N,N-dicyclohexylhydroxylamine | 19627-68-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-dicyclohexylhydroxylamine
• 英文别名: N,N-Dicyclohexylhydroxylamin；dicyclohexylhydroxylamine；Dizyklohexylhydroxylamin；Cyclohexanamine, N-cyclohexyl-N-hydroxy-
• CAS: 19627-68-0
• 化学式: C₁₂H₂₃NO
• 分子量: 197.321
• InChiKey: QTZCGGNOVCUAQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-dicyclohexylhydroxylamine 、 benzyl prop-2-yn-1-yl carbonate 以 氯仿 、 2,2,2-三氟乙醇 为溶剂， 以40 %的产率得到(E)-N-(3-(((benzyloxy)carbonyl)oxy)prop-1-en-1-yl)-N-cyclohexylcyclohexanamine oxide
  参考文献：
  名称：

  [EN] ENAMINE N-OXIDES: SYNTHESIS AND APPLICATION TO HYPOXIA-RESPONSIVE PRODRUGS AND IMAGING AGENTS
  [FR] N-OXYDES D'ÉNAMINE : SYNTHÈSE ET APPLICATION À DES PROMÉDICAMENTS SENSIBLES À L'HYPOXIE ET AGENTS D'IMAGERIE

  摘要：

  Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that are suitable for diagnosis and the treatment of diseases and disorders characterized by, associate with or which exhibit tissue hypoxia, such as, for example, solid tumors. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds.

  公开号：

  WO2022204344A2
• 作为产物：
  描述：

  二环己胺 在 DMd 作用下， 以 丙酮 、 Petroleum ether 为溶剂， 以82.6%的产率得到N,N-dicyclohexylhydroxylamine
  参考文献：
  名称：

  Synthesis of hydroxylamines using dioxiranes

  摘要：

  该发明涉及一种从二级胺合成羟胺的方法。该方法使用二氧环丙烷类化合物，如二甲二氧环丙烷（DMD，相对稳定且易于合成）作为氧化剂。反应过程如下：##STR1## 该方法提供了一个简单的一步反应，收率高。它可以在丙酮溶液中进行，并且将氧原子从二甲二氧环丙烷转移到二级胺，将二氧环丙烷转化为溶剂丙酮，从而实现简单的后处理和纯化。该方法可以与各种类型的二级胺一起使用，包括脂肪族、芳香族、环状和杂环的二级胺，以制备相应种类的羟胺。

  公开号：

  US05001233A1

文献信息

• Stabilization of polymers with styrenated-p-cresols
  申请人：Gelbin Michael E.

  公开号：US20080207804A1

  公开（公告）日：2008-08-28

  Disclosed herein is a process for the preparation of a mixture of styrenated p-cresol species that is liquid at room temperature and has a viscosity of less than 40,000 cps at 25° C., wherein said process affords 2,6-distyrenated p-cresol assaying at 70% minimum by GC area percent, comprising reacting styrene with p-cresol at a molar ratio of 1.85 to 2.1:1, respectively, in the presence of an acid catalyst at elevated temperature, wherein said mixture comprises monostyrenated-p-cresol, distyrenated-p-cresol, and tristyrenated-p-cresol and exhibits an acid number of less than 0.1 mg KOH/gram.

  本文公开了一种制备液态且在室温下粘度小于40,000 cps的苯乙烯化p-甲基苯酚混合物的方法，其中该方法以GC面积百分比为最小值，提供了至少70%的2,6-二苯乙烯化p-甲基苯酚，包括在酸催化剂存在下，在升高的温度下将苯乙烯与p-甲基苯酚按摩尔比1.85至2.1:1反应，其中该混合物包括单苯乙烯化-p-甲基苯酚，二苯乙烯化-p-甲基苯酚和三苯乙烯化-p-甲基苯酚，并且具有小于0.1 mg KOH/克的酸值。
• Hindered amine light stabilizers comprising neoalkanediol phosphites
  申请人：Gelbin E. Michael

  公开号：US20060223918A1

  公开（公告）日：2006-10-05

  Disclosed herein are compounds of the structure: wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are independently selected alkyl groups, provided that R 1 is different from R 2 . The compounds are useful as stabilizers for thermoplastic resins.

  本文披露的化合物具有以下结构： 其中，R1、R2、R3、R4、R5和R6分别选择独立的烷基基团，但要求R1与R2不同。这些化合物可用作热塑性树脂的稳定剂。
• LIQUID STYRENATED PHENOLIC COMPOSITIONS AND PROCESSES FOR FORMING SAME
  申请人：Gelbin Michael E.

  公开号：US20090005478A1

  公开（公告）日：2009-01-01

  Disclosed herein are highly stable styrenated phenolic compositions that are liquids at room temperature, and polymer articles and lubricant compositions containing such styrenated phenolic compositions. Also disclosed are processes for forming such styrenated phenolic compositions, which processes afford distyrenated phenolics assaying at 70% minimum by total GC area, comprising reacting styrene with one or more phenolics, e.g., at least one of phenol, p-cresol and/or o-cresol, in the presence of an acid catalyst, preferably a sulfonic acid catalyst, at elevated temperature, wherein the resulting product mixture comprises one or more monostyrenated phenolics, one or more distyrenated phenolics, and one or more tristyrenated phenolics.

  本文披露了高度稳定的苯乙烯化酚类组合物，它们在室温下是液体，并且包含这种苯乙烯化酚类组合物的聚合物制品和润滑剂组合物。还披露了形成这种苯乙烯化酚类组合物的过程，该过程得到至少占总GC面积的70％的二苯乙烯化酚，包括在存在酸催化剂，优选为磺酸催化剂下，在升高的温度下，将苯乙烯与一个或多个酚反应，例如至少一个酚酚，对甲苯酚和/或邻甲酚，其中所得到的产物混合物包括一个或多个单苯乙烯化酚类，一个或多个二苯乙烯化酚类和一个或多个三苯乙烯化酚类。
• Process for preparing symmetrical and unsymmetrical N,N-dihydrocarbylhydroxylamines
  申请人：Scherhag Gunter

  公开号：US20070129574A1

  公开（公告）日：2007-06-07

  A process for preparing N,N-dihydrocarbylhydroxylamines of the general formula (I) where R 1 , R 2 , R 3 and R 4 are selected independently from among hydrogen, aliphatic, cycloaliphatic, heteroaromatic and aromatic radicals, or R 1 and R 2 and/or R 3 and R 4 are joined to form a ring, and not more than one radical among R 1 , R 2 , R 3 and R 4 is hydrogen, which comprises the steps a) reaction of hydroxylamine H 2 NOH or a salt of hydroxylamine with a compound of the general formula (II) or (III) where R 1 , R 2 , R 3 and R 4 are as defined in formula (I), b) hydrogenation of the compound formed in step a) in the presence of a catalyst, c) further reaction of the compound formed in step b) with a compound of the general formula (II) or (III) and hydrogenation of the reaction mixture in the presence of a catalyst and d), if appropriate, reaction of the salt of the dihydrocarbylhydroxylamine formed in step c) with a base.

  一种制备通式（I）的N，N-二烷基羟胺的方法，其中R1、R2、R3和R4独立选择自氢、脂肪、环脂肪、杂环芳香和芳香基团，或者R1和R2和/或R3和R4结合形成环，且R1、R2、R3和R4中不超过一个基团为氢，包括以下步骤：a）羟胺H2NOH或羟胺盐与通式（II）或（III）的化合物反应，其中R1、R2、R3和R4如通式（I）所定义，b）在催化剂存在下氢化步骤a）中形成的化合物，c）进一步反应步骤b）中形成的化合物与通式（II）或（III）的化合物并在催化剂存在下氢化反应混合物，以及d）如适当，在步骤c）中形成的二烷基羟胺盐与碱反应。
• PROCESS AND CATALYST SYSTEM FOR POLYDIENE PRODUCTION
  申请人：Luo Steven

  公开号：US20100216956A1

  公开（公告）日：2010-08-26

  Compositions and polydiene production processes involving catalyst systems comprising at least one lanthanide-containing compound, at least one alkylating agent, at least one halogen source, and at least one N,N-dihydrocarbylhydroxylamine.

  涉及至少包含一种镧系元素化合物、至少一种烷基化剂、至少一种卤素源和至少一种N，N-二烃基羟胺的催化剂体系的组合物和聚二烯生产过程。