率得到(2R)-4-biphenyl-4-yl-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide
  参考文献：
  名称：

  [EN] C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS
  [FR] DÉRIVÉS D'ACIDE HYDROXAMIQUE À LIAISON C UTILES COMME AGENTS ANTIBACTÉRIENS

  摘要：

  公开号：

  WO2011045703A3

文献信息

• C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents
  申请人：Brown Matthew Frank

  公开号：US20120202777A1

  公开（公告）日：2012-08-09

  The present invention is directed to a new class of hydroxamic acid derivatives of Formula I, wherein the variables G, T, D, L, A, X, R 1 and R 2 are as described hereinabove, and their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.

  本发明涉及一种新的羟肟酸衍生物类别，其化学式为I，其中变量G、T、D、L、A、X、R1和R2如上所述，并且它们作为LpxC抑制剂的用途，更具体地用于治疗细菌感染。
• C-linked hydroxamic acid derivatives useful as antibacterial agents
  申请人：Brown Matthew Frank

  公开号：US08853258B2

  公开（公告）日：2014-10-07

  The present invention is directed to a new class of hydroxamic acid derivatives of Formula I, wherein the variables G, T, D, L, A, X, R1 and R2 are as described hereinabove, and their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.

  本发明涉及一种新的羟肟酸衍生物类别，其化学式为I，其中变量G、T、D、L、A、X、R1和R2如上所述，并且它们作为LpxC抑制剂的用途，更具体地说，它们用于治疗细菌感染。
• AGENTS FOR IMPROVING THE TASTE AND FLAVOR OF CHOCOLATE
  申请人：TANIZAWA Junko

  公开号：US20120201944A1

  公开（公告）日：2012-08-09

  An agent for improving the eating quality of chocolate products is disclosed; it comprises as an active ingredient a yeast extract comprising (a) free glutamic acid in an amount of at least 10 wt % (preferably at least 15%) as calculated for sodium glutamate, (b) disodium 5′-inosinate and disodium 5′-guanylate in a total amount of at least 1 wt % (preferably at least 1.5 wt %), and (c) 2-furanmethanol and/or 5-methyl-2-furanmethanol.
• MULTILAYER PHARMACEUTICAL OR NUTRACEUTICAL SOLID DOSAGE FORMS COMPRISING PYRIMIDINE AND/OR PURINE DERIVATIVES AND B VITAMINS, PREPARATION AND USES THEREOF
  申请人：FERRER INTERNACIONAL, S.A.

  公开号：US20220160744A1

  公开（公告）日：2022-05-26

  The present invention relates to a multilayer pharmaceutical or nutraceutical solid dosage form comprising at least one pyrimidine derivative, purine derivative or any salt or solvate thereof and least one B-group vitamin. It also provides three methods for producing said multilayer pharmaceutical or nutraceutical solid dosage forms. Furthermore, the present invention is also related to therapeutic uses of said multilayer pharmaceutical or nutraceutical solid dosage forms, particularly for the treatment and/or prevention of peripheral neuropathy.
• US8853258B2
  申请人：——

  公开号：US8853258B2

  公开（公告）日：2014-10-07