3-benzyltetrahydro-1,4,3-oxathiazine 4,4-dioxide | 21805-25-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-benzyltetrahydro-1,4,3-oxathiazine 4,4-dioxide
• 英文别名: 3-Benzyl-1,4,3-oxathiazinane 4,4-dioxide；3-benzyl-1,4,3-oxathiazinane 4,4-dioxide
• CAS: 21805-25-4
• 化学式: C₁₀H₁₃NO₃S
• 分子量: 227.284
• InChiKey: ADQFQBSQVJBUET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-benzyltetrahydro-1,4,3-oxathiazine 4,4-dioxide 在 氢气 、 铂 作用下， 生成 GP-2250 、 甲基环己烷 、 甲苯
  参考文献：
  名称：

  [EN] OXATHIAZINE DERIVATIVES AS ANTIBACTERIAL AND ANTICANCER AGENTS
  [FR] DÉRIVÉS D'OXATHIAZINE À TITRE D'AGENTS ANTIBACTÉRIENS ET ANTICANCÉREUX

  摘要：

  新的类似于氧硫唑的化合物及其衍生物可作为抗肿瘤和抗微生物药物使用。

  公开号：

  WO2013190355A1
• 作为产物：
  描述：

  聚合甲醛 、 N-苄基甲烷磺酰胺 在 正丁基锂 作用下， 生成 3-benzyltetrahydro-1,4,3-oxathiazine 4,4-dioxide
  参考文献：
  名称：

  A Convenient Synthesis of 5-Substituted Tetrahydro-1,4,3-oxathiazine 4,4-Dioxides

  摘要：

  An advantageous one pot procedure for the synthesis of tetrahydro-1,4,3-oxathiazine 4,4-dioxides by dialkylation of readily available alpha,N-alkyl-or arylsulfonamide dianions with gaseous formaldehyde is reported. Stability and some reactions of these heterocycles are also described.

  DOI：

  10.3987/com-92-6207

文献信息

• Processes for preparing oxathiazin-like compounds
  申请人：GEISTLICH PHARMA AG

  公开号：US10968190B2

  公开（公告）日：2021-04-06

  Methods for producing compounds useful in reactions to produce oxathiazin-like compounds are disclosed including a process of adding sodium 2-bromoethanesulfonate to a solution of benzyl alcohol and sodium benzyloxide to for mixture, boiling the mixture to reflux four times, concentrating under vacuum until dry, boiling with ethyl alcohol, filtering the ethyl alcohol, and concentrating to dryness to obtain solid sodium 2-benzyletherethanesulfonate.

  公开了用于生产噁噻嗪类化合物反应的化合物的生产方法，包括向苄醇和苄氧 化钠的溶液中加入 2-溴乙基磺酸钠至混合物，将混合物煮沸至回流四次，在真空下浓缩 至干，用乙醇煮沸，过滤乙醇，浓缩至干，得到固体 2-苄基乙基磺酸钠。
• OXATHIAZINE DERIVATIVES AS ANTIBACTERIAL AND ANTICANCER AGENTS
  申请人：GEISTLICH PHARMA AG

  公开号：US20150182534A1

  公开（公告）日：2015-07-02

  New oxathiazin-like compounds and their derivatives are useful as antineoplastic and antimicrobial agents.
• PROCESSES FOR PREPARING OXATHIAZIN-LIKE COMPOUNDS
  申请人：GEISTLICH PHARMA AG

  公开号：US20210163432A1

  公开（公告）日：2021-06-03

  Oxathiazin-like compounds, processes for making new oxathiazin-like compounds, compounds useful for making oxathiazin-like compounds, and their uses are disclosed. Processes of treating patients suffering from cancers, bacterial infections, fungal infections and/or viral infections by administering oxathiazin-like compounds are also disclosed. These compounds were found to have significantly longer half-life compared to taurolidine and taurultam.
• US9241943B2
  申请人：——

  公开号：US9241943B2

  公开（公告）日：2016-01-26
• US9624187B2
  申请人：——

  公开号：US9624187B2

  公开（公告）日：2017-04-18