N,N-dibenzylhydroxylamine hydrochloride | 20438-95-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-dibenzylhydroxylamine hydrochloride
• 英文别名: N,N-dibenzyl-hydroxylamine; hydrochloride；N,N-Dibenzyl-hydroxylamin; Hydrochlorid；{[Benzyl(hydroxy)amino]methyl}benzene hydrochloride；N,N-dibenzylhydroxylamine;hydrochloride
• CAS: 20438-95-3
• 化学式: C₁₄H₁₅NO*ClH
• 分子量: 249.74
• InChiKey: ZMKVKLAJTFYFNG-UHFFFAOYSA-N

物化性质

• 熔点：
  178-179 °C(Solv: ethanol (64-17-5))

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  23.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-dibenzylhydroxylamine hydrochloride 、 丙烯醛 以 苯 为溶剂， 反应 72.0h， 生成 3-N,N-dibenzylhydroxylaminopropanal
  参考文献：
  名称：

  Synthesis of 2,2-dialkyl-5-hydroxyisoxazolidinium and 1,1-Dialkyl-3-hydroxypyrazolidinium salts

  摘要：

  Salts of N,N-dialkylhydroxylamines and beta-dialkylhydrazides react with acrolein to give 2,2-dialkyl-5-hydroxyisoxazolidinium and 1,1-dialkyl-3-hydroxypyrazolidinium salts.

  DOI：

  10.1016/s0040-4039(00)78880-0
• 作为产物：
  描述：

  N,N-二苄基羟胺 在 盐酸 作用下， 以 正庚烷 、 异丙醇 为溶剂， 以68%的产率得到N,N-dibenzylhydroxylamine hydrochloride
  参考文献：
  名称：

  [EN] STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS, TEXTILES AND FABRICS
  [FR] PRODUITS DE SOINS CORPORELS, PRODUITS MENAGERS, TEXTILES ET TISSUS STABILISES

  摘要：

  公开号：

  WO2005041905A3

文献信息

• Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease
  申请人：F. HOFFMANN-LA ROCHE LTD

  公开号：US20130102601A1

  公开（公告）日：2013-04-25

  The present invention relates to a compound having the general formula II, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

  本发明涉及具有通式II的化合物，可选地以药学上可接受的盐、溶剂合物、多型体、前药、互变异构体、消旋体、对映体或二对映体或其混合物的形式存在，用于治疗、改善或预防病毒性疾病。此外，还披露了特定的联合疗法。
• [EN] WATER COMPATIBLE STERICALLY HINDERED ALKOXYAMINES AND HYDROXY SUBSTITUTED ALKOXYAMINES<br/>[FR] ALCOXYAMINES STERIQUEMENT ENCOMBREES ET ALCOXYAMINES HYDROXY SUBSTITUEES HYDROCOMPATIBLES
  申请人：CIBA SC HOLDING AG

  公开号：WO2004076419A1

  公开（公告）日：2004-09-10

  Sterically hindered alkoxyamine and hydroxy substituted alkoxyamine stabilizer compounds are made water compatible via certain backbones with affinity towards water. The sterically hindered amines are for example of the formula where for example E and E’ are 2-hydroxycydohexyloxy, 2-hydroxy-2-methylpropoxy, benzyloxy, methoxy, propoxy, hexyloxy, heptyloxy, oclyloxy or cyclohexyloxy, Rx is for example -NH2+CH2CH20H Cl-, -NH3+ -OAc, =NOH, -NHCH(CH3)COO-K+,- NHCH2CH2NH(CH3)2+ -OAC, -NHCH2CH2SO3-K+, -NHCH(COO- K+)CH2CH2SCH3, -NHCH2COO- K+, -OCH(CH3)COO-K+, -OCH2CH2NH(CH3)2+ -OAC, -OCH2CH2SO3-K+, -OCH(COO- K+)CH2CH2SCH3 or -OCH2COO-K+, and where R5 comprises repeating units of -(OCH2CH2)-, -(OCH2CH2(CH3))-,-(CH2CHCOOH)-, -(CH2C(CH3)COOH)-, -(CH2CHCOOCH3)-, -(NHCH2CH2)-, -(CH2CHOH)-, -(CH2CHCONH2)-or -(CH2CH(NHCOH))-. These compounds are particularly effective in stabilizing aqueous polymer systems against the deleterious effects of oxidative, thermal and actinic radiation. The compounds are effective for example in stabilizing water borne coatings, aqueous inks, aqueous inkjet media and photocured aqueous systems.

  通过具有亲水性的特定骨架，使具有立体位阻的烷氧胺和羟基取代的烷氧胺稳定剂化合物与水相容。其中，立体位阻胺的示例为以下公式，其中 E 和 E’ 为 2-羟基环己氧基、2-羟基-2-甲基丙氧基、苄氧基、甲氧基、丙氧基、己氧基、庚氧基、辛氧基或环己氧基，Rx 为例如 -NH2+CH2CH20H Cl-, -NH3+ -OAc, =NOH, -NHCH(CH3)COO-K+,- NHCH2CH2NH(CH3)2+ -OAC, -NHCH2CH2SO3-K+, -NHCH(COO- K+)CH2CH2SCH3, -NHCH2COO- K+, -OCH(CH3)COO-K+, -OCH2CH2NH(CH3)2+ -OAC, -OCH2CH2SO3-K+, -OCH(COO- K+)CH2CH2SCH3 或 -OCH2COO-K+，R5 包括重复单元 -(OCH2CH2)-, -(OCH2CH2(CH3))-,-(CH2CHCOOH)-, -(CH2C(CH3)COOH)-, -(CH2CHCOOCH3)-, -(NHCH2CH2)-, -(CH2CHOH)-, -(CH2CHCONH2)- 或 -(CH2CH(NHCOH))-. 这些化合物在稳定水性聚合物体系抵抗氧化、热和光辐射的有害影响方面特别有效。这些化合物例如在稳定水性涂料、水性油墨、水性喷墨介质和光固化水性系统方面非常有效。
• Ink jet ink and recording material
  申请人：Wood G. Mervin

  公开号：US20060040074A1

  公开（公告）日：2006-02-23

  The present invention relates to an ink jet ink, an ink jet recording material or an ink jet system comprising at least one sterically hindered N-hydroxylamine strong acid salt, for example 1-hydroxy-2,2,6,6-tetramethyl-4-hydroxypiperidinium chloride or bis(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl) sebacate dihydrochloride; or comprising at least one dialkyl N-hydroxylamine salt, for example chloride, bisulfate, sulfate, phosphate, nitrate, ascorbate, formate, acetate, benzoate, oxalate, citrate, a carboxylate of ethylenediaminetetraacetic acid or of diethylenetriaminepentaacetic acid or polyacrylate salts of N,N-diethylhydroxylamine, N,N-bis(2-hydroxypropyl)hydroxylamine, N,N-bis(3-hydroxypropyl)hydroxylamine, N,N-dibenzylhydroxylamine or the N,N-di(alkyl)hydroxylamine produced by the direct oxidation of N,N-di(hydrogenated tallow)amine.

  本发明涉及一种喷墨墨水、一种喷墨记录材料或一种喷墨系统，它包含至少一种立体受阻的 N-羟胺强酸盐，例如 1-羟基-2,2,6,6-四甲基-4-羟基哌啶氯化物或双(1-羟基-2,2,6,6-四甲基哌啶-4-基)癸二酸二盐酸盐；或包含至少一种 N-羟胺二烷基盐，例如氯化物、硫酸氢盐、硫酸盐、磷酸盐、硝酸盐、抗坏血酸盐、甲酸盐、醋酸盐、苯甲酸盐、草酸盐、柠檬酸盐、乙二胺四乙酸或二乙烯三胺五乙酸的羧酸盐或 N.....、N,N-二乙基羟胺、N,N-二(2-羟基丙基)羟胺、N,N-二(3-羟基丙基)羟胺、N,N-二苄基羟胺或由 N,N-二(氢化牛脂基)胺直接氧化产生的 N,N-二(烷基)羟胺的聚丙烯酸盐。
• 1,1-Dialkyl-2-acyl-3-hydroxypyrazolidinium and 2,2-dialkyl-5-hydroxyisoxazolidinium salts
  作者：K. N. Zelenin、L. F. Mel'nikova、I. P. Bezhan、I. V. Lagoda、B. A. Chakchir

  DOI：10.1007/bf02251546

  日期：1998.9
• INK-JET INK AND RECORDING MATERIAL
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1572817B1

  公开（公告）日：2007-03-21