2-chlorophenyl carbamate | 97611-33-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chlorophenyl carbamate
• 英文别名: carbamic acid-(2-chloro-phenyl ester)；Carbamidsaeure-(2-chlor-phenylester)；(2-Chlor-phenyl)-carbamat；(2-chlorophenyl) carbamate
• CAS: 97611-33-1
• 化学式: C₇H₆ClNO₂
• 分子量: 171.583
• InChiKey: XNRBLQMJVXSCAJ-UHFFFAOYSA-N

物化性质

• 沸点：
  317.0±34.0 °C(Predicted)
• 密度：
  1.359±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  氯甲酸邻氯苯酚酯 在 氨 作用下， 生成 2-chlorophenyl carbamate
  参考文献：
  名称：

  NEW CHLOROCARBONATES DERIVED FROM AROMATIC AND DIHYDROXY ALCOHOLS

  摘要：

  DOI：

  10.1021/ja01687a028

文献信息

• 4-Dodecylbenzenesulfonic acid (DBSA) promoted solvent-free diversity-oriented synthesis of primary carbamates, S-thiocarbamates and ureas
  作者：Ali Reza Sardarian、Iman Dindarloo Inaloo

  DOI：10.1039/c5ra14528g

  日期：——

  A simple and efficient solvent-free preparation of primary carbamates,S-thiocarbamates and ureas from alcohols, phenols, thiols and amines in the presence of 4-dodecylbenzenesulfonic acid, as a cheap and green Brønsted acid, has been described.

  一种简单高效的无溶剂制备方法，可将醇、酚、硫醇和胺转化为一次氨基甲酸酯、S-硫代氨基甲酸酯和脲，该方法使用4-十二烷基苯磺酸作为廉价环保的Brønsted酸。
• Reagents for rapid peptide synthesis
  申请人：RESEARCH CORPORATION TECHNOLOGIES, INC.

  公开号：EP0401817A2

  公开（公告）日：1990-12-12

  This invention relates to compounds of the formula: wherein R is an electron withdrawing group; R₁ is H or COZ; X₁ and X₂ are independently H, lower alkyl, aryl, aryl lower-alkyl or polystyrene or R and X₁ taken together with the carbon atoms to which they are attached form a ring containing from 4 to 15 ring carbon atoms and may contain up to 2 heteroatoms, wherein the heteroatoms are O, S, or N; and Z is an amino acid residue, a peptide residue or a leaving group. The compounds of the present invention are adaptable as blocking or protecting groups for an amine composition useful in peptide synthesis. The present invention is also directed to a method of protecting an amino group of an organic molecule during a reaction which modifies a portion of the molecule other than the protected amino group.

  本发明涉及式中的化合物： 其中 R 是取电子基团； R₁ 是 H 或 COZ； X₁ 和 X₂ 独立地为 H、低级烷基、芳基、芳基低级烷基或聚苯乙烯，或 R 和 X₁ 与它们所连接的碳原子一起形成一个环，该环含 4 至 15 个环状碳原子，最多可包含 2 个杂原子，其中杂原子为 O、S 或 N；以及 Z 是氨基酸残基、肽残基或离去基团。本发明的化合物可用作肽合成中胺类组合物的封端或保护基团。本发明还涉及一种在反应过程中保护有机分子氨基的方法，该反应改变了分子中除受保护氨基以外的部分。
• Pyrrolotriazole derivative
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0518238A1

  公开（公告）日：1992-12-16

  A novel pyrrolotriazole derivative is disclosed, represented by any one of formulae (I), (II), or (III): wherein:    R¹, R², R³ and R⁴ each independently represents a hydrogen atom or a nonmetallic atomic group;    R⁵ and R⁶ each independently represents a hydrogen atom, alkyl group, an aryl group, or a heterocyclic group;    R⁷ represents an electrophilic group having a Hammett's substituent constant σp of 0.15 or more;    R⁸ and R⁹ each independently represents a hydrogen atom or a nonmetallic atomic group;    the sum of Hammett's substituent constant σp of R⁷ and R⁸ is 0.65 or more;    R¹ and R², and/or R² and R⁵, and/or R⁵ and R⁶, and/or R⁶ and R³, and/or R³ and R⁴ may be connected to each other to form a cyclic structure;    R⁷ and R⁸ may be connected to each other to form a cyclic structure; and    Z represents a hydrogen atom, a halogen atom, an arylthio group, a heterocyclic thio group, an arylsulfinyl group, or a nitroso group.

  本发明公开了一种新型吡咯三唑衍生物，由式（I）、（II）或（III）中的任意一个表示： 其中 R¹、R²、R³ 和 R⁴ 各自独立地代表氢原子或非金属原子团； R⁵ 和 R⁶ 各自独立地代表氢原子、烷基、芳基或杂环基团； R⁷ 代表亲电基团，其哈米特取代基常数 σp 为 0.15 或更大； R⁸ 和 R𠞙 各自独立地代表氢原子或非金属原子团； R⁷ 和 R⁸ 的哈米特取代常数 σp 之和为 0.65 或以上； R¹ 和 R²、和/或 R² 和 R⁵、和/或 R⁵ 和 R⁶、和/或 R⁶ 和 R³、和/或 R³ 和 R⁴ 可相互连接形成环状结构； R⁷ 和 R⁸ 可相互连接形成环状结构；以及 Z 代表氢原子、卤素原子、芳硫基、杂环硫基、芳基亚磺酰基或亚硝基。
• Imidazole azo dyes and thermal transfer dye donating materials containing them
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0545420A2

  公开（公告）日：1993-06-09

  Disclosed is an imidazole azo dye of formula (I), which is useful for image formation and as a filter dye, which has a sharp absorption wave and which is fast to light, heat, air, moisture and chemicals. Also disclosed is a thermal transfer dye-donating material containing imidazole azo dye(s) of formula (I) preferably along with aminopyrazole azo dye(s) of formula (II). The material gives a high-density image with good color reproduction, and the image formed has improved storage stability. In (I), B and C independently represent a hydrogen atom or a substituent capable of being substituted in the imidazole ring; A represents an aryl or heterocyclic group; provided that when B is a hydrogen atom, C is not a hydrogen atom nor an alkyl group having from 1 to 3 carbon atoms; provided that when C is a hydrogen atom, B is not a substituted nor unsubstituted alkyl group; provided that C is not a mercapto group or an alkylthio group; and provided that B is not a carboxyl group. In (II), D represents a hydrogen atom, or an alkyl, aryl, or heterocyclic group, E represents a substituent capable of being substituted in the pyrazole ring, F represents an aryl or heteroaromatic group, and G and I independently represent a hydrogen atom, or an alkyl, aryl, or heterocyclic group.

  本发明公开了一种式(I)的咪唑偶氮染料，该染料可用于形成图像和用作过滤染料，它具有尖锐的吸收波，并且对光、热、空气、湿气和化学品具有快速吸收性。本发明还公开了一种热转印染料捐赠材料，该材料最好含有式（I）的咪唑偶氮染料和式（II）的氨基吡唑偶氮染料。该材料可产生色彩再现性良好的高密度图像，所形成的图像具有更好的储存稳定性。 在（I）中，B 和 C 独立地代表氢原子或咪唑环中能够被取代的取代基；A 代表芳基或杂环基；条件是当 B 是氢原子时，C 不是氢原子或具有 1 至 3 个碳原子的烷基；条件是当 C 是氢原子时，B 不是取代或未取代的烷基；条件是 C 不是巯基或烷硫基；以及条件是 B 不是羧基。 在(II)中，D 代表氢原子或烷基、芳基或杂环基，E 代表吡唑环中可被取代的取代基，F 代表芳基或杂芳基，G 和 I 独立地代表氢原子或烷基、芳基或杂环基。
• Carboline derivatives useful in the inhibition of angiogenesis
  申请人：PTC Therapeutics, Inc.

  公开号：EP2431369A2

  公开（公告）日：2012-03-21

  In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.

  根据本发明，已鉴定出转录后抑制血管内皮生长因子表达的化合物，并提供了使用这些化合物的方法。在本发明的一个方面，提供了可用于抑制血管内皮生长因子产生、抑制血管生成和/或治疗癌症、糖尿病视网膜病变或渗出性黄斑变性的化合物。在本发明的另一方面，提供了使用本发明化合物抑制 VEGF 生成、抑制血管生成和/或治疗癌症、糖尿病视网膜病变或渗出性黄斑变性的方法。