{2-[1-methyl-2-(trimethylsilyl)ethyl]phenyl}amine | 607375-22-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: {2-[1-methyl-2-(trimethylsilyl)ethyl]phenyl}amine
• 英文别名: 2-(1-Methyl-2-trimethylsilylethyl)phenylamine；2-(1-trimethylsilylpropan-2-yl)aniline
• CAS: 607375-22-4
• 化学式: C₁₂H₂₁NSi
• 分子量: 207.391
• InChiKey: WPYIVUAYWQXGDD-UHFFFAOYSA-N

物化性质

• 沸点：
  278.5±15.0 °C(Predicted)
• 密度：
  0.913±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.71
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯胺 、 烯丙基三甲基硅烷 在 aluminum (III) chloride 、 氢化铝 、 sodium hydroxide 作用下， 以 水 、 甲苯 为溶剂， 反应 10.25h， 生成 {2-[1-methyl-2-(trimethylsilyl)ethyl]phenyl}amine
  参考文献：
  名称：

  [DE] SILYLIERTE CARBOXAMIDE
  [EN] SILYLATED CARBOXAMIDES
  [FR] CARBOXAMIDES SILYLES

  摘要：

  新的硅烷化羧酰胺化合物，其化学式为（I），其中R、L、R1、R2、R3、R4和A具有描述中所指定的含义，以及制备这些化合物的多种方法以及它们用于对抗不良微生物的用途。

  公开号：

  WO2005049624A1

文献信息

• Silylated carboxamides
  申请人：Dunkel Ralf

  公开号：US20070191454A1

  公开（公告）日：2007-08-16

  Novel silylated carboxamides of the formula (I) in which R, L, R 1 , R 2 , R 3 , R 4 and A are as defined in the description, a plurality of processes for preparing these compounds and their use for controlling unwanted microorganisms.

  新颖的硅烷化羧酰胺化合物的化学式（I），其中R、L、R1、R2、R3、R4和A的定义如描述中所示，提供了多种制备这些化合物的方法，以及它们用于控制不受欢迎微生物的用途。
• Siliconated phenyl amides derivatives useful as microbiocide
  申请人：Syngenta Crop Protection, Inc.

  公开号：US07767623B2

  公开（公告）日：2010-08-03

  A fungicidal compound of formula (1): where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by groups R7, R8 and R9; R1 is hydrogen, optionally substituted (C1-4)alkylC(═O), optionally substituted (C1-4)alkylC(═O)O, optionally substituted (C1-4)alkoxy(C1-4)alkyl, optionally substituted allyl, optionally substituted propargyl or optionally substituted allenyl; R2, R3, R4and R5 are each, independently, hydrogen, halogen, optionally substituted (C1-4)alkoxy(C1-4)alkoxy or optionally substituted (C1-4)alkoxy(C1-4)alkyl; R6 is an organic group containing three to thirteen carbon atoms and at least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and is optionally substituted by one to four independently selected halogen atoms; R7, R8 and R9are each, independently, hydrogen, halogen, C1-3alkyl, C1-3haloalkyl, C1-3alkoxy(C1-3)alkyl or cyano, where at least one of R7, R8and R9 is not hydrogen; and X is O or S; or an N-oxide thereof; and when present, each optional substituent on alkyl moieties, allyl, propargyl and allenyl is, independently, selected from halogen, hydroxy, cyano, methoxycarbonyl, ethoxycarbonyl, methoxy, ethoxy, methylsulfonyl, ethylsulfonyl, diflouromethoxy, trifluoromethoxy and trifluorothiomethoxy.

  化合物的杀菌配方（1）：其中Het是一个含有一个至三个杂原子的5或6元杂环，每个杂原子独立地从氧，氮和硫中选择，该环被R7，R8和R9基取代; R1是氢，可选取代（C1-4）烷基C（═O），可选取代（C1-4）烷基C（═O）O，可选取代（C1-4）烷氧基（C1-4）烷基，可选取代烯丙基，可选取代丙炔基或可选取代异丙炔基; R2，R3，R4和R5各自独立地是氢，卤素，可选取代（C1-4）烷氧基（C1-4）烷氧基或可选取代（C1-4）烷氧基（C1-4）烷基; R6是含有三到十三个碳原子和至少一个硅原子的有机基团，以及可选取一个至三个杂原子，每个杂原子独立地从氧，氮和硫中选择，并且可选取一到四个独立选择的卤素原子进行取代; R7，R8和R9各自独立地是氢，卤素，C1-3烷基，C1-3卤烷基，C1-3烷氧基（C1-3）烷基或氰基，其中至少一个R7，R8和R9不是氢; X是O或S; 或其N-氧化物; 当存在时，烷基，烯丙基，丙炔基和异丙炔基上的每个可选取代基团各自独立地从卤素，羟基，氰基，甲氧基羰基，乙氧基羰基，甲氧基，乙氧基，甲磺酰基，乙磺酰基，二氟甲氧基，三氟甲氧基和三氟硫代甲氧基中选择。
• Chemical compounds
  申请人：Ehrenfreund Josef

  公开号：US08357816B2

  公开（公告）日：2013-01-22

  A fungicidal compound of formula (I): where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by groups R7, R8 and R9; R1 is hydrogen, optionally substituted (C1-4alkyl, optionally substituted (C1-4alkylC(═O), optionally substituted (C1-4alkylC(═O)O, optionally substituted (C1-4)alkoxy(C1-4)alkyl, optionally substituted allyl, optionally substituted propargyl or optionally substituted allenyl; R2, R3, R4 and R5 are each, independently, hydrogen, halogen, optionally substituted (C1-4)alkyl, optionally substituted (C1-4)alkoxy or optionally substituted (C1-4)alkoxy(C1-4alkyl; R6 is an organic group containing three to thirteen carbon atoms and at least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and is optionally substituted by one to four independently selected halogen atoms; R7, R8 and R9 are each, independently, hydrogen, halogen, C1-3 alkyl, C1-3 haloalkyl, C1-3alkoxy(C1-3)alkyl or cyano, where at least one of R7, R8 and R9 is not hydrogen; and X is O or S; or an N-oxide thereof; and when present, each optional substituent on alkyl moieties, allyl, propargyl and allenyl is, independently, selected from halogen, hydroxy, cyano, methoxycarbonyl, ethoxycarbonyl, methoxy, ethoxy, methylsulfonyl, ethylsulfonyl, difluoromethoxy, trifluoromethoxy and trifluorothiomethoxy.

  式(I)的一种杀真菌化合物：其中，Het是一个含有1~3个杂原子的5-或6-元杂环，每个杂原子独立地从氧、氮和硫中选择，该环被R7、R8和R9基取代；R1是氢，可选择性取代的(C1-4)烷基，可选择性取代的(C1-4)烷基C(═O)，可选择性取代的(C1-4)烷基C(═O)O，可选择性取代的(C1-4)烷氧基(C1-4)烷基，可选择性取代的烯丙基，可选择性取代的丙炔基或可选择性取代的芳基；R2、R3、R4和R5各自独立地是氢、卤素、可选择性取代的(C1-4)烷基、可选择性取代的(C1-4)烷氧基或可选择性取代的(C1-4)烷氧基(C1-4)烷基；R6是一个含有3~13个碳原子和至少一个硅原子的有机基团，并且可选择性地含有1~3个杂原子，每个杂原子独立地从氧、氮和硫中选择，并且可选择性地被1~4个独立选择的卤素原子取代；R7、R8和R9各自独立地是氢、卤素、C1-3烷基、C1-3卤代烷基、C1-3烷氧基(C1-3)烷基或氰基，其中至少有一个R7、R8和R9不是氢；X是O或S；或其N-氧化物。当存在于烷基、烯丙基、丙炔基和芳基上的任何可选择性取代基时，每个取代基均独立地从卤素、羟基、氰基、甲氧羰基、乙氧羰基、甲氧基、乙氧基、甲基磺酰基、乙基磺酰基、二氟甲氧基、三氟甲氧基和三氟硫代甲氧基中选择。
• CHEMICAL COMPOUNDS
  申请人：Ehrenfreund Josef

  公开号：US20100305351A1

  公开（公告）日：2010-12-02

  A fungicidal compound of formula (I): where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by groups R 7 , R 8 and R 9 ; R 1 is hydrogen, optionally substituted (C 1-4 alkyl, optionally substituted (C 1-4 alkylC(═O), optionally substituted (C 1-4 alkylC(═O)O, optionally substituted (C 1-4 )alkoxy(C 1-4 )alkyl, optionally substituted allyl, optionally substituted propargyl or optionally substituted allenyl; R 2 , R 3 , R 4 and R 5 are each, independently, hydrogen, halogen, optionally substituted (C 1-4 )alkyl, optionally substituted (C 1-4 )alkoxy or optionally substituted (C 1-4 )alkoxy(C 1-4 alkyl; R 6 is an organic group containing three to thirteen carbon atoms and at least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and is optionally substituted by one to four independently selected halogen atoms; R 7 , R 8 and R 9 are each, independently, hydrogen, halogen, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy(C 1-3 )alkyl or cyano, where at least one of R 7 , R 8 and R 9 is not hydrogen; and X is O or S; or an N-oxide thereof; and when present, each optional substituent on alkyl moieties, allyl, propargyl and allenyl is, independently, selected from halogen, hydroxy, cyano, methoxycarbonyl, ethoxycarbonyl, methoxy, ethoxy, methylsulfonyl, ethylsulfonyl, difluoromethoxy, trifluoromethoxy and trifluorothiomethoxy.

  化合物的式子为（I）：其中Het是一个含有1-3个杂原子的5-或6元杂环，每个杂原子独立地选自氧、氮和硫，该环被R7、R8和R9基团取代；R1是氢，可选地取代（C1-4）烷基，可选地取代（C1-4）烷基C（═O），可选地取代（C1-4）烷基C（═O）O，可选地取代（C1-4）烷氧基（C1-4）烷基，可选地取代烯丙基，可选地取代丙炔基或可选地取代异戊烯基；R2、R3、R4和R5分别是氢、卤素、可选地取代的（C1-4）烷基、可选地取代的（C1-4）烷氧基或可选地取代的（C1-4）烷氧基（C1-4）烷基；R6是一个有机基团，含有3-13个碳原子和至少一个硅原子，可选地含有1-3个杂原子，每个杂原子独立地选自氧、氮和硫，可选地被1-4个独立选择的卤素原子取代；R7、R8和R9分别是氢、卤素、C1-3烷基、C1-3卤代烷基、C1-3烷氧基（C1-3）烷基或氰基，其中至少有一个不是氢；X是O或S；或其N-氧化物；当存在时，烷基、烯丙基、丙炔基和异戊烯基上的每个可选取代基团独立地选自卤素、羟基、氰基、甲氧羰基、乙氧羰基、甲氧基、乙氧基、甲磺酰基、乙磺酰基、二氟甲氧基、三氟甲氧基和三氟硫代甲氧基。