Benzoesaeure--anhydrid | 96878-42-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzoesaeure--anhydrid
• 英文别名: benzoic acid-(2-nitro-benzoic acid )-anhydride；Benzoesaeure-(2-nitro-benzoesaeure)-anhydrid；Benzoyl 2-nitrobenzoate；benzoyl 2-nitrobenzoate
• CAS: 96878-42-1
• 化学式: C₁₄H₉NO₅
• 分子量: 271.229
• InChiKey: IVJXYUFXXFXLOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  三氯化铝 、 Benzoesaeure--anhydrid 、 苯 生成 二苯甲酮 、 邻硝基苯甲酸
  参考文献：
  名称：

  Sixteen years of old-field succession and reestablishment of a bottomland hardwood forest in the Lower Mississippi Alluvial Valley

  摘要：

  In the Lower Mississippi Alluvial Valley (LMAV), losses of bottomland hardwood forests have been severe, with less than 30% of the original 10 million ha remaining. Reforestation of abandoned farmland is occurring, but there has been little research on natural reestablishment of these forests. We examined understory succession and tree establishment patterns in a 3.2-ha field in northeast Louisiana, USA, abandoned in 1984. Relative elevation, strongly correlated with flooding depth and frequency, varied by approximately 1m. Ground-layer composition was monitored from 1985 to 1999 in twenty 1-m(2) quadrats stratified along the elevation gradient. In 2000, shrubs and tree saplings were mapped and their relative elevations determined. Ordination of the ground-layer data revealed that the major trends in species composition were related to time-since-abandonment and elevation. Annual species gradually declined, woody perennials became more abundant, and a shrub and young tree layer emerged from beneath the ground layer, but species composition in low and high elevation plots did not converge. Obligate species were more common at lower elevations, while facultative species were more common at upper elevations. By 16 years after abandonment, a total of 16 tree and shrub species had established in the field; eleven of these had potential local seed sources on levees adjacent to the study site. Abundance of dominant species was significantly related to elevation in most cases. In addition, distance to seed source influenced density and spatial distribution of Celtis laevigata and Fraxinus pennsylvanica. Our study suggests that rate and pattern of secondary succession in LMAV bottomlands are strongly influenced by elevation, dispersal mode of species, and the composition and proximity of forest remnants. Successful restoration of bottomland forests will require an improved understanding of these factors.

  DOI：

  10.1672/0277-5212(2002)022[0001:syoofs]2.0.co;2
• 作为产物：
  描述：

  邻硝基苯甲酸 、 苯甲酰氯 在 吡啶 、 乙醚 作用下， 生成 Benzoesaeure--anhydrid
  参考文献：
  名称：

  Sixteen years of old-field succession and reestablishment of a bottomland hardwood forest in the Lower Mississippi Alluvial Valley

  摘要：

  In the Lower Mississippi Alluvial Valley (LMAV), losses of bottomland hardwood forests have been severe, with less than 30% of the original 10 million ha remaining. Reforestation of abandoned farmland is occurring, but there has been little research on natural reestablishment of these forests. We examined understory succession and tree establishment patterns in a 3.2-ha field in northeast Louisiana, USA, abandoned in 1984. Relative elevation, strongly correlated with flooding depth and frequency, varied by approximately 1m. Ground-layer composition was monitored from 1985 to 1999 in twenty 1-m(2) quadrats stratified along the elevation gradient. In 2000, shrubs and tree saplings were mapped and their relative elevations determined. Ordination of the ground-layer data revealed that the major trends in species composition were related to time-since-abandonment and elevation. Annual species gradually declined, woody perennials became more abundant, and a shrub and young tree layer emerged from beneath the ground layer, but species composition in low and high elevation plots did not converge. Obligate species were more common at lower elevations, while facultative species were more common at upper elevations. By 16 years after abandonment, a total of 16 tree and shrub species had established in the field; eleven of these had potential local seed sources on levees adjacent to the study site. Abundance of dominant species was significantly related to elevation in most cases. In addition, distance to seed source influenced density and spatial distribution of Celtis laevigata and Fraxinus pennsylvanica. Our study suggests that rate and pattern of secondary succession in LMAV bottomlands are strongly influenced by elevation, dispersal mode of species, and the composition and proximity of forest remnants. Successful restoration of bottomland forests will require an improved understanding of these factors.

  DOI：

  10.1672/0277-5212(2002)022[0001:syoofs]2.0.co;2

文献信息

• [EN] ELECTRONIC TUNING OF SITE SELECTIVITY<br/>[FR] AJUSTEMENT ÉLECTRONIQUE DE SÉLECTIVITÉ DE SITE
  申请人：UNIV ILLINOIS

  公开号：WO2014059436A1

  公开（公告）日：2014-04-17

  Site-selective functionalization of Amphotericin B has been achieved by simply modifying the electronic nature of the reagents. A Hammett analysis is consistent with linking of this phenomenon to the Hammond postulate: electronic tuning to a more product- like transition state amplifies site-discriminating interactions between a reagent and its substrate. Electronic tuning of both an acylpyridinium donor and its carboxylate counterion further promoted site-divergent functionalization. A range of modifications to one of the many hydroxyl groups appended to the ion channel-forming natural product amphotericin B was achieved.

  Amphotericin B的位选择性官能化已通过简单修改试剂的电子性质实现。 Hammett分析与将这一现象与Hammond假设联系起来是一致的：对更类似产物的过渡态进行电子调谐会增强试剂与其底物之间的区位区分相互作用。对酰基吡啶阳离子供体及其羧酸盐反离子的电子调谐进一步促进了位分歧官能化。对形成离子通道的天然产物Amphotericin B之一的许多羟基基团的一系列修饰已实现。
• ARYLOYL(OXY OR AMINO)PENTAFLUOROSULFANYLBENZENE COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PRODRUGS THEREOF
  申请人：UBE INDUSTRIES, LTD.

  公开号：US20160244407A1

  公开（公告）日：2016-08-25

  An aryloyl(oxy or amino)pentafluorosulfanylbenzene compound having pharmacological action. The aryloyl(oxy or amino)pentafluorosulfanylbenzene compound is represented by general formula (A-I), a pharmaceutically acceptable salt thereof, and a prodrug thereof, wherein all of parameters represent the same meanings as defined in the specification.

  一种具有药理作用的芳基酰氧或氨基五氟磺基苯化合物。该芳基酰氧或氨基五氟磺基苯化合物由通用式(A-I)表示，其药用可接受的盐和前药，其中所有参数的含义与规范中定义的相同。
• [EN] POLYENE POLYKETIDES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS A PHARMACEUTICAL<br/>[FR] POLYKETIDES DE POLYENE, LEURS PROCESSUS DE PRODUCTION ET LEUR UTILISATION EN TANT QUE PRODUIT PHARMACEUTIQUE
  申请人：ECOPIA BIOSCIENCES INC

  公开号：WO2004065401A1

  公开（公告）日：2004-08-05

  This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensis; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to the novel strains of Streptomyces aizunensis used to produce these compounds, to the use of these compounds and their pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of fungal cell growth and cancer cell growth. The invention also relates to pharmaceutical compositions comprising these novel polyketides or a pharmaceutically acceptable salts or derivatives thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of these novel polyketides.

  这项发明涉及一类新型聚烯烃聚酮类化合物，其药用盐和衍生物，以及获得这些化合物的方法。获得这些化合物的一种方法是通过培养新的链霉菌艾尊链霉菌菌株；另一种方法涉及在转化的宿主细胞中表达生物合成途径基因。本发明还涉及用于生产这些化合物的新型链霉菌艾尊链霉菌菌株，以及将这些化合物及其药用盐和衍生物作为药物的用途，特别是将它们用作真菌细胞生长和癌细胞生长的抑制剂。该发明还涉及包含这些新型聚酮类化合物或其药用盐或衍生物的药物组合物。最后，该发明涉及新型多核苷酸序列及其编码的蛋白质，这些蛋白质参与这些新型聚酮类化合物的生物合成。
• New method for preparing tiotropium salts
  申请人：Lock Ralf

  公开号：US20060047120A1

  公开（公告）日：2006-03-02

  The invention relates to a new process for preparing tiotropium salts of general formula 1 wherein X − may have the meanings given in the claims and in the specification.

  该发明涉及一种制备一般式1中X−可能具有权利要求和说明书中所给出的意义的噻托溴铵盐的新工艺。
• Novel daunomycin and adriamycin sulfono and sulfoxo
  申请人：ABI BIOTECHNOLOGY INC.

  公开号：EP0269339A2

  公开（公告）日：1988-06-01

  This invention provides novel compounds of the formula (I): including all stereoisomers thereof, and pharmaceutically ac­ceptable salts thereof, wherein, of A and B, one is C=O and the other is SY; R is hydrogen, hydroxy or methoxy; R₁ is hydrogen or hydroxy; R₂ is hydrogen or hydroxy; X is hydrogen, hydroxy or methoxy and Y is O or O₂; provided that R and X do not both stand for methoxy. These compounds show potent growth inhibition activity against P-388 leukemia cells and are thereofore potentially useful in the treatment of cancer.

  本发明提供了式(I)的新型化合物：包括其所有立体异构体及其药学上可接受的盐类，其中，A 和 B 中，一个是 C=O，另一个是 SY；R 是氢、羟基或甲氧基；R₁ 是氢或羟基；R₂ 是氢或羟基；X 是氢、羟基或甲氧基，Y 是 O 或 O₂；条件是 R 和 X 不同时代表甲氧基。 这些化合物对 P-388 白血病细胞显示出强效的生长抑制活性，因此可能用于治疗癌症。