6-methoxy-1-(1-methylethoxy)-2-naphthalenecarboxylic acid | 117666-75-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-methoxy-1-(1-methylethoxy)-2-naphthalenecarboxylic acid
• 英文别名: 6-methoxy-1-propan-2-yloxynaphthalene-2-carboxylic acid
• CAS: 117666-75-8
• 化学式: C₁₅H₁₆O₄
• 分子量: 260.29
• InChiKey: KFKWQUHZSRWQES-UHFFFAOYSA-N

物化性质

• 沸点：
  410.4±30.0 °C(Predicted)
• 密度：
  1.196±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-氨基四氮唑 、 6-methoxy-1-(1-methylethoxy)-2-naphthalenecarboxylic acid 在 N,N'-羰基二咪唑 作用下， 生成 6-methoxy-1-propan-2-yloxy-N-(2H-tetrazol-5-yl)naphthalene-2-carboxamide
  参考文献：
  名称：

  Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents

  摘要：

  The synthesis and antiallergic activity of a series of novel benzothiophene-, benzofuran-, and naphthalenecarbox-amidotetrazoles are described. A number of the compounds inhibit the release of histamine from anti-IgE stimulated basophils obtained from allergic donors. Optimal inhibition is exhibited in benzothiophenes with a 3-alkoxy substituent in combination with a 5-methoxy, 6-methoxy, or a 5,6-dimethoxy group. Compounds 13c (CI-959) also inhibited respiratory burst of human neutrophils and the release of mediators from anti-IgE-stimulated human chopped lung.

  DOI：

  10.1021/jm00083a023
• 作为产物：
  描述：

  methyl 6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate 在 氢氧化钾 、 N-溴代丁二酰亚胺(NBS) 、 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile 、 potassium tert-butylate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 、 甲醇 、 氯仿 、 二甲基亚砜 为溶剂， 反应 29.0h， 生成 6-methoxy-1-(1-methylethoxy)-2-naphthalenecarboxylic acid
  参考文献：
  名称：

  Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents

  摘要：

  The synthesis and antiallergic activity of a series of novel benzothiophene-, benzofuran-, and naphthalenecarbox-amidotetrazoles are described. A number of the compounds inhibit the release of histamine from anti-IgE stimulated basophils obtained from allergic donors. Optimal inhibition is exhibited in benzothiophenes with a 3-alkoxy substituent in combination with a 5-methoxy, 6-methoxy, or a 5,6-dimethoxy group. Compounds 13c (CI-959) also inhibited respiratory burst of human neutrophils and the release of mediators from anti-IgE-stimulated human chopped lung.

  DOI：

  10.1021/jm00083a023

文献信息

• N-1H-tetrazol-5-yl-2-naphthalene carboxamides and their use as
  申请人：Warner-Lambert Company

  公开号：US04767776A1

  公开（公告）日：1988-08-30

  Novel naphthalene derivatives having antiallergy and antiinflammatory activity.

  具有抗过敏和抗炎活性的新萘衍生物。
• 1-ether and 1-thioether-naphthalene-2-carboxamides as inhibitors of cell
  申请人：Warner-Lambert Company

  公开号：US05434188A1

  公开（公告）日：1995-07-18

  1-Ether and 1-thioether-naphthalene-2-carboxamides are described, methods of manufacture therefor and their use as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases, and their utility in inhibiting the activation of human immunodeficiency virus (HIV), latent in infected humans.

  本文描述了一种以太和一种硫醚萘-2-羧酰胺，以及它们的制造方法和用途，作为抑制白细胞黏附于血管内皮的药物，因此可作为治疗炎症性疾病的有效治疗药物，并在抑制患有人类免疫缺陷病毒（HIV）的患者中激活的潜伏病毒方面具有实用价值。
• Novel naphthalene derivatives and antiallergy and anti-inflammatory pharmaceuticals
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0279466A2

  公开（公告）日：1988-08-24

  Novel naphthalene derivatives of the formula (I): having antiallergy and antiinflammatory activity.

  式 (I) 的新型萘衍生物： 具有抗过敏和抗炎活性。
• CONNOR, DAVID T.;UNANGST, PAUL C.;WEIKERT, ROBERT J.
  作者：CONNOR, DAVID T.、UNANGST, PAUL C.、WEIKERT, ROBERT J.

  DOI：——

  日期：——
• US4767776A
  申请人：——

  公开号：US4767776A

  公开（公告）日：1988-08-30