tert-butyl (3-bromo-2-fluorophenyl)carbamate | 848440-23-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl (3-bromo-2-fluorophenyl)carbamate
• 英文别名: tert-butoxy-N-(3-bromo-2-fluorophenyl)carboxamide；(3-bromo-2-fluorophenyl)carbamic acid tert-butyl ester；tert-butyl N-(3-bromo-2-fluorophenyl)carbamate
• CAS: 848440-23-3
• 化学式: C₁₁H₁₃BrFNO₂
• 分子量: 290.132
• InChiKey: JUOBTFMEQFYGLH-UHFFFAOYSA-N

物化性质

• 沸点：
  271.2±30.0 °C(Predicted)
• 密度：
  1.459±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl (3-bromo-2-fluorophenyl)carbamate 在 磺酰氯 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 7-溴-2-氯苯并噻唑
  参考文献：
  名称：

  Small molecules enhance functional O-mannosylation of Alpha-dystroglycan

  摘要：

  Alpha-dystroglycan (alpha-DG), a highly glycosylated receptor for extracellular matrix proteins, plays a critical role in many biological processes. Hypoglycosylation of alpha-DG results in various types of muscular dystrophies and is also highly associated with progression of majority of cancers. Currently, there are no effective treatments for those devastating diseases. Enhancing functional O-mannosyl glycans (FOG) of alpha-DG on the cell surfaces is a potential approach to address this unmet challenge. Based on the hypothesis that the cells can up-regulate FOG of alpha-DG in response to certain chemical stimuli, we developed a cell-based high-throughput screening (HTS) platform for searching chemical enhancers of FOG of alpha-DG from a large chemical library with 364,168 compounds. Sequential validation of the hits from a primary screening campaign and chemical works led to identification of a cluster of compounds that positively modulate FOG of alpha-DG on various cell surfaces including patient-derived myoblasts. These compounds enhance FOG of alpha-DG by almost ten folds, which provide us powerful tools for O-mannosylation studies and potential starting points for the development of drug to treat dystroglycanopathy. (c) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.11.011
• 作为产物：
  描述：

  3-溴-2-氟苯甲酸 、 叔丁醇 在 叠氮磷酸二苯酯 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 2.0h， 生成 tert-butyl (3-bromo-2-fluorophenyl)carbamate
  参考文献：
  名称：

  Small-compound enhancers for functional O-mannosylation of alpha-dystroglycan, and uses thereof

  摘要：

  本发明提供了一种可以增强蛋白质的O-甘露糖基化功能，包括α-骨骼肌糖蛋白的化合物。还提供了一种按照式I定义的化合物的制备方法。同时提供了使用这些化合物或其药用可接受的盐或前药来治疗和预防患有包括肌肉萎缩症和癌症在内的疾病的方法。

  公开号：

  US10221168B1

文献信息

• [EN] DIACYLGLYCEROL KINASE MODULATING COMPOUNDS<br/>[FR] COMPOSÉS MODULANT LA DIACYLGLYCÉROL KINASE
  申请人：CARNA BIOSCIENCES INC

  公开号：WO2021130638A1

  公开（公告）日：2021-07-01

  The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

  本公开提供了调节二酰基甘油激酶的化合物以及用于治疗癌症（包括实体瘤）和病毒感染（如HIV或乙型肝炎病毒感染）的药物组合物。这些化合物可以单独使用或与其他药物联合使用。
• [EN] TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS<br/>[FR] COMPOSÉS DE TRIAZOLOPYRIDINE EN TANT QU'INHIBITEURS DE KINASE PIM
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2012154274A1

  公开（公告）日：2012-11-15

  Compounds of Formula I: in which R1, R2, R3, R4 and R10 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.

  式I的化合物：其中R1、R2、R3、R4和R10的含义如规范中所述，在通过PIM-1和/或PIM-2和/或PIM-3激酶介导的疾病治疗中有用的受体酪氨酸激酶抑制剂。
• [EN] N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE N-(PHÉNYL SUBSTITUÉ)-SULFONAMIDE EN TANT QU'INHIBITEURS DE KINASE
  申请人：NERVIANO MEDICAL SCIENCES SRL

  公开号：WO2017220477A1

  公开（公告）日：2017-12-28

  The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

  这项发明涉及N-(取代苯基)-磺酰胺化合物，这些化合物作为蛋白激酶（例如PERK激酶）的抑制剂非常有用，因此可用于治疗细胞增殖异常（如癌症）或与激活的未折叠蛋白反应途径相关的疾病，如阿尔茨海默病。本发明还提供了制备这些化合物的方法、包含这些化合物的药物组合物、以及利用包含这些化合物的药物组合物治疗疾病的方法。
• [EN] QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS<br/>[FR] DERIVES DE QUINAZOLINE UTILISES COMME INHIBITEURS DE LA TYROSINE KINASE
  申请人：ASTRAZENECA AB

  公开号：WO2005026150A1

  公开（公告）日：2005-03-24

  The invention concerns quinazoline derivatives of the Formula (I); wherein each of R1, R2, W, X1, X2, Z, a and b are as defined in the description; processes for their preparation; pharmaceutical compositions containing them and their use in the manufacture of a medicament for providing an anti-proliferative effect. The quinazoline derivatives of Formula (I) are expected to be useful in the treatment of diseases such as certain cancers mediated by erbB receptor tyrosine kinases, particularly EGFR tyrosine kinase.

  该发明涉及配方（I）的喹唑啉衍生物；其中R1、R2、W、X1、X2、Z、a和b在描述中有定义；它们的制备方法；含有它们的药物组合物以及它们在制造用于提供抗增殖效果的药物的用途。配方（I）的喹唑啉衍生物预计在治疗某些由erbB受体酪氨酸激酶介导的癌症等疾病中具有用处，特别是EGFR酪氨酸激酶。
• [EN] FURANONE COMPOUNDS AS KINASE INHIBITORS<br/>[FR] COMPOSES DE FURANONE COMME INHIBITEURS DE KINASE
  申请人：ETERNITY BIOSCIENCE INC

  公开号：WO2014182873A1

  公开（公告）日：2014-11-13

  The present disclosure provides novel furanone compounds, or pharmaceutically acceptable salts, solvates or prodrugs thereof, as Raf kinase, especially BRAF kinase, inhibitors, which are useful therapeutic agents for treatment of Raf kinase related diseases or disorders, such as melanomas, cancers, and leukemia. The disclosure also provides methods and processes for preparing these novel furanone compounds, pharmaceutical compositions containing these furanone compounds, and methods of treatment using these furanone compounds.

  本公开提供了新颖的呋喃酮化合物，或其药用可接受的盐、溶剂合物或前药，作为Raf激酶，特别是BRAF激酶的抑制剂，这些抑制剂对于治疗与Raf激酶相关的疾病或疾病，如黑色素瘤、癌症和白血病是有效的治疗药物。该公开还提供了制备这些新颖呋喃酮化合物的方法和过程，含有这些呋喃酮化合物的药物组合物，以及使用这些呋喃酮化合物进行治疗的方法。