2,4-dibromo-6-[(2-methoxyethylamino)methyl]phenol | 1523340-61-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dibromo-6-[(2-methoxyethylamino)methyl]phenol
• CAS: 1523340-61-5
• 化学式: C₁₀H₁₃Br₂NO₂
• 分子量: 339.027
• InChiKey: SBNPFJIHIOEATG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.65
• 重原子数：
  15.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  41.49
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2,4-dibromo-6-[(2-methoxyethylamino)methyl]phenol 、 2,4-Dibrom-6-chlormethylphenol 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以60%的产率得到
  参考文献：
  名称：

  钇[氨基-烷氧基-双（酚盐）]配合物介导的高度立体控制的外消旋烷基β-丙二酸内酯的开环聚合

  摘要：

  钇[氨基-烷氧基-双（酚盐）]酰胺基络合物已用于外消旋烷基β-丙二酸内酯（4-烷氧基羰基-2-氧杂环丁烷，rac - MLA R s）的开环聚合（ROP）。全部），苄基（Bz）或甲基（Me）侧酯官能团。金属辅助物中酚盐环上的邻位取代基的性质决定了ROP的立体控制，因此决定了所得聚酯的间规富集。ROP促进通过与卤素（氯，溴）催化剂二取代的配体允许高度间同立构PMLA的首次报道合成- [R S（P - [R ≥0.95）; 相反，带有庞大烷基和芳基邻位基团的催化剂事实证明，预取代的配体无效。所有聚合物均已通过1 H和13 C { 1 H} NMR光谱，MALDI-ToF质谱和DSC分析进行了表征。统计和热分析使链端控制机制合理化。聚合的立体控制遵循rac ‐MLA Bz和rac ‐MLA All的ROP的马尔可夫一阶（Mk1）模型，而rac ‐MLA Me的ROP遵循导致了马尔可夫二阶类型（M

  DOI：

  10.1002/chem.201600223
• 作为产物：
  描述：

  3,5-二溴水杨醛 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 14.0h， 生成 2,4-dibromo-6-[(2-methoxyethylamino)methyl]phenol
  参考文献：
  名称：

  Bimetallic Zirconium Amine Bis(phenolate) Polymerization Catalysts: Enhanced Activity and Tacticity Control for Polyolefin Synthesis

  摘要：

  Binucleating multidentate amine bis(phenolate) ligands with rigid terphenyl backbones were designed to support two zirconium centers locked in dose proximity. Polymerizations of propylene or 1-hexene with the synthesized bimetallic precatalysts resulted in polymers with significantly higher isotacticity (up to 79% mmmm) in comparison to the stereoirregular polymers produced with previously reported C-5-symmetric monometallic analogues. The bimetallic precatalysts also display higher activity (up to 124 kg of poly(1-hexene) (mmol of Zr)(-1) h(-1)), in comparison to the monometallic analogues, and among the highest activities reported for nonmetallocene catalysts. The stereocontrol is consistent with a bimetallic mechanism involving remote steric interactions with the ligand sphere of the second metal center.

  DOI：

  10.1021/om500608j

文献信息

• Bimetallic Zirconium Amine Bis(phenolate) Polymerization Catalysts: Enhanced Activity and Tacticity Control for Polyolefin Synthesis
  作者：Madalyn R. Radlauer、Theodor Agapie

  DOI：10.1021/om500608j

  日期：2014.7.14

  Binucleating multidentate amine bis(phenolate) ligands with rigid terphenyl backbones were designed to support two zirconium centers locked in dose proximity. Polymerizations of propylene or 1-hexene with the synthesized bimetallic precatalysts resulted in polymers with significantly higher isotacticity (up to 79% mmmm) in comparison to the stereoirregular polymers produced with previously reported C-5-symmetric monometallic analogues. The bimetallic precatalysts also display higher activity (up to 124 kg of poly(1-hexene) (mmol of Zr)(-1) h(-1)), in comparison to the monometallic analogues, and among the highest activities reported for nonmetallocene catalysts. The stereocontrol is consistent with a bimetallic mechanism involving remote steric interactions with the ligand sphere of the second metal center.
• Highly Stereocontrolled Ring‐Opening Polymerization of Racemic Alkyl β‐Malolactonates Mediated by Yttrium [Amino‐alkoxy‐bis(phenolate)] Complexes
  作者：Cédric G. Jaffredo、Yulia Chapurina、Evgueni Kirillov、Jean‐François Carpentier、Sophie M. Guillaume

  DOI：10.1002/chem.201600223

  日期：2016.5.23

  resulting polyesters. ROP promoted by catalysts with halogen (Cl, Br)‐disubstituted ligands allowed the first reported synthesis of highly syndiotactic PMLARs (Pr ≥ 0.95); conversely, catalysts bearing bulky alkyl and aryl ortho‐substituted ligands proved largely ineffective. All polymers have been characterized by 1H and 13C1H} NMR spectroscopy, MALDI‐ToF mass spectrometry and DSC analyses. Statistical

  钇[氨基-烷氧基-双（酚盐）]酰胺基络合物已用于外消旋烷基β-丙二酸内酯（4-烷氧基羰基-2-氧杂环丁烷，rac - MLA R s）的开环聚合（ROP）。全部），苄基（Bz）或甲基（Me）侧酯官能团。金属辅助物中酚盐环上的邻位取代基的性质决定了ROP的立体控制，因此决定了所得聚酯的间规富集。ROP促进通过与卤素（氯，溴）催化剂二取代的配体允许高度间同立构PMLA的首次报道合成- [R S（P - [R ≥0.95）; 相反，带有庞大烷基和芳基邻位基团的催化剂事实证明，预取代的配体无效。所有聚合物均已通过1 H和13 C 1 H} NMR光谱，MALDI-ToF质谱和DSC分析进行了表征。统计和热分析使链端控制机制合理化。聚合的立体控制遵循rac ‐MLA Bz和rac ‐MLA All的ROP的马尔可夫一阶（Mk1）模型，而rac ‐MLA Me的ROP遵循导致了马尔可夫二阶类型（M