tert-butyl 3-(bromomethyl)-5-[(methylsulfonyl)oxy]benzoate | 887969-79-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl 3-(bromomethyl)-5-[(methylsulfonyl)oxy]benzoate
• 英文别名: Tert-butyl 3-(bromomethyl)-5-[(methylsulfonyl)oxy]benzoate；tert-butyl 3-(bromomethyl)-5-methylsulfonyloxybenzoate
• CAS: 887969-79-1
• 化学式: C₁₃H₁₇BrO₅S
• 分子量: 365.245
• InChiKey: NFZUNLZEHLHNBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  78
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  tert-butyl 3-(hydroxymethyl)-5-[(methylsulfonyl)oxy]benzoate 在 四溴化碳 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以61%的产率得到tert-butyl 3-(bromomethyl)-5-[(methylsulfonyl)oxy]benzoate
  参考文献：
  名称：

  WO2006/55434

  摘要：

  公开号：

文献信息

• Macrocyclic Tertiary Amine Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease
  申请人：Nantermet Philippe G.

  公开号：US20080269302A1

  公开（公告）日：2008-10-30

  The present invention is directed to macrocyclic tertiary amine compounds represented by general formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及由通式(I)表示的大环三级胺化合物，它们是β-分泌酶酶的抑制剂，并且在治疗β-分泌酶酶参与的疾病，如阿尔茨海默病方面具有用途。本发明还涉及包含这些化合物的制药组合物，以及在治疗β-分泌酶酶参与的这些疾病方面使用这些化合物和组合物。
• Macrocyclic tertiary amine beta-secretase inhibitors for the treatment of alzheimer's disease
  申请人：Merck Sharp & Dohme Corp.

  公开号：US07678783B2

  公开（公告）日：2010-03-16

  The present invention is directed to macrocyclic tertiary amine compounds represented by general formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及由一般式（I）表示的大环三级胺化合物，它们是β-分泌酶酶的抑制剂，可用于治疗β-分泌酶酶涉及的疾病，如阿尔茨海默病。本发明还涉及包含这些化合物的药物组合物，以及使用这些化合物和组合物治疗β-分泌酶酶涉及的疾病。
• MACROCYCLIC TERTIARY AMINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
  申请人：Merck & Co., Inc.

  公开号：EP1814537A2

  公开（公告）日：2007-08-08
• US7678783B2
  申请人：——

  公开号：US7678783B2

  公开（公告）日：2010-03-16
• [EN] MACROCYCLIC TERTIARY AMINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] INHIBITEURS DE LA BETA-SECRETASE FORMES D'AMINES TERTIAIRES MACROCYCLIQUES POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：MERCK & CO INC

  公开号：WO2006055434A2

  公开（公告）日：2006-05-26

  [EN] The present invention is directed to macrocyclic tertiary amine compounds represented by general formula (I), which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
  [FR] L'invention concerne des composés formés d'amines tertiaires macrocycliques de formule générale (I), qui sont des inhibiteurs de l'enzyme bêta-sécrétase et qui sont utiles dans le traitement de maladies dans lesquelles l'enzyme bêta-sécrétase est impliquée, notamment la maladie d'Alzheimer. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés et l'utilisation de ceux-ci et desdites compositions dans le traitement des maladies dans lesquelles l'enzyme bêta-sécrétase est impliquée.