N-(4-chloro-3-fluorophenyl)imidazole-1-carboxamide | 1518128-55-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-chloro-3-fluorophenyl)imidazole-1-carboxamide
• CAS: 1518128-55-6
• 化学式: C₁₀H₇ClFN₃O
• 分子量: 239.636
• InChiKey: RONMSPLJQWJUFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  、 N-(4-chloro-3-fluorophenyl)imidazole-1-carboxamide 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 4-((3-chloro-5-(3-(4-chloro-3-fluorophenyl)ureido)-1H-indol-1-yl)methyl)-N-methylpicolinamide
  参考文献：
  名称：

  Design, synthesis and biological evaluation of indole derivatives as novel inhibitors targeting B-Raf kinase

  摘要：

  A series of novel indole derivatives were designed and synthesized and their inhibitory activity against B-Raf and HepG2 cell were also described. Among them, compounds 7a and 7b exhibited excellent potency, which showed the potential for further research as lead compounds. (C) 2013 Wei-Fang Tang and Tao Lu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.11.006
• 作为产物：
  描述：

  4-氯-3-氟苯胺 、 N,N'-羰基二咪唑 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 N-(4-chloro-3-fluorophenyl)imidazole-1-carboxamide
  参考文献：
  名称：

  Design, synthesis and biological evaluation of indole derivatives as novel inhibitors targeting B-Raf kinase

  摘要：

  A series of novel indole derivatives were designed and synthesized and their inhibitory activity against B-Raf and HepG2 cell were also described. Among them, compounds 7a and 7b exhibited excellent potency, which showed the potential for further research as lead compounds. (C) 2013 Wei-Fang Tang and Tao Lu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.11.006

文献信息

• Design, synthesis and biological evaluation of indole derivatives as novel inhibitors targeting B-Raf kinase
  作者：Zeng Wu、Ming Yan、Shi-He Hu、Zhi-Cheng Yu、Yong Zhu、Ya-Dong Cheng、Hai-Chun Liu、Yan-Min Zhang、Si-Hui Yao、Wei-Fang Tang、Tao Lu

  DOI：10.1016/j.cclet.2013.11.006

  日期：2014.2

  A series of novel indole derivatives were designed and synthesized and their inhibitory activity against B-Raf and HepG2 cell were also described. Among them, compounds 7a and 7b exhibited excellent potency, which showed the potential for further research as lead compounds. (C) 2013 Wei-Fang Tang and Tao Lu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.