N-[(1S)-phenylethyl]ethane-1,2-diamine | 116949-14-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-[(1S)-phenylethyl]ethane-1,2-diamine
• 英文别名: (S)-N-(1-phenylethyl)ethane-1,2-diamine；S-mben；N-[(1S)-1-phenylethyl]ethane-1,2-diamine；N'-[(1S)-1-phenylethyl]ethane-1,2-diamine
• CAS: 116949-14-5
• 化学式: C₁₀H₁₆N₂
• 分子量: 164.25
• InChiKey: PPLYZPAMMOECNS-VIFPVBQESA-N

物化性质

• 沸点：
  263.6±15.0 °C(Predicted)
• 密度：
  0.974±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-[(1S)-phenylethyl]ethane-1,2-diamine 在 barium permanganate 、 4 A molecular sieve 、 溶剂黄146 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 21.0h， 生成 1-[(1S)-1-苯基乙基]咪唑
  参考文献：
  名称：

  New chiral imidazolinic derivatives

  摘要：

  Novel C-2 substituted 4,5-dihydroimidazoles and imidazoles bearing an N-linked stereogenic group were rapidly prepared from a chiral primary amine. Quaternization of these derivatives resulted in a range of scalemic room temperature ionic liquids. The ability of the imidazolium species to act as reaction medium and/or phase transfer catalyst was also assessed. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.01.014
• 作为产物：
  描述：

  (S)-(-)- α-甲基苄胺 、 2-氯乙胺 以 水 为溶剂， 反应 3.0h， 生成 N-[(1S)-phenylethyl]ethane-1,2-diamine
  参考文献：
  名称：

  New chiral imidazolinic derivatives

  摘要：

  Novel C-2 substituted 4,5-dihydroimidazoles and imidazoles bearing an N-linked stereogenic group were rapidly prepared from a chiral primary amine. Quaternization of these derivatives resulted in a range of scalemic room temperature ionic liquids. The ability of the imidazolium species to act as reaction medium and/or phase transfer catalyst was also assessed. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.01.014

文献信息

• Unprecedented 2D Homochiral Hybrid Lead‐Iodide Perovskite Thermochromic Ferroelectrics with Ferroelastic Switching
  作者：Yu‐Ling Zeng、Xue‐Qin Huang、Chao‐Ran Huang、Hua Zhang、Fang Wang、Zhong‐Xia Wang

  DOI：10.1002/anie.202102195

  日期：2021.5.3

  relationship. They both undergo 222F2‐type paraelectric–ferroelectric behavior at around 378 K coupled with clear ferroelastic domain “ON/OFF” switching. Besides, they exhibit an evident thermochromism with color change from orange–yellow to orange–red. To our knowledge, the discovery of integrated ferroelectricity, ferroelasticity, and reversible thermochromism in chiral perovskites is unprecedented

  手性钙钛矿已成为一类重要的材料，显示出有希望的光电和自旋电子应用。但是，关于手性钙钛矿铁电材料的报道很少。在这项工作中，我们成功地合成了同手性碘化钙钛矿型铁电体[（R）-N-（1-苯乙基）乙烷-1，2-二铵] PbI 4和[（S）-N-（1-苯乙基）乙烷-1,2-二胺鎓]碘化铅4通过引入甲基成母体（的有机阳离子ñ -benzylethane -1,2-二胺鎓）碘化铅4。振动圆二色性光谱确定手性镜像关系。他们俩都经历了222 F2型顺电-铁电行为在378 K左右，加上清晰的铁弹性域“ ON / OFF”切换。此外，它们还表现出明显的热致变色，其颜色从橙黄色变为橙红色。据我们所知，在手性钙钛矿中发现集成铁电，铁弹性和可逆热致变色是前所未有的。
• Conformation-control in planar metal complexes (Cu2+, Pd2+, Pt2+) of ethylenediamine derivatives with a chiral N-substituent and interpretation of CD spectra based on regional rule
  作者：Hiroshi Sakiyama、Hisashi Ōkawa、Naohide Matsumoto、Sigeo Kida、Ichiro Murase

  DOI：10.1016/s0020-1693(00)83121-7

  日期：1989.8

  Planar metal complexes (Cu2+, Pd2+, Pt2+) of N-substituted ethylenediamine, N-(R)-α-methylbenzyl}ethylenediamine (R-mben), N-(S)-α-methyl-benzyl}ethylenediamine (S-mben) and N-(L-menthyl)ethylenediamine (mten), have been prepared and their stereochemistry (configuration around the nitrogen and ethylene conformation) is examined in view of the vicinal effect of the chiral N-substituent. Each complex

  平面金属配合物（铜2+，钯2+，铂2+ N-取代的乙二胺），ñ - （[R）-α甲基苄基}乙二胺（ř -mben），ñ - （小号）-α甲基已经制备了-苄基}乙二胺（S- mben）和N-（L-薄荷基）乙二胺（mten），并考虑了手性N-的邻位作用，研究了它们的立体化学（围绕氮和乙烯构象的构型）。取代基。每个复合物在配体场带上显示出明显的圆二色性（CD）。本配合物及相关的铜（II）配合物的CD光谱与N-取代的（ř）-1,2-丙二胺可以根据区域规则（十六进制规则）进行合理解释。
• Triazole derivatives as tachykinin receptor antagonists
  申请人：Amegadzie Kudzovi Albert

  公开号：US20050239786A1

  公开（公告）日：2005-10-27

  This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C 1 -C 3 alkane-diyl; R 1 is phenyl, which is optionally substituted with one to three substitutents independently selected from the group consisting of halo, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R 4 is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)

  本申请涉及化合物I式或其药学上可接受的盐，其药物组合物以及其作为tachykinin受体NK-1亚型的抑制剂的用途，以及其制备过程和中间体。其中：D是C1-C3烷基二亚基；R1是苯基，可选地取代为一个至三个取代基，独立地选自卤素，C1-C4烷基，C1-C4烷氧基，氰基，二氟甲基，三氟甲基和三氟甲氧基的群；R4是从群 consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)中选择的基团。
• 10A-AZALIDE COMPOUND HAVING 4-MEMBERED RING STRUCTURE
  申请人：Sugimoto Tomohiro

  公开号：US20110152239A1

  公开（公告）日：2011-06-23

  The present invention relates to a process for preparing compositions of high concentrations of omega-3 fatty acids from krill. Furthermore, the invention relates to a composition comprising high concentrations of omega-3 fatty acids, and a lipid fraction from krill comprising high amounts of the fatty acids with chain length C14 and C 16.

  本发明涉及一种从磷虾制备高浓度ω-3脂肪酸组合物的方法。此外，本发明涉及一种包含高浓度ω-3脂肪酸的组合物，以及从磷虾中提取的含有链长为C14和C16的脂肪酸高含量的脂质分数。
• Synthesis of novel room temperature chiral ionic liquids: application as reaction media for the heck arylation of aza-endocyclic acrylates
  作者：Julio C. Pastre、Yves Génisson、Nathalie Saffon、Jany Dandurand、Carlos R. D. Correia

  DOI：10.1590/s0103-50532010000500009

  日期：——

  New achiral and chiral RTILs were prepared using novel and/or optimized synthetic routes. These new series of imidazolinium, imidazolium, pyridinium and nicotine-derived ionic liquids were fully characterized including differential scanning calorimetry (DSC) analysis. The performance of these achiral and chiral room temperature ionic liquids (RTILs) was demonstrated by means of the Heck arylation of endocyclic acrylates employing arenediazonium salts and aryl iodides. The Heck arylations performed in the presence of these ionic entities, either as a solvent or as an additive, were effective leading to complete conversion of the substrate and good to excellent yield of the Heck adduct. In spite of the good performances, no asymmetric induction was observed in any of the cases studied. Two new diastereoisomeric NHC-palladium complexes were prepared in good yields from a chiral imidazolium salt and their structure characterized by X-ray diffraction. Overall, the Heck arylations employing arenediazonium tetrafluoroborates in RTILs were more effective than the traditional protocols employing aryl iodides in terms of reactivity and yields.