[2-[Methyl(prop-2-ynyl)amino]phenyl]methanol | 677030-22-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-[Methyl(prop-2-ynyl)amino]phenyl]methanol
• 英文别名: [2-[methyl(prop-2-ynyl)amino]phenyl]methanol
• CAS: 677030-22-7
• 化学式: C₁₁H₁₃NO
• 分子量: 175.23
• InChiKey: DHNPPLOSLGWVBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [2-[Methyl(prop-2-ynyl)amino]phenyl]methanol 以 甲苯 为溶剂， 反应 2.0h， 生成 methyl (1S,12S)-8-methyl-8,16-diazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,10-tetraene-12-carboxylate
  参考文献：
  名称：

  An expedient synthesis of diversified pyrrolizines and indolizines

  摘要：

  A general and rapid synthesis of new families of pyrrolizines and indolizines in good overall yields via an intramolecular [3+2]cycloaddition reaction is described. Diversity of substitutions can be achieved by the appropriate choice of readily available starting materials. The experimental procedures are straightforward and are performed under neutral conditions. New syntheses are also described for the preparation of N-propargylic 2-amino-benzaldehydes and S-propargylic 2-thiobenzaldehydes. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.11.146
• 作为产物：
  描述：

  邻甲氨基苯甲酸甲酯 在 lithium aluminium tetrahydride 、 potassium carbonate 作用下， 以 乙醚 、 乙腈 为溶剂， 反应 52.0h， 生成 [2-[Methyl(prop-2-ynyl)amino]phenyl]methanol
  参考文献：
  名称：

  An expedient synthesis of diversified pyrrolizines and indolizines

  摘要：

  A general and rapid synthesis of new families of pyrrolizines and indolizines in good overall yields via an intramolecular [3+2]cycloaddition reaction is described. Diversity of substitutions can be achieved by the appropriate choice of readily available starting materials. The experimental procedures are straightforward and are performed under neutral conditions. New syntheses are also described for the preparation of N-propargylic 2-amino-benzaldehydes and S-propargylic 2-thiobenzaldehydes. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.11.146

文献信息

• An expedient synthesis of diversified pyrrolizines and indolizines
  作者：George Bashiardes、Imad Safir、Francis Barbot、Joelle Laduranty

  DOI：10.1016/j.tetlet.2003.11.146

  日期：2004.2

  A general and rapid synthesis of new families of pyrrolizines and indolizines in good overall yields via an intramolecular [3+2]cycloaddition reaction is described. Diversity of substitutions can be achieved by the appropriate choice of readily available starting materials. The experimental procedures are straightforward and are performed under neutral conditions. New syntheses are also described for the preparation of N-propargylic 2-amino-benzaldehydes and S-propargylic 2-thiobenzaldehydes. (C) 2003 Elsevier Ltd. All rights reserved.