dimethyl 3,3-dimethyl-2-oxo-4-phenylbutylphosphonate | 41640-08-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dimethyl 3,3-dimethyl-2-oxo-4-phenylbutylphosphonate
• 英文别名: Dimethyl-3,3-dimethyl-2-oxo-4-phenylbutylphosphonat；3,3-Dimethyl-2-oxo-4-phenylbutyl-phosphonsaeure-dimethylester；Dimethyl (3,3-dimethyl-2-oxo-4-phenylbutyl)phosphonate；1-dimethoxyphosphoryl-3,3-dimethyl-4-phenylbutan-2-one
• CAS: 41640-08-8
• 化学式: C₁₄H₂₁O₄P
• 分子量: 284.292
• InChiKey: IVLWJCGGTRWYSS-UHFFFAOYSA-N

物化性质

• 沸点：
  379.8±25.0 °C(Predicted)
• 密度：
  1.113±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methyl 2,2-dimethyl-3-phenylpropionate 、 甲基膦酸二甲酯 在 正丁基锂 、 ammonium chloride 作用下， 以 四氢呋喃 为溶剂， 生成 dimethyl 3,3-dimethyl-2-oxo-4-phenylbutylphosphonate
  参考文献：
  名称：

  2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 derivatives

  摘要：

  本文披露了一种展现出优异体内持续时间和活性的新型前列腺素I.sub.2（PGI.sub.2）衍生物，所述衍生物由以下一般式表示：##STR1##其中R.sub.1、X、R.sub.2和R.sub.3如本文所定义。

  公开号：

  US04775692A1

文献信息

• Phenyl-substituted prostaglandin-F type analogs
  申请人：The Upjohn Company

  公开号：US03987087A1

  公开（公告）日：1976-10-19

  This invention is a group of phenyl-substituted PGE-type, PGF-type, PGA-type and PGB-type compounds, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.

  这项发明是一组苯基取代的PGE型、PGF型、PGA型和PGB型化合物以及制造它们的过程。这些化合物可用于各种药理目的，包括抗溃疡、抑制血小板聚集、增加鼻通畅、催产以及伤口愈合。
• 2A,2B-Dihomo-11-deoxy-17(substituted phenyl)-18,19,20-trinor-PGE.sub.2
  申请人：The Upjohn Company

  公开号：US04029693A1

  公开（公告）日：1977-06-14

  This invention comprises 11-deoxy-17-phenyl-18,19,20-trinor-prostaglandin-type compounds which exhibit prostaglandin-type pharmacological activity, such as lowering blood pressure, inhibiting gastric secretion, regulating the reproductive cycle, and the like.

  这项发明涉及11-去氧-17-苯基-18,19,20-三去甲前列腺素类化合物，这些化合物表现出类前列腺素药理活性，如降低血压、抑制胃分泌、调节生殖周期等。
• 2-Decarboxy-2-amino-methyl-PGE and PGD analogs
  申请人：The Upjohn Company

  公开号：US04085139A1

  公开（公告）日：1978-04-18

  Prostaglandin analogs wherein the C-2 carboxy is replaced by an aminomethyl or (substituted amino)methyl are disclosed along with intermediates useful in their preparation and processes for their preparation. These analogs are useful for the same pharmacological purposes as the prostaglandins.

  本发明揭示了C-2羧基被氨甲基或（取代氨基）甲基所取代的前列腺素类似物，以及在其制备中有用的中间体和制备它们的过程。这些类似物与前列腺素一样，用于相同的药理目的。
• Aliphatic 2-decarboxy-2-hydroxymethyl-13,14-didehydro-PG compounds
  申请人：The Upjohn Company

  公开号：US04058564A1

  公开（公告）日：1977-11-15

  This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol and the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

  本发明涉及一些前列腺素的类似物，其中C-1羧基被一级醇所取代，而C-13和C-14之间的双键被三键所取代。本发明还提供了一些新的化学过程，用于制备上述前列腺素类似物。这些前列腺素类似物表现出类似前列腺素的活性，因此可用于与前列腺素相同的药理目的。其中包括降低血压、催产、调节生殖周期、胃抗分泌作用等。
• 2-Decarboxy-2-carboxyamino-methyl-PGF.alpha. compounds
  申请人：The Upjohn Company

  公开号：US04122282A1

  公开（公告）日：1978-10-24

  Prostaglandin analogs wherein the C-2 carboxy is replaced by an aminomethyl or (substituted amino)methyl are disclosed along with intermediates useful in their preparation and processes for their preparation. These analogs are useful for the same pharmacological purposes as the prostaglandins.

  本发明公开了一种前列腺素类似物，其中C-2羧基被氨甲基或（取代氨基）甲基所替代，以及在其制备中有用的中间体和制备过程。这些类似物可用于与前列腺素相同的药理目的。