2,2'-dichlorodiphenyl ether | 7024-98-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-dichlorodiphenyl ether
• 英文别名: bis(o-chlorophenyl)ether；2-chlorophenyl ether；Bis-(2-chlor-phenyl)-ether；1-Chloro-2-(2-chlorophenoxy)benzene
• CAS: 7024-98-8
• 化学式: C₁₂H₈Cl₂O
• 分子量: 239.101
• InChiKey: MFJMZOUFSWSBNV-UHFFFAOYSA-N

物化性质

• 沸点：
  282.2±25.0 °C(Predicted)
• 密度：
  1.300±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  邻氯苯酚 、 2-氯苯基硼酸 在 copper diacetate 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以8%的产率得到2,2'-dichlorodiphenyl ether
  参考文献：
  名称：

  Copper-mediated synthesis of mono- and dichlorinated diaryl ethers

  摘要：

  An efficient synthesis of polychlorinated diphenyl ethers (PCDEs) using the Cu(OAc)(2)-catalyzed Chan-Lam coupling reaction is described. A library of all possible mono- and dichlorinated diphenyl ether congeners was prepared and characterized using MS, H-1, and C-13 NMR spectroscopy, and Kovats retention indices. Our approach, using the optimized reaction conditions (i.e., reaction temperature, oxidizing atmosphere and base), significantly improves and simplifies the process compared to previously reported syntheses. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.06.035

文献信息

• Process for the synthesis of prostaglandin derivatives
  申请人：Technopharma S.A.

  公开号：EP1721894A1

  公开（公告）日：2006-11-15

  An alternative method for the synthesis of prostaglandin F analogues, in particular, analogues of PGF2α and specifically for the synthesis of latano-prost, wherein the transformation of the lactone intermediate (5) into the corresponding lactol (7) is carried out by treating the lactone intermediate (5) with a silane, preferably polymethylhydrosiloxane (PMHS), in the presence of a titanocene - and preferably titanocene fluoride. The method enables considerable production economies with respect to the conventional reduction of lactone with diisobutylaluminum hydride (DIBAL-H).

  一种合成前列腺素F类似物的方法，特别是PGF2α类似物，特别是用于合成拉坦前列腺素，其中通过用硅烷处理乳内中间体(5)，优选使用聚甲基氢硅氧烷(PMHS)，在存在钛烯化合物，最好是钛烯氟化物的情况下，将乳内中间体(5)转化为相应的乳糖(7)。 该工艺与二异丁基氢化铝(DIBAL-H)还原内酯相比，可显著降低生产成本。
• [EN] OXIME ESTER PHOTOINITIATORS<br/>[FR] PHOTO-INITIATEURS A BASE D'ESTER D'OXIME
  申请人：CIBA SC HOLDING AG

  公开号：WO2006018405A1

  公开（公告）日：2006-02-23

  Compounds of the formula (I), wherein R1, R2 and R10 independently of one another are C1-C20alkyl, phenyl, C1-C12alkylphenyl or phenyl-C1-C6alkyl; R3 and R4 independently of one another are hydrogen, C1-C20alkyl, NR6R7 or SR8, provided that at least one of R3 or R4 is NR6R7 or SR8; R5 is hydrogen or C1-C20alkyl; R6 and R7 independently of one another are C1-C20alkyl, or R6 and R7 together with the N-atom to which they are attached form a 5 or 6 membered ring, which optionally is interrupted by O, S or NR9 and which optionally additionally is substituted by one or more C1-C4alkyl; R8 is phenyl, biphenylyl, naphthyl, anthryl or phenanthryl, all of which optionally are substituted by one or more C1-C4alkyl; and R9 is hydrogen, C1-C20alkyl, C2-C4hydroxyalkyl or phenyl; exhibit an unexpectedly good performance in photopolymerization reactions.

  式(I)的化合物，其中R1、R2和R10各自独立地为C1-C20烷基、苯基、C1-C12烷基苯基或苯基-C1-C6烷基；R3和R4各自独立地为氢、C1-C20烷基、NR6R7或SR8，但至少其中之一为NR6R7或SR8；R5为氢或C1-C20烷基；R6和R7各自独立地为C1-C20烷基，或者R6和R7连同它们所连接的N原子形成一个5或6元环，该环可选地被O、S或NR9打断，并且该环可选地另外被一个或多个C1-C4烷基取代；R8为苯基、联苯基、萘基、蒽基或菲基，所有这些基团可选地被一个或多个C1-C4烷基取代；R9为氢、C1-C20烷基、C2-C4羟基烷基或苯基。这些化合物在光聚合反应中表现出意外的良好性能。
• Polyphenylene ether resin compositions containing halogenated aromatic compound alone as a flame retardant agent
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0129762A2

  公开（公告）日：1985-01-02

  Flame retardant compositions comprising admixtures of polyphenylene ether resin, a polyalkenyl aromatic and as the sole flame retardant agent, a halogenated aromatic compound or mixture of such compounds, are described. These provide decided advantages over corresponding flame retardant compositions containing synergistic agents and/or aromatic phosphate flame retardants, alone, or in combina- tion with halogenated aromatics. They are useful for shaping into a wide variety of articles for industrial or household purposes.

  阻燃剂组合物包括聚苯醚树脂、聚烯芳烃和作为唯一阻燃剂的卤代芳烃化合物或此类化合物混合物的混合物。与含有增效剂和/或芳香族磷酸酯阻燃剂（单独使用或与卤代芳香烃混合使用）的相应阻燃组合物相比，这些产品具有明显的优势。它们可用于制作各种工业或家用物品。
• Human nerve growth factor gene segment
  申请人：Tosoh Corporation

  公开号：EP0329175A1

  公开（公告）日：1989-08-23

  A novel gene segment that codes for human nerve growth factor and a method of production thereof, a recombinant plasmid containing the gene segment, a microorganism holding the recombinant plasmid in the cells, a method of producing human nerve growth factor by use of the microorganism and a novel human nerve growth factor fused protein which is to be produced by the method.

  一种编码人类神经生长因子的新型基因片段及其生产方法，一种含有该基因片段的重组质粒，一种在细胞中含有该重组质粒的微生物，一种利用该微生物生产人类神经生长因子的方法，以及一种通过该方法生产的新型人类神经生长因子融合蛋白。
• Process for preparing polyarylene thioethers
  申请人：SEISAN KAIHATSU KAGAKU KENKYUSHO

  公开号：EP0440106A2

  公开（公告）日：1991-08-07

  Polyarylene thioethers are easily prepared by an oxidative polymerization of an aromatic compound of the formula (I) wherein R¹, R², R³ and R⁴ are each independently a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, and Y is a hydrogen atom or a group of the formula (II) wherein R⁵, R⁶, R⁷ and R⁸ are each independently a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group and X is -O-, -S-, a methylene group or an ethylene group with a sulfidizing agent in the presence of an acid and an oxidizing agent, or in the presence of an acid, a catalyst for oxidative polymerization and oxygen, or in the presence of a Friedel-Crafts catalyst.

  通过式 (I) 的芳香族化合物的氧化聚合可轻松制备聚芳硫醚，式 (I) 中 R¹、R²、R³ 和 R⁴ 各自独立地为氢原子、卤素原子、低级烷基或低级烷氧基，Y 为氢原子或式 (II) 的基团，式 (II) 中 R⁵、R⁶、 R⁵、R⁶、R⁷ 和 R⁸ 各自独立地为氢原子、卤素原子、低级烷基或低级烷氧基，X 为-O-、-S-、亚甲基或亚乙基，在有酸和氧化剂存在下，或在有酸、氧化聚合催化剂和氧存在下，或在有 Friedel-Crafts 催化剂存在下，加入硫化剂。