5-(4-甲氧基苯基)吡啶-3-甲酰胺 | 198345-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 5-(4-甲氧基苯基)吡啶-3-甲酰胺
• 中文别名: 5-(4-甲氧苯基)烟酰胺
• 英文名称: 5-(4-Methoxyphenyl)pyridine-3-carboxamide
• 英文别名: 5-(4-Methoxyphenyl)nicotinamide
• CAS: 198345-91-4
• 化学式: C₁₃H₁₂N₂O₂
• 分子量: 228.25
• InChiKey: OFYGSCMHWJTHQF-UHFFFAOYSA-N

物化性质

• 沸点：
  434.2±40.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  65.2
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为产物：
  描述：

  5-溴烟酸 、 bromozinc(1+),methoxybenzene 在 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 三(2-呋喃基)膦 、 Rink-MBHA amide resin 、 三氟乙酸 作用下， 生成 5-(4-甲氧基苯基)吡啶-3-甲酰胺
  参考文献：
  名称：

  Multiple Cross-Coupling Reactions of Aryl and Benzylic Zinc Halides with Aryl Halides and Triflates in Solid-Phase Synthesis of Polyfunctional Aromatics

  摘要：

  使用 Rink 或 Wang 树脂，芳基和苄基溴化锌在固相上进行高效的 Pd(0)- 催化交叉偶联反应。通过与多元偶联试剂 2 和 3 发生交叉偶联反应，可以在固相上连续进行两个碳-碳键形成反应。

  DOI：

  10.1055/s-1997-1529

文献信息

• Aryl substituted pyridines and the use thereof
  申请人：Euro-Celtique S.A.

  公开号：US20030055088A1

  公开（公告）日：2003-03-20

  This invention relates aryl substituted pyridines of Formula I: 1 or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R 1 -R 4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

  本发明涉及公式I的芳基取代吡啶化合物：1或其药学上可接受的盐、前药或溶剂化物，其中Ar和R1-R4在规范中设置。本发明还涉及使用公式I的化合物治疗全局和局部缺血后的神经损伤，治疗或预防神经退行性疾病，如肌萎缩性侧索硬化症（ALS），以及治疗、预防或缓解急性或慢性疼痛，作为抗耳鸣剂，抗癫痫药物和抗躁狂抑郁药物，局部麻醉剂，抗心律失常药物以及治疗或预防糖尿病神经病变的用途。
• ARYL SUBSTITUTED PYRIDINECARBOXAMIDES AND THEIR USE AS SODIUM CHANNEL BLOCKERS
  申请人：Euro-Celtique S.A.

  公开号：EP1432419A1

  公开（公告）日：2004-06-30
• Aryl Substituted Pyridines and the Use Thereof
  申请人：SHAO Bin

  公开号：US20100048626A1

  公开（公告）日：2010-02-25

  This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R 1 -R 4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
• US7105549B2
  申请人：——

  公开号：US7105549B2

  公开（公告）日：2006-09-12
• US7579367B2
  申请人：——

  公开号：US7579367B2

  公开（公告）日：2009-08-25