2-methoxy-4-(7-methoxy-3-methyl-5-propyl-2,3-dihydro-benzofuran-2-yl)-phenol | 4731-87-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 2-methoxy-4-(7-methoxy-3-methyl-5-propyl-2,3-dihydro-benzofuran-2-yl)-phenol
• 英文别名: dihydrodehydrodiisoeugenol；(+/-)-2-methoxy-4-(7-methoxy-3t-methyl-5-propyl-2,3-dihydro-benzofuran-2r-yl)-phenol；Hydroxymethoxyphenyl propylmethylmethoxybenzofuran；2-methoxy-4-[(2S,3S)-7-methoxy-3-methyl-5-propyl-2,3-dihydro-1-benzofuran-2-yl]phenol
• CAS: 4731-87-7；51267-48-2
• 化学式: C₂₀H₂₄O₄
• 分子量: 328.408
• InChiKey: KXTZWNLTEJAHKW-BUXKBTBVSA-N

物化性质

• 熔点：
  94 °C
• 沸点：
  438.8±45.0 °C(Predicted)
• 密度：
  1.134±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methoxy-4-(7-methoxy-3-methyl-5-propyl-2,3-dihydro-benzofuran-2-yl)-phenol 在 sodium hydroxide 作用下， 生成 2-[(Z)-2-(4-Hydroxy-3-methoxy-phenyl)-1-methyl-vinyl]-6-methoxy-4-propyl-phenol
  参考文献：
  名称：

  Wallis,A.F.A., Australian Journal of Chemistry, 1972, vol. 25, p. 1529 - 1535

  摘要：

  DOI：
• 作为产物：
  描述：

  dehydrodiisoeugenol 在 palladium on activated charcoal 、 乙醇 作用下， 生成 2-methoxy-4-(7-methoxy-3-methyl-5-propyl-2,3-dihydro-benzofuran-2-yl)-phenol
  参考文献：
  名称：

  Aulin-Erdtman, Svensk Kemisk Tidskrift, 1942, vol. 54, p. 168

  摘要：

  DOI：

文献信息

• USE OF DIHYDRODEHYDRODIISOEUGENOL AND PREPARATIONS COMPRISING DIHYDRODEHYDRODIISOEUGENOL
  申请人：Meyer Imke

  公开号：US20130101650A1

  公开（公告）日：2013-04-25

  This invention relates to cosmetic and pharmaceutical preparations comprising (i) a diastereomer or a mixture of two or more diastereomers of the compound of formula (I) or (ii) a salt of a diastereomer or of a mixture of two or more diastereomers of the compound of formula (I) or (iii) a mixture of two or more salts of a diastereomer or of a mixture of two or more diastereomers of the compound of formula (I), a diastereomer, salt or a mixture as defined above as a drug for topical application and/or for the treatment of lipoatrophy; the non-therapeutic use of a diastereomer, salt or a mixture as defined above for the prevention, treatment or reduction of skin aging, especially skin wrinkles; the use of a diastereomer, salt or a mixture as defined above for the production of an orally administered non-pharmaceutical preparation.

  本发明涉及包含(i)化合物的对映异构体或两个或两个以上对映异构体的混合物或(ii)化合物的对映异构体或两个或两个以上对映异构体的混合物的盐或(iii)化合物的对映异构体或两个或两个以上对映异构体的混合物的两个或两个以上盐的混合物的化妆品和药用制剂，上述对映异构体、盐或混合物被定义为用于局部应用的药物和/或治疗脂肪萎缩；上述对映异构体、盐或混合物的非治疗用途被定义为用于预防、治疗或减少皮肤老化，特别是皱纹；上述对映异构体、盐或混合物被定义为用于制造口服非药用制剂。
• Gellerstedt,G.; Gierer,J., Acta Chemica Scandinavica (1947), 1968, vol. 22, # 6, p. 2029 - 2031
  作者：Gellerstedt,G.、Gierer,J.

  DOI：——

  日期：——
• Leopold, Acta Chemica Scandinavica (1947), 1950, vol. 4, p. 1523,1533
  作者：Leopold

  DOI：——

  日期：——
• [EN] USE OF DIHYDRODEHYDRODIISOEUGENOL AND PREPARATIONS COMPRISING DIHYDRODEHYDRODIISOEUGENOL<br/>[FR] UTILISATION DE DIHYDRODÉHYDRODIISOEUGENOL ET PRÉPARATIONS COMPRENANT DU DIHYDRODÉHYDRODIISOEUGENOL
  申请人：SYMRISE GMBH & CO KG

  公开号：WO2010070152A2

  公开（公告）日：2010-06-24

  This invention relates to cosmetic and pharmaceutical preparations comprising (i) a diastereomer or a mixture of two or more diastereomers of the compound of Formula (I), or (ii) a salt of a diastereomer or of a mixture of two or more diastereomers of the compound of formula (I) or (iii) a mixture of two or more salts of a diastereomer or of a mixture of two or more diastereomers of the compound of formula (I), a diastereomer, salt or a mixture as defined above as a drug for topical application and/or for the treatment of lipoatrophy; the non-therapeutic use of a diastereomer, salt or a mixture as defined above for the prevention, treatment or reduction of skin aging, especially skin wrinkles; the use of a diastereomer, salt or a mixture as defined above for the production of an orally administered non-pharmaceutical preparation.
• Wallis,A.F.A., Australian Journal of Chemistry, 1972, vol. 25, p. 1529 - 1535
  作者：Wallis,A.F.A.

  DOI：——

  日期：——