dichloro-fluoro-acetyl chloride | 354-17-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: dichloro-fluoro-acetyl chloride
• 英文别名: Dichlor-fluor-acetylchlorid；Acetyl chloride, dichlorofluoro-；2,2-dichloro-2-fluoroacetyl chloride
• CAS: 354-17-6
• 化学式: C₂Cl₃FO
• 分子量: 165.379
• InChiKey: BWAQLYSNPAWYRG-UHFFFAOYSA-N

物化性质

• 沸点：
  73.2±35.0 °C(Predicted)
• 密度：
  1.682±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dichloro-fluoro-acetyl chloride 、 在 sodium hydroxide 作用下， 生成 α,α'-Bis-(ethyl-fluordichloracetyl-amino)-p-xylol
  参考文献：
  名称：

  New Amorbacides--VI. The Preparation of some N,N'-Disubstituted-N,N'-bis(haloacyl)-1,4-xylylenediamines

  摘要：

  DOI：

  10.1021/jm50016a001
• 作为产物：
  描述：

  三氯乙酸酐 在 溴 、 三氟化锑 作用下， 生成 dichloro-fluoro-acetyl chloride 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Swarts, Bulletin de la Societe Chimique de France, 1895, vol. <3>13, p. 992

  摘要：

  DOI：

文献信息

• Synthesis of Fluorine‐Containing 3‐Aminocyclopent‐2‐enones via Intramolecular Cyclization
  作者：Elena N. Shaitanova、Igor I. Gerus、Olga A. Balabon、Viktor E. Ivasyshyn、Karen V. Tarasenko、Constantin G. Daniliuc、Günter Haufe

  DOI：10.1002/ejoc.202001218

  日期：2020.12.13

  An optimized protocol for the preparation of fluorine‐containing acyclic enones, which react with secondary amines to form fluorinated 3‐amino‐cyclopent‐2‐enones via 4‐amino‐2,3‐dihydrofuran‐2‐ols was developed. A plausible mechanism is proposed.

  开发了一种优化的制备含氟无环烯酮的方案，该环烯酮与仲胺反应，通过4-氨基-2,3-二氢呋喃-2-醇形成氟化的3-氨基环戊-2-烯酮。提出了一种合理的机制。
• Kinetics and Mechanism of the Thermal Gas-Phase Oxidation of Tetrachloroethene by Molecular Oxygen in Presence of Trifluoromethylhypofluorite, CF₃OF
  作者：Joanna Czarnowski

  DOI：10.1524/zpch.1998.203.part_1_2.183

  日期：1998.1.1

  The oxidation of tetrachloroethene by molecular oxygen in presence of CF3OF has been studied at 314.0, 324.2, 334.1 and 344.3 K. The initial pressure of CF3OF was varied between 2.0 and 8.2 Torr, that of CCl2CCl2 between 8.7 and 21.7 Torr, that of O-2 between 33.2 and 730.7 Torr. Several runs were made adding N-2 at pressure Varying between 250.4 and 525.9 Torr. The major products were CCl3C(O)Cl and COCl2. CF3OCCl2C(O)Cl, CCl2FC(O)Cl, CF3OCCl2CCl2F and CCl2FCCl2F were formed in traces. The oxidation is a chain reaction. Its rate increases with total pressure. The following mechanism, where E = CCl2CCl2, R = CCl2FCCl2, CF3OCCl2CCl2 or CCl,3CCl2, R' = CCl2F, CF3OCCl2 or CCl3 and M = effective pressure, explains the experimental results:1) CF3OF+E-->R+CF3O 2) CF3O+E-->R3, 7) R+O-2+M-->RO2+M 4,8) 2RO(2)-->2RO+O-25) RO-->R'C(O)Cl+Cl 6) Cl+E-->CCl3CCl29) CCl3CCl2O-->CCl3C(O)Cl+Cl 10) CCl3CCl2O-->CCl3+COCl211) CCl3+O-2+M-->CCl3O2+M 12)CCl3O2+RO2-->CCl3O+RO+O-213) CCl3O-->COCl2+Cl 14) 2R-->recombination products,15) R+CF3OF-->RF+CF3Ok(9)=(3.0+/-1.4)X10(13)exp(-9.66+/-1 kcal mol(-1)/RT) s(-1).
• The Mechanism of Fluorination. I. Fluorine Sensitized Oxidation of Trichloro- and Tetrachloroethylene
  作者：William T. Miller、Albert L. Dittman

  DOI：10.1021/ja01593a039

  日期：1956.6
• Swarts, Bulletin de la Societe Chimique de France, 1895, vol. <3>13, p. 992
  作者：Swarts

  DOI：——

  日期：——
• New Amorbacides--VI. The Preparation of some N,N'-Disubstituted-N,N'-bis(haloacyl)-1,4-xylylenediamines
  作者：Alexander R. Surrey、J. Richard Mayer

  DOI：10.1021/jm50016a001

  日期：1961.5