5,5'-((2,4-dichlorophenyl)methylene)bis(4-hydroxythiazole-2(3H)-one) | 1009814-36-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5,5'-((2,4-dichlorophenyl)methylene)bis(4-hydroxythiazole-2(3H)-one)
• 英文别名: 5-[(2,4-dichlorophenyl)-(4-hydroxy-2-oxo-3H-1,3-thiazol-5-yl)methyl]-4-hydroxy-3H-1,3-thiazol-2-one
• CAS: 1009814-36-1
• 化学式: C₁₃H₈Cl₂N₂O₄S₂
• 分子量: 391.256
• InChiKey: OOJODNICJIQTGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  149
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,4-噻唑烷二酮 、 2,4-二氯苯甲醛 在 copper nanoparticles subst. tetrazolium acetic acid 作用下， 以82%的产率得到5,5'-((2,4-dichlorophenyl)methylene)bis(4-hydroxythiazole-2(3H)-one)
  参考文献：
  名称：

  Copper nanoparticles in an ionic liquid: an efficient catalyst for the synthesis of bis-(4-hydroxy-2-oxothiazolyl)methanes

  摘要：

  Copper nanoparticles were synthesized and characterized by TEM, XRD and UV-vis techniques. The copper nanoparticles in an ionic liquid were employed as a recyclable catalyst for the synthesis of bis-(4-hydroxy-2-oxothiazolyl)methanes in excellent yields and in short reaction times. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.106

文献信息

• Effective preparation of 5,5’-(arylmethylene)bis(4-hydroxythiazole-2(3 H )-one) in an aqueous fluoroalcohol solvent system under ultrasound irradiation at room temperature
  作者：Mohammad Reza Poor Heravi、Mozhdeh Naghilou

  DOI：10.1016/j.cclet.2017.01.015

  日期：2017.5

  Abstract A green and convenient approach for the synthesis of a series of 5,5'-(arylmethylene)bis(4-hydroxythiazole-2(3H)-one) by the reaction of aryl aldehydes, monochloroacetic acid and ammonium thiocyanate in water/trifluoroethanol(TFE) (1:1) under ultrasound irradiation at room temperature is described. This method provides several advantages such as environmental friendliness, shorter time, excellent

  摘要通过芳醛，一氯乙酸和硫氰酸铵在水/三氟乙醇中的反应，合成一系列5,5'-（芳基亚甲基）双（4-羟基噻唑-2（3H）-一）的绿色简便方法描述了在室温下在超声辐射下的（TFE）（1：1）。该方法具有许多优点，例如环境友好，时间短，产率高以及后处理程序简单。
• Copper nanoparticles in an ionic liquid: an efficient catalyst for the synthesis of bis-(4-hydroxy-2-oxothiazolyl)methanes
  作者：Prashant Singh、Anju Katyal、Rashmi Kalra、Ramesh Chandra

  DOI：10.1016/j.tetlet.2007.11.106

  日期：2008.1

  Copper nanoparticles were synthesized and characterized by TEM, XRD and UV-vis techniques. The copper nanoparticles in an ionic liquid were employed as a recyclable catalyst for the synthesis of bis-(4-hydroxy-2-oxothiazolyl)methanes in excellent yields and in short reaction times. (c) 2007 Elsevier Ltd. All rights reserved.