N-benzyl-2-(furan-2-yl)-2-hydroxyacetamide | 887642-38-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-2-(furan-2-yl)-2-hydroxyacetamide
• CAS: 887642-38-8
• 化学式: C₁₃H₁₃NO₃
• 分子量: 231.251
• InChiKey: WEIRXMBIAFYIRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  62.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  糠醛 、 苄异腈 在 硼酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以65%的产率得到N-benzyl-2-(furan-2-yl)-2-hydroxyacetamide
  参考文献：
  名称：

  An efficient boric acid-mediated preparation of α-hydroxyamides

  摘要：

  An efficient methodology for the preparation of alpha-hydroxyamides via boric acid-mediated addition of isonitriles onto aldehydes has been developed. The reaction of isonitriles with alpha-boronobenzaldehyde takes place under intramolecular catalysis conditions to provide functionalized benzoxaboroles. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.12.008

文献信息

• An efficient boric acid-mediated preparation of α-hydroxyamides
  作者：J. Sravan Kumar、Subash C. Jonnalagadda、Venkatram R. Mereddy

  DOI：10.1016/j.tetlet.2009.12.008

  日期：2010.2

  An efficient methodology for the preparation of alpha-hydroxyamides via boric acid-mediated addition of isonitriles onto aldehydes has been developed. The reaction of isonitriles with alpha-boronobenzaldehyde takes place under intramolecular catalysis conditions to provide functionalized benzoxaboroles. (c) 2009 Elsevier Ltd. All rights reserved.