N-(2-methoxypyridin-5-yl)benzenesulfonamide | 719269-29-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-methoxypyridin-5-yl)benzenesulfonamide
• 英文别名: N-(6-methoxy-3-pyridinyl)benzenesulfonamide；N-(6-methoxypyridin-3-yl)benzenesulfonamide
• CAS: 719269-29-1
• 化学式: C₁₂H₁₂N₂O₃S
• mdl: MFCD03102351
• 分子量: 264.305
• InChiKey: NUIHZRUZEGKXPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.083
• 拓扑面积：
  76.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  苯磺酰胺 、 5-溴-2-甲氧基吡啶 在 copper(l) iodide 、 potassium carbonate 、 N,N'-二甲基乙二胺 作用下， 以 乙腈 为溶剂， 反应 8.0h， 以91%的产率得到N-(2-methoxypyridin-5-yl)benzenesulfonamide
  参考文献：
  名称：

  Copper-catalyzed N-arylation of sulfonamides with aryl bromides under mild conditions

  摘要：

  This Letter describes a copper catalyzed sulfonamide coupling reaction with aryl bromides to form N-aryl sulfonamides under mild conditions, including the first examples of Cu-catalyzed sulfonamide coupling at room temperature. The reaction protocol tolerates a broad range of substrates including a variety of primary and secondary sulfonamides and challenging heteroaryl bromides such as 2-bromothiazole. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.113

文献信息

• Copper-catalyzed N-arylation of sulfonamides with aryl bromides under mild conditions
  作者：Xiang Wang、Anil Guram、Michael Ronk、Jacqueline E. Milne、Jason S. Tedrow、Margaret M. Faul

  DOI：10.1016/j.tetlet.2011.10.113

  日期：2012.1

  This Letter describes a copper catalyzed sulfonamide coupling reaction with aryl bromides to form N-aryl sulfonamides under mild conditions, including the first examples of Cu-catalyzed sulfonamide coupling at room temperature. The reaction protocol tolerates a broad range of substrates including a variety of primary and secondary sulfonamides and challenging heteroaryl bromides such as 2-bromothiazole. (C) 2011 Elsevier Ltd. All rights reserved.