Methyl-cyclooct-2-en-1-carboxylat | 16166-97-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl-cyclooct-2-en-1-carboxylat
• 英文别名: methyl (2Z)-cyclooct-2-ene-1-carboxylate
• CAS: 16166-97-5
• 化学式: C₁₀H₁₆O₂
• 分子量: 168.236
• InChiKey: KPXFSOAUFBDJJS-ALCCZGGFSA-N

物化性质

• 沸点：
  221.2±29.0 °C(Predicted)
• 密度：
  0.973±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Methyl-cyclooct-2-en-1-carboxylat 在 苯甲酸甲酯 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 24.0h， 以42%的产率得到methyl (2E)-cyclooct-2-ene-1-carboxylate
  参考文献：
  名称：

  Bond-Breaking Bio-orthogonal Chemistry Efficiently Uncages Fluorescent and Therapeutic Compounds under Physiological Conditions

  摘要：

  Bond-breaking bio-orthogonal chemistry, consisting of a "click" reaction between trans-cyclooctene and tetrazine, followed by an intramolecular cyclization-driven uncaging step is described. The two-step process allows activation of caged compounds in biological media at neutral pH. The feasibility of this chemistry has been illustrated using NMR, while kinetics and pH-dependence were studied by fluorescence spectroscopy using caged coumarin. The practicality of the strategy is illustrated by activation of an anticancer drug, etoposide.

  DOI：

  10.1021/acs.orglett.0c02129
• 作为产物：
  描述：

  Cyclooct-2-en-1-ol Methoxyacetate Ester 生成 Methyl-cyclooct-2-en-1-carboxylat
  参考文献：
  名称：

  Preparation of .beta.,.gamma.-unsaturated methyl esters from allylic alcohols

  摘要：

  DOI：

  10.1021/jo01309a013

文献信息

• BIO-ORTHOGONAL DRUG ACTIVATION
  申请人：KONINKLIJKE PHILIPS N.V.

  公开号：US20160106859A1

  公开（公告）日：2016-04-21

  The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives.

  该发明涉及一种用于治疗学的原药激活方法，其中使用了表现出彼此生物正交反应性的非生物活性化学基团。该发明还涉及一种包含至少一种原药和至少一种激活剂的试剂盒，其中原药包含药物和第一个生物正交反应基团（触发器），而激活剂包含第二个生物正交反应基团。该发明还涉及在上述方法和试剂盒中使用的靶向治疗剂。该发明特别适用于抗体药物偶联物和双特异性及三特异性抗体衍生物。
• Synthesis and utility of ethylene (meth)acrylate copolymers prepared by a tandem ring-opening polymerization hydrogenation strategy
  作者：Sebla Onbulak、Yanzhao Wang、Jacob P. Brutman、Marc A. Hillmyer

  DOI：10.1002/pola.28686

  日期：2017.9.15

  functional cyclooctene were prepared and (co)polymerized using ring‐opening metathesis polymerization. The resulting polymers were hydrogenated to yield the corresponding functional polyolefins that were structurally equivalent to copolymers of ethylene and either methyl methacrylate, t‐butyl acrylate, or acrylic acid after deprotection. The copolymers that incorporate methyl methacrylate into the

  制备了一种新的和一种已建立的功能性环辛烯，并使用开环易位聚合进行了（共）聚合。将所得的聚合物进行氢化，得到相应的官能聚烯烃，在结构上相当于脱保护后的乙烯与甲基丙烯酸甲酯，丙烯酸叔丁酯或丙烯酸的共聚物。将甲基丙烯酸甲酯掺入主链的共聚物用作聚（甲基丙烯酸甲酯）/聚乙烯共混物的相容剂。将丙烯酸叔丁酯掺入骨架的共聚物产生了可以热交联的弹性体。©2017 Wiley Periodicals，Inc. J. Polym。科学，A部分：Polym。化学 2017年，55，3117-3126
• Linear functional copolymers of ethylene with precise and minimum run length distributions and method of making thereof
  申请人：Baugh S. Lisa

  公开号：US20050137369A1

  公开（公告）日：2005-06-23

  The present invention is related to a linear functional polymer having repeating units A, B and D. Unit A represents —CH 2 —, unit B represents and unit D represents where R 1 represents a polar functional group. There are at least four A units separating each B unit, each D unit, and each B and D unit. The value y represents the total number of B units and is an integer greater than or equal to 1. The total number of D units is represented by h and is an integer greater than or equal to 0. And x represents the total number of A units and is an integer sufficient that the molar fraction of the B and D units in the linear functional polymer is represented by a value j defined by the equation: j = y + h x + y + h ≤ 0.032 . The present invention is also directed to a method for preparing such linear functional polymers by copolymerizing a first polar substituted monomer and a second non-polar unsubstituted monomer.

  本发明涉及一种具有重复单元A、B和D的线性功能聚合物。单元A代表—CH2—，单元B代表，单元D代表其中R1代表极性官能团。每个B单元、每个D单元和每个B和D单元之间至少有四个A单元。值y表示B单元的总数，是大于或等于1的整数。D单元的总数由h表示，是大于或等于0的整数。x表示A单元的总数，是一个足够使线性功能聚合物中B和D单元的摩尔分数由方程式j定义的整数，j=y+hx+y+h≤0.032。本发明还涉及一种制备这种线性功能聚合物的方法，通过共聚第一极性取代单体和第二非极性未取代单体。
• Linear functional copolymers of ethylene with precise and minimum run length distributions and methods of making thereof
  申请人：Baugh Lisa S.

  公开号：US20080312393A1

  公开（公告）日：2008-12-18

  The present invention is related to a linear functional polymer having repeating units A, B and D. Unit A represents —CH 2 —, unit B represents and unit D represents where R 1 represents a polar functional group. There are at least four A units separating each B unit, each D unit, and each B and D unit. The value y represents the total number of B units and is an integer greater than or equal to 1. The total number of D units is represented by h and is an integer greater than or equal to 0. And x represents the total number of A units and is an integer sufficient that the molar fraction of the B and D units in the linear functional polymer is represented by a value j defined by the equation: j = y + h x + y + h ≤ 0.032 . The present invention is also directed to a method for preparing such linear functional polymers by copolymerizing a first polar substituted monomer and a second non-polar unsubstituted monomer.

  本发明涉及一种具有重复单元A、B和D的线性功能聚合物。单元A表示—CH2—，单元B表示，单元D表示其中R1表示极性官能团。每个B单元、每个D单元和每个B和D单元之间至少有四个A单元。值y表示B单元的总数，是大于或等于1的整数。D单元的总数由h表示，是大于或等于0的整数。x表示A单元的总数，是一个足够的整数，使得线性功能聚合物中B和D单元的摩尔分数由等式j定义，j=y+hx+y+h≤0.032。本发明还涉及一种通过共聚第一极性取代单体和第二非极性未取代单体制备这种线性功能聚合物的方法。
• POLYMER, AND SOLAR CELL SEALANT USING SAME
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2781531A1

  公开（公告）日：2014-09-24

  Provided is a polymer from which an encapsulant excellent in weather resistance and processability can be obtained when being used for an encapsulant for a solar cell. The polymer that has a main chain comprising repeating units represented by formula (1) and repeating units represented by formula (2) and satisfies requirements (a1), (a2), and (a3), (a1) : the ratio of the number of the repeating units represented by formula (2) to the total number of the carbon atoms that constitute the main chain of the polymer is from 3.8% to 7.5%; (a2) : the ratio X represented by formula (3) is from 82% to 100%; X=100×A/B (a3) : the polymer has a melting point of 42°C to 90°C as measured with a differential scanning calorimeter.

  本发明提供了一种聚合物，用它制成的封装剂在用于太阳能电池的封装剂时可获得优异的耐候性和加工性。该聚合物的主链由式（1）表示的重复单元和式（2）表示的重复单元组成，并满足（a1）、（a2）和（a3）的要求、 (a1) 式(2)代表的重复单元数与构成聚合物主链的碳原子总数之比为 3.8%至 7.5%； (a2) 式(3)代表的比率 X 为 82%至 100%；X=100×A/B (a3) : 用差示扫描量热计测量，聚合物的熔点为 42°C 至 90°C。