benzylidene-2,2-bis(oxymethyl)propionic anhydride | 352708-07-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: benzylidene-2,2-bis(oxymethyl)propionic anhydride
• 英文别名: (5-Methyl-2-phenyl-1,3-dioxane-5-carbonyl) 5-methyl-2-phenyl-1,3-dioxane-5-carboxylate
• CAS: 352708-07-7
• 化学式: C₂₄H₂₆O₇
• 分子量: 426.466
• InChiKey: XPKZDFRVNAZHPT-UHFFFAOYSA-N

物化性质

• 熔点：
  151-153 °C(Solv: hexane (110-54-3))
• 沸点：
  572.2±50.0 °C(Predicted)
• 密度：
  1.219±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  benzylidene-2,2-bis(oxymethyl)propionic anhydride 在 palladium on activated charcoal 吡啶 、 4-二甲氨基吡啶 、 氢气 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and Self-Assembly of Supramolecular Dendritic “Bow-Ties”:  Effect of Peripheral Functionality on Association Constants

  摘要：

  Self-assembled polyester dendritic bow-ties with various peripheral groups were prepared, and their association constants were measured by H-1 NMR in CDCl3. The two complementary dendrons were prepared by attachment of either a bis(adamantylurea) or a glycinylurea to the focal point of the dendron. The parent self-assembled system with benzylidene acetals on one periphery and isopropylidene acetals on the other had an association constant of 520 M-1. Upon deprotection of one dendron, the association constant is increased by more than an order of magnitude as the solubility of the hydroxyl-terminated dendron in CDCl3 is decreased. In contrast, attachment of tri(ethylene oxide) units to the periphery of one dendron lowers the association constant by almost an order of magnitude. The causes of these relatively large changes in complex strength are discussed in terms of solubility, steric effects, competitive hydrogen bonding, and the structure of the dendritic scaffold.

  DOI：

  10.1021/jo035329s
• 作为产物：
  描述：

  亚苄基-2,2-双(氧基甲基)丙酸 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以88%的产率得到benzylidene-2,2-bis(oxymethyl)propionic anhydride
  参考文献：
  名称：

  The first peripherally masked thiol dendrimers: a facile and highly efficient functionalization strategy of polyester dendrimers via one-pot xanthate deprotection/thiol–acrylate Michael addition reactions

  摘要：

  我们提出了第一种黄羧酸酯表面功能性树状聚合物，可以快速进行一锅法去保护生成硫醇，然后进行丙烯酸酯迈克尔加成。

  DOI：

  10.1039/c3cc49704f

文献信息

• Synthesis, purification, and characterization of “perfect” star polymers via “Click” coupling
  作者：Yejia Li、Boyu Zhang、Jessica N. Hoskins、Scott M. Grayson

  DOI：10.1002/pola.25864

  日期：2012.3.15

  (I)‐catalyzed azide‐alkyne cycloaddition “click” reaction was successfully applied to prepare well‐defined 3, 6, and 12‐arms polystyrene and polyethylene glycol stars. This study focused particularly on making “perfect” star polymers with an exact number of arms, as well as developing techniques for their purification. Various methods of characterization confirmed the star polymers high purity, and the structural

  铜（I）催化的叠氮化物-炔烃环加成“点击”反应已成功用于制备定义明确的3臂，6臂和12臂聚苯乙烯和聚乙二醇星。这项研究特别关注于制造具有精确臂数的“完美”星形聚合物，以及开发其纯化技术。各种表征方法证实了星形聚合物的高纯度，以及生成的星形聚合物的结构均匀性。尤其是，基质辅助激光解吸电离飞行时间质谱分析揭示了线性聚合物前体上端基的定量转化，并证实了它们与树状核的定量偶联，得到了具有精确臂数的星形聚合物。b- PEG星形聚合物。©2011 Wiley Periodicals，Inc. J Polym Sci A部分：Polym Chem，2012年
• Designing Macromolecules for Therapeutic Applications:  Polyester DendrimerPoly(ethylene oxide) “Bow-Tie” Hybrids with Tunable Molecular Weight and Architecture
  作者：Elizabeth R. Gillies、Jean M. J. Fréchet

  DOI：10.1021/ja028100n

  日期：2002.11.1

  of the dendrons and the mass of the poly(ethylene oxide) chains, the molecular weight, architecture, and drug loading can be readily controlled. The "bow-tie" shaped dendritic scaffold was synthesized using both convergent and divergent methods, with orthogonal protecting groups on the periphery of the two dendrons. Poly(ethylene oxide) was then attached to the periphery of one dendron using an efficient

  描述了用于药物递送和相关治疗应用的新型聚酯树枝状聚合物、聚（环氧乙烷）杂化系统的设计和制备。这些系统由两个共价连接的聚酯树突组成，其中一个树突提供多种功能性手柄用于连接治疗活性部分，而另一个用于连接增溶聚（环氧乙烷）链。通过改变树枝的生成和聚（环氧乙烷）链的质量，可以很容易地控制分子量、结构和载药量。使用会聚和发散方法合成“领结”形树突支架，在两个树突的外围具有正交保护基团。然后使用有效的偶联程序将聚（环氧乙烷）连接到一个树突的外围。制备了一个包含 8 个分子量范围从约 20 kDa 到 160 kDa 的载体的小型文库，并通过各种技术对其进行了表征，证实了它们的明确结构。
• A New Approach to Heterofunctionalized Dendrimers:  A Versatile Triallyl Chloride Core
  作者：Scott M. Grayson、Jean M. J. Fréchet

  DOI：10.1021/ol0262993

  日期：2002.9.1

  A reactive triallyl chloride moiety was prepared as a suitable core for aliphatic polyether dendrons. In addition to allowing access to fourth generation dendrimers, this core contains three alkene functionalities that can be modified after dendrimer formation and used for further dendritic growth.

  制备反应性三烯丙基氯化物部分作为脂族聚醚树突的合适核。除了允许使用第四代树枝状大分子外，该核还包含三个烯烃官能团，可以在树枝状大分子形成后进行修饰，并用于进一步的树枝状生长。
• PROCESS FOR THE PREPARATION OF TEMSIROLIMUS AND ITS INTERMEDIATES
  申请人：Gupta Nitin

  公开号：US20110184167A1

  公开（公告）日：2011-07-28

  Novel intermediates, process for their preparation and their use in the preparation of therapeutically effective antineoplastic agents, in particular Temsirolimus of formula (I).

  新型中间体，其制备方法及其在制备具有治疗效果的抗肿瘤药物中的应用，特别是化学式（I）的坦索利莫司。
• [EN] POLYDENDRONS<br/>[FR] POLYDENDRONS
  申请人：UNIV LIVERPOOL

  公开号：WO2014199174A1

  公开（公告）日：2014-12-18

  A method of preparing a non-gelled branched vinyl polymer scaffold carrying dendrons, comprising the living or controlled polymerization of a monofunctional vinyl monomer and a difunctional vinyl monomer, using a dendron initiator and at least one further initiator.

  一种制备携带树枝状分子的非凝胶化支化乙烯聚合物支架的方法，包括对单官能乙烯单体和双官能乙烯单体进行活性或受控聚合，使用树枝状引发剂和至少一种进一步引发剂。