1,1,2,3,4,4-hexafluorobutane | 392-45-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: 1,1,2,3,4,4-hexafluorobutane
• 英文别名: 1H,2H,3H,4H-hexafluorobutane；1,1,2,3,4,4-hexafluoro-butane；1,1,2,3,4,4-Hexafluor-butan
• CAS: 392-45-0
• 化学式: C₄H₄F₆
• 分子量: 166.066
• InChiKey: INUAOGWHRYYQDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,1,2,3,4,4-hexafluorobutane 在 氢氧化钾 作用下， 生成 1,1,2,4,4-pentafluoro-but-2-ene
  参考文献：
  名称：

  Reactions of fluoro olefins

  摘要：

  DOI：

  10.1007/bf00907661
• 作为产物：
  描述：

  全氟丁二烯 在 palladium/alumina 氢气 作用下， 生成 1,1,2,3,4,4-hexafluorobutane
  参考文献：
  名称：

  Practical preparation of some potentially anesthetic fluoroalkanes: regiocontrolled introduction of hydrogen atoms

  摘要：

  Methods are described for the large-scale preparation of a number of fluoroalkanes, which have been tested for general anesthesia.

  DOI：

  10.1016/s0022-1139(00)80199-2

文献信息

• Addition of 1,2-dibromo-1-chlorotrifluoroethane to chlorotrifluoroethylene induced by uv-radiation. Synthesis of perfluoro-1,3-butadiene and perfluoro-1,3,5-hexatriene
  作者：V. Dědek、Z. Chvátal

  DOI：10.1016/s0022-1139(00)81263-4

  日期：1986.5

  5-hexadiene (VII), respectively. Photochemical reduction of butane III with 2-propanol resulted in a preferential reduction of CBr bonds, and from 2,3-dichloro-1,1,2,3,4,4-hexafluorobutane (IX) thus formed, esters of difluoroacetic acid were prepared by dehalogenation of IX and subsequent oxidation and esterification of the product. The photochemical reduction of hexane IV gave a mixture of 79% trichlorononafluorohexane

  1,2-二溴-1-氯三氟乙烷（II）与三氟氯乙烯（I）的光化学引发反应产生38％的1,4-二溴-2,3-二氯六氟丁烷（III）和19％的1,6-二溴-2,3除高级端粒外，还可以使用5-三氯九氟己烷（IV）。III和IV的脱卤作用分别用3-氯九氟-1,5-己二烯（VII）生成全氟-1,3-丁二烯（VI）和全氟-1,3,5-己三烯（VIII）。用2-丙醇对丁烷III进行光化学还原会优先还原CBr键，然后由由此形成的2,3-二氯-1,1,2,3,4,4-六氟丁烷（IX）生成二氟乙酸的酯通过IX脱卤并随后将产物氧化和酯化来制备酸。己烷IV的光化学还原得到79％三氯壬氟己烷XII和21％二氯壬氟己烷XIII的混合物。
• The fluorination of Butane over cobalt trifluoride
  作者：James Burdon、Saleh T. Ezmirly、Thomas N. Huckerby

  DOI：10.1016/s0022-1139(00)83070-5

  日期：1988.8

  The fluorination of butane over cobalt trifluoride has given a complex mixture of partially fluorinated compounds: 51 of these have been identified, comprising over 99% of the products. Most were polyfluorobutanes but 1-2% were polyfluoro-2-methylpropanes. The reaction has no synthetic utility. There was some selectivity in the fluorination: secondary C-H was converted into C-F more easily then primary

  丁烷在三氟化钴上的氟化产生了部分氟化化合物的复杂混合物：已鉴定出其中的51种化合物，占产品总量的99％以上。大部分是聚氟丁烷，但1-2％是聚氟-2-甲基丙烷。该反应没有合成效用。氟化具有一定的选择性：仲CH比初CH更容易转化为CF，双价和邻位氟减少了特定H的取代难度。氟化计算机仅部分成功，也许是因为氟化过程部分是通过简单的F取代H进行的，部分是通过烯烃进行的：该模型仅允许前者进行。
• Invasive fungal sinusitis in the acquired immunodeficiency syndrome
  作者：Scott M. Hunt、R. Christopher Miyamoto、Rebecca S. Cornelius、Thomas A. Tami

  DOI：10.1016/s0030-6665(00)80009-2

  日期：2000.4

  Invasive fungal sinusitis can present as either an indolent or fulminant process that primarily affects immunocompromised individuals. In this article, the clinical characteristics of four cases of invasive fungal sinusitis in patients with AIDS are analyzed and 22 additional previously reported cases in the literature are reviewed. In addition to HIV infection, other variables common to these cases include facial pain or headache out of proportion to clinical or radiographic findings, CD4 lymphocyte count less than 50 cells/mm(3), absolute neutrophil count less than 1,000 cells/mm(3), subtle radiographic evidence suggesting invasion and an indolent clinical course of the invasive infection. The most common pathogen detected was Aspergillus fumigatus. Maintaining a high index of suspicion, critically assessing these clinical findings, and prudently reviewing CT scans may facilitate early diagnosis and prompt intervention in these patients.
• DEDEK, V.;CHVATAL, Z., J. FLUOR. CHEM., 1986, 31, N 4, 363-379
  作者：DEDEK, V.、CHVATAL, Z.

  DOI：——

  日期：——
• Reactions of fluoro olefins
  作者：I. L. Knunyants、M. P. Krasuskaya、E. I. Mysov

  DOI：10.1007/bf00907661

  日期：1960.8