6,7-dihydropyrido[3,2,1-ij]quinazoline-1,3 (2H,5H)-dione | 369594-22-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 6,7-dihydropyrido[3,2,1-ij]quinazoline-1,3 (2H,5H)-dione
• 英文别名: 6,7-Dihydro-1H,5H-pyrido[3,2,1-ij]quinazoline-1,3(2H)-dione；6,7-dihydropyrido[3,2,1-ij]quinazoline-1,3(2H,5H)-dione；1,3-diazatricyclo[7.3.1.05,13]trideca-5,7,9(13)-triene-2,4-dione
• CAS: 369594-22-9
• 化学式: C₁₁H₁₀N₂O₂
• 分子量: 202.213
• InChiKey: CADPOXHILVFCIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6,7-dihydropyrido[3,2,1-ij]quinazoline-1,3 (2H,5H)-dione 以11%的产率得到2-{3-[(S)-2-oxo-3-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)-oxazolidin-5-yl]-propyl}-6,7-dihydro-5H-pyrido[3,2,1-ij]quinazoline-1,3-dione
  参考文献：
  名称：

  QUINAZOLINE-2,4-DIONE DERIVATIVES

  摘要：

  该发明涉及式(I)的抗菌化合物，其中R1为H、卤素、(C1-C3)烷基或(C1-C3)氧烷；R2为H、卤素、(C1-C3)烷基、(C1-C3)氧烷或吡咯烷-1-基；R3为H、卤素、(C1-C3)烷基、(C1-C3)氧烷、乙烯基或2-甲氧羰基乙烯基，或R2和R3与携带它们的两个碳原子一起形成苯环；R4为H、卤素、(C1-C3)烷基或(C1-C3)氧烷；R5为H、(C1-C3)烷基或环丙基，或R4和R5一起形成一个—CH2CH2CH2—基团；A为二价基团—CH2—、—CH2CH2—、#—CH(OH)CH2—*、#—CH2N(R6)—*和—CH2NHCH2—，其中#表示可选择取代的(喹唑啉-2,4-二酮-3-基)甲基残基的连接点，*表示取代的(噁唑烷酮-4-基)甲基残基的连接点；R6为H或乙酰基；Y为CH或N；Q为O或S；以及这类化合物的盐。

  公开号：

  US20140171425A1

文献信息

• Tricyclic quinazolinediones
  申请人：——

  公开号：US20030105118A1

  公开（公告）日：2003-06-05

  A compound of the formula (1): 1 wherein —X 1 —X 2 — is a group of the formula: —C(═O)—N(R 7 )— or —C(R 8 )═N— (in which R 7 is hydrogen, substituted or unsubstituted alkyl, etc.; and R 8 is halogen, etc.); R 1 , R 2 and R 3 are independently hydrogen, substituted or unsubstituted alkyl, etc.; and R 4 is substituted or unsubstituted alkylene, or a prodrug thereof, or a pharmaceutically acceptable salt of the same, which exhibits an inhibitory activity of poly(ADP-ribose)polymerase (PARP) and is useful as remedies for diseases caused by the accelerated PARP activity such as brain ischemic disorders.

  式（1）的化合物：其中—X1—X2—是以下式的基团：—C(═O)—N(R7)—或—C(R8)═N—（其中R7为氢、取代或未取代的烷基等；R8为卤素等）；R1、R2和R3独立地为氢、取代或未取代的烷基等；R4为取代或未取代的亚烷基，或其前药，或其药用可接受的盐，该化合物具有对多聚(ADP-核糖)聚合酶（PARP）的抑制活性，并可用作用于由加速的PARP活性引起的疾病的药物，如脑缺血性疾病。
• Quinazoline-2,4-dione derivatives
  申请人：Hubschwerlen Christian

  公开号：US08916573B2

  公开（公告）日：2014-12-23

  The invention relates to antibacterial compounds of formula (I), wherein R1 is H, halogen, (C1-C3)alkyl or (C1-C3)alkoxy; R2 is H, halogen, (C1-C3)alkyl, (C1-C3)alkoxy or pyrrolidin-1-yl; R3 is H, halogen, (C1-C3)alkyl, (C1-C3)alkoxy, vinyl or 2-methoxycarbonyvinyl or R2 and R3 together with the two carbon atoms which bear them form a phenyl ring; R4 is H, halogen, (C1-C3)alkyl or (C1-C3)alkoxy; and R5 is H, (C1-C3)alkyl or cyclopropyl, or R4 and R5form together a —CH2CH2CH2— group; A is the divalent group —CH2—, —CH2CH2—, #—CH(OH)CH2—*, #—CH2N(R6)—* and —CH2NHCH2—, wherein # indicates the point of attachment to the optionally substituted (quinazoline-2,4-dione-3-yl)methyl residue and * represents the point of attachment to the substituted (oxazolidinon-4-yl)methyl residue; R6 is H or acetyl; Y is CH or N; and Q is O or S; and salts of such compounds.

  本发明涉及式(I)的抗菌化合物，其中R1为H、卤素、(C1-C3)烷基或(C1-C3)烷氧基；R2为H、卤素、(C1-C3)烷基、(C1-C3)烷氧基或吡咯烷-1-基；R3为H、卤素、(C1-C3)烷基、(C1-C3)烷氧基、乙烯基或2-甲氧羰基乙烯基，或R2和R3与它们所带的两个碳原子形成苯环；R4为H、卤素、(C1-C3)烷基或(C1-C3)烷氧基；R5为H、(C1-C3)烷基或环丙基，或R4和R5共同形成—CH2CH2CH2—基团；A为二价基团—CH2—、—CH2CH2—、#—CH(OH)CH2—*、#—CH2N(R6)—*和—CH2NHCH2—，其中#表示连接到可选取代的(喹唑啉-2,4-二酮-3-基)甲基残基的连接点，*表示连接到取代的(噁唑烷-4-基)甲基残基的连接点；R6为H或乙酰基；Y为CH或N；Q为O或S；以及这些化合物的盐。
• TRICYCLIC QUINAZOLINEDIONES
  申请人：Sumitomo Pharmaceuticals Company, Limited

  公开号：EP1288216A1

  公开（公告）日：2003-03-05

  A compound of the formula (1): wherein -X1-X2- is a group of the formula: -C(=O)-N(R7)- or -C(R8)=N- (in which R7 is hydrogen, substituted or unsubstituted alkyl, etc.; and R8 is halogen, etc.); R1, R2 and R3 are independently hydrogen, substituted or unsubstituted alkyl, etc.; and R4 is substituted or unsubstituted alkylene, or a prodrug thereof, or a pharmaceutically acceptable salt of the same, which exhibits an inhibitory activity of poly(ADP-ribose)-polymerase (PARP) and is useful as remedies for diseases caused by the accelerated PARP activity such as brain ischemic disorders.

  式（1）的化合物： 其中 -X1-X2- 是式中的基团：-C(＝O)-N(R7)-或-C(R8)＝N-(其中 R7 是氢、取代或未取代的烷基等；R8 是卤素等)； R1、R2 和 R3 独立地是氢、取代或未取代的烷基等。R1、R2 和 R3 独立地是氢、取代或未取代的烷基等；R4 是取代或未取代的亚烷基，或其原药，或其药学上可接受的盐，对多（ADP-核糖）聚合酶（PARP）具有抑制活性，可用于治疗因 PARP 活性加速而引起的疾病，如脑缺血性疾病。
• US8916573B2
  申请人：——

  公开号：US8916573B2

  公开（公告）日：2014-12-23
• QUINAZOLINE-2,4-DIONE DERIVATIVES
  申请人：Hubschwerlen Christian

  公开号：US20140171425A1

  公开（公告）日：2014-06-19

  The invention relates to antibacterial compounds of formula (I), wherein R 1 is H, halogen, (C 1 -C 3 )alkyl or (C 1 -C 3 )alkoxy; R 2 is H, halogen, (C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy or pyrrolidin-1-yl; R 3 is H, halogen, (C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy, vinyl or 2-methoxycarbonyvinyl or R 2 and R 3 together with the two carbon atoms which bear them form a phenyl ring; R 4 is H, halogen, (C 1 -C 3 )alkyl or (C 1 -C 3 )alkoxy; and R 5 is H, (C 1 -C 3 )alkyl or cyclopropyl, or R 4 and R 5 form together a —CH 2 CH 2 CH 2 — group; A is the divalent group —CH 2 —, —CH 2 CH 2 —, #—CH(OH)CH 2 —*, #—CH 2 N(R 6 )—* and —CH 2 NHCH 2 —, wherein # indicates the point of attachment to the optionally substituted (quinazoline-2,4-dione-3-yl)methyl residue and * represents the point of attachment to the substituted (oxazolidinon-4-yl)methyl residue; R 6 is H or acetyl; Y is CH or N; and Q is O or S; and salts of such compounds.

  该发明涉及式(I)的抗菌化合物，其中R1为H、卤素、(C1-C3)烷基或(C1-C3)氧烷；R2为H、卤素、(C1-C3)烷基、(C1-C3)氧烷或吡咯烷-1-基；R3为H、卤素、(C1-C3)烷基、(C1-C3)氧烷、乙烯基或2-甲氧羰基乙烯基，或R2和R3与携带它们的两个碳原子一起形成苯环；R4为H、卤素、(C1-C3)烷基或(C1-C3)氧烷；R5为H、(C1-C3)烷基或环丙基，或R4和R5一起形成一个—CH2CH2CH2—基团；A为二价基团—CH2—、—CH2CH2—、#—CH(OH)CH2—*、#—CH2N(R6)—*和—CH2NHCH2—，其中#表示可选择取代的(喹唑啉-2,4-二酮-3-基)甲基残基的连接点，*表示取代的(噁唑烷酮-4-基)甲基残基的连接点；R6为H或乙酰基；Y为CH或N；Q为O或S；以及这类化合物的盐。