3,3'-(2-(4-tert-butylphenyl)ethene-1,1-diyl)dioxazolidin-2-one | 1085526-72-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3'-(2-(4-tert-butylphenyl)ethene-1,1-diyl)dioxazolidin-2-one
• 英文别名: 3-[2-(4-Tert-butylphenyl)-1-(2-oxo-1,3-oxazolidin-3-yl)ethenyl]-1,3-oxazolidin-2-one
• CAS: 1085526-72-2
• 化学式: C₁₈H₂₂N₂O₄
• 分子量: 330.384
• InChiKey: FAVDTQGXZUTZMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-唑烷酮 、 3-[(4-tert-butylphenyl)ethynyl]-1,3-oxazolidin-2-one 在 potassium phosphate 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以59%的产率得到3,3'-(2-(4-tert-butylphenyl)ethene-1,1-diyl)dioxazolidin-2-one
  参考文献：
  名称：

  Irregularities in the Effect of Potassium Phosphate in Ynamide Synthesis

  摘要：

  The yields of ynamides using Hsung's second generation protocol depend substantially on the quality of K3PO4. of K3PO4 from different suppliers were investigated by various techniques, revealing that the use Of pure and anhydrous K3PO4 provides higher ynamide yields in comparison to samples contaminated with hydrates (K3PO4 center dot 1.5H(2)O and K3PO4 center dot 7H(2)O). With high quality K3PO4, a number of ynamides were synthesized in yields of 52-91%. In addition. we report that ynamides can undergo regioselective hydroamination with carbamates.

  DOI：

  10.1021/jo801935b

文献信息

• Irregularities in the Effect of Potassium Phosphate in Ynamide Synthesis
  作者：Karin Dooleweerdt、Henrik Birkedal、Thomas Ruhland、Troels Skrydstrup

  DOI：10.1021/jo801935b

  日期：2008.12.5

  The yields of ynamides using Hsung's second generation protocol depend substantially on the quality of K3PO4. of K3PO4 from different suppliers were investigated by various techniques, revealing that the use Of pure and anhydrous K3PO4 provides higher ynamide yields in comparison to samples contaminated with hydrates (K3PO4 center dot 1.5H(2)O and K3PO4 center dot 7H(2)O). With high quality K3PO4, a number of ynamides were synthesized in yields of 52-91%. In addition. we report that ynamides can undergo regioselective hydroamination with carbamates.