N-(tert-butylaminopyrrolidin-1-ylmethylene)benzenesulfonamide | 1312937-88-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(tert-butylaminopyrrolidin-1-ylmethylene)benzenesulfonamide
• 英文别名: N-(benzenesulfonyl)-N'-tert-butylpyrrolidine-1-carboximidamide
• CAS: 1312937-88-4
• 化学式: C₁₅H₂₃N₃O₂S
• 分子量: 309.433
• InChiKey: SKEMHORJSAGGBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  叔丁基异硫氰酸酯 在 potassium hydrogencarbonate 作用下， 以 乙腈 为溶剂， 反应 42.0h， 生成 N-(tert-butylaminopyrrolidin-1-ylmethylene)benzenesulfonamide
  参考文献：
  名称：

  A novel atom-efficient, one-pot synthesis of sulfonylguanidines and sulfamoylguanidines

  摘要：

  An expedient one-pot procedure for the atom-efficient production of a variety of sulfonylguanidines and sulfamoylguanidines under mild conditions is described. The route constitutes an important alternative to current methods. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.04.031

文献信息

• Facile, catalyst-free cascade synthesis of sulfonyl guanidines<i>via</i>carbodiimide coupling with amines
  作者：Debojit Hazarika、Arun Jyoti Borah、Prodeep Phukan

  DOI：10.1039/c8cc08564a

  日期：——

  An expeditious catalyst-free cascade coupling of N,N-dibromoarylsulfonamides with isonitriles and amines via carbodiimide intermediates has been developed. The protocol represents an elegant pathway for sulfonyl guanidines at room temperature within a short time with high yields and wide substrate scope. The carbodiimide intermediate could also be isolated in an appreciable yield.

  通过碳二亚胺中间体，N，N-二溴芳基磺酰胺与异腈和胺的快速无催化剂级联反应已得到开发。该方案代表了磺酰胍在室温下短时间内具有高收率和广泛底物范围的绝佳途径。碳二亚胺中间体也可以以可观的产率分离。
• A novel atom-efficient, one-pot synthesis of sulfonylguanidines and sulfamoylguanidines
  作者：Jos H.M. Lange、Stefan Verhoog、Hans J. Sanders、Arnold van Loevezijn、Chris G. Kruse

  DOI：10.1016/j.tetlet.2011.04.031

  日期：2011.6

  An expedient one-pot procedure for the atom-efficient production of a variety of sulfonylguanidines and sulfamoylguanidines under mild conditions is described. The route constitutes an important alternative to current methods. (C) 2011 Elsevier Ltd. All rights reserved.