bis-(2-benzylamino-ethyl)-disulfide | 29824-06-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis-(2-benzylamino-ethyl)-disulfide
• 英文别名: Bis-(2-benzylamino-aethyl)-disulfid；2,2'-disulfanediylbis(N-benzylethanamine)；N-benzyl-2-[2-(benzylamino)ethyldisulfanyl]ethanamine
• CAS: 29824-06-4
• 化学式: C₁₈H₂₄N₂S₂
• 分子量: 332.534
• InChiKey: SKWRXHRHQALQOK-UHFFFAOYSA-N

物化性质

• 沸点：
  475.4±40.0 °C(Predicted)
• 密度：
  1.128±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  74.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N,N'-(2,2'-disulfanediylbis(ethane-2,1-diyl))dibenzamide 在 硼烷四氢呋喃络合物 作用下， 以10%的产率得到bis-(2-benzylamino-ethyl)-disulfide
  参考文献：
  名称：

  Discovery of new small molecules that influence neuroblast cell migration from the subventricular zone

  摘要：

  Using SVZ (subventricular zone) tissue explants from one-day-old mice, we investigated the activity of new amino aromatic disulfide analogues and polyazamacrocycles on the migration of SVZ cells (neuroblasts). We found that among the tested analogues, non-peptidic disulfide derivative 8 significantly decreases the migration of neuroblasts from SVZ cells, and antagonized the stimulating activity of disulfide cyclic peptide 1. Discovery of compounds 1 and 8 constitutes new chemical tools which could be used to understand the mechanism of neuroblast migration during neurogenesis and eventually to identify specific genes involved in the neurogenesis. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.112

文献信息

• Structure-activity relationships among di- and tetramine disulfides related to benextramine
  作者：M. Alvarez、R. Granados、D. Mauleon、G. Rosell、M. Salas、J. Salles、N. Valls

  DOI：10.1021/jm00390a011

  日期：1987.7

  The synthesis and irreversible alpha-blocking activity in the rat vas deferens of a series of tetra- and diamine disulfides 2-38, structural analogues of benextramine (BHC), are described. All compounds containing a central cystamine moiety displayed an irreversible alpha-adrenergic blockade at concentrations ranging from 10(-4) to 6 X 10(-6)M. Potency was increased in cystamines N,N'-disubstituted with 6-aminohexyl groups, especially when the outer nitrogen atoms bear arylalkyl substituents or are enclosed in a ring. However, N,N,N',N'-tetrasubstituted cystamines were poor blockers. Structural specificity in the outer portion of the tetramine disulfide is low, since many types of substituents gave rise to potent alpha-blockers. Even replacement of the outer amines with nonbasic ethers or amides was observed to maintain irreversible alpha-blockade.
• Dawson, Journal of the American Chemical Society, 1933, vol. 55, p. 2071
  作者：Dawson

  DOI：——

  日期：——
• Action of hydrogen sulfide on aminoalkanethiosulfuric acids (Bunte salts) to give di-, tri-, and tetrasulfides
  作者：Daniel L. Klayman、David Kenny、Richard B. Silverman、Joseph E. Tomaszewski、Robert J. Shine

  DOI：10.1021/jo00823a005

  日期：1971.12
• Kolesowa; Kissel, Zhurnal Obshchei Khimii, 1957, vol. 27, p. 1084;engl.Ausg.S.1168
  作者：Kolesowa、Kissel

  DOI：——

  日期：——
• ALVAREZ, M.;GRANADOS, R.;MAULEON, D.;ROSELL, G.;SALAS, M.;SALLES, J.;VALL+, J. MED. CHEM., 30,(1987) N 7, 1186-1193
  作者：ALVAREZ, M.、GRANADOS, R.、MAULEON, D.、ROSELL, G.、SALAS, M.、SALLES, J.、VALL+

  DOI：——

  日期：——