N-{4-chloro-2-[1-(4-chlorophenoxyimino)-2-methylpropyl]phenyl}trifluoromethanesulfonamide | 880473-07-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-{4-chloro-2-[1-(4-chlorophenoxyimino)-2-methylpropyl]phenyl}trifluoromethanesulfonamide
• 英文别名: N-[4-chloro-2-[N-(4-chlorophenoxy)-C-propan-2-ylcarbonimidoyl]phenyl]-1,1,1-trifluoromethanesulfonamide
• CAS: 880473-07-4
• 化学式: C₁₇H₁₅Cl₂F₃N₂O₃S
• 分子量: 455.285
• InChiKey: ZQYGTMAKYKRFHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N-(4-chloro-2-isobutyrylphenyl)trifluoromethanesulfonamide 、 p-chlorophenyloxyamine hydrochloride 在 sodium acetate 作用下， 以 乙醇 为溶剂， 生成 N-{4-chloro-2-[1-(4-chlorophenoxyimino)-2-methylpropyl]phenyl}trifluoromethanesulfonamide
  参考文献：
  名称：

  Parasiticidal 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilides

  摘要：

  A series of novel 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilide derivatives have shown significant in vitro parasiticidal activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. A number of these compounds also displayed significant in vitro endoparasite activity against the nematode Haemonchus contortus. Crown copyright (C) 2007 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.090

文献信息

• CONTROL OF PARASITES IN ANIMALS BY THE USE OF NOVEL TRIFLUOROMETHANESULFONANILIDE OXIME ETHER DERIVATIVES
  申请人：Meyer Adam Gerhard

  公开号：US20080262048A1

  公开（公告）日：2008-10-23

  Novel trifluoromethanesulfonanilide oxime ether compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo or ex vivo.

  提供了一种新型三氟甲磺酰苯胺肟醚化合物，可用于控制环境中的内寄生虫和/或外寄生虫，以及制备该化合物的方法和使用该创新化合物治疗体内或体外寄生虫感染的方法。
• Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
  申请人：Schering-Plough Animal Health Corporation

  公开号：US07312248B2

  公开（公告）日：2007-12-25

  Novel trifluoromethanesulfonanilide oxime ether compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo or ex vivo.

  本发明提供了一种新型三氟甲磺酰苯胺肟醚化合物，用于控制环境中的内寄生虫和/或外寄生虫，同时提供了制备该化合物的方法，以及使用该创新化合物治疗体内或体外寄生虫感染的方法。
• Parasiticidal 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilides
  作者：Abdelselam Ali、Timothy M. Altamore、Marianne Bliese、Petr Fisara、Andris J. Liepa、Adam G. Meyer、Oahn Nguyen、Roger M. Sargent、David G. Sawutz、David A. Winkler、Kevin N. Winzenberg、Angela Ziebell

  DOI：10.1016/j.bmcl.2007.10.090

  日期：2008.1

  A series of novel 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilide derivatives have shown significant in vitro parasiticidal activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. A number of these compounds also displayed significant in vitro endoparasite activity against the nematode Haemonchus contortus. Crown copyright (C) 2007 Published by Elsevier Ltd. All rights reserved.