2-fluoro-4-isopropylaniline | 87119-12-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-fluoro-4-isopropylaniline
• 英文别名: 2-fluoro-4-propan-2-ylaniline
• CAS: 87119-12-8
• 化学式: C₉H₁₂FN
• 分子量: 153.199
• InChiKey: UHLWQRYLMMKFRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  氯磺酰异氰酸酯 、 2-fluoro-4-isopropylaniline 、 2-溴乙醇 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以38 %的产率得到N-(2-fluoro-4-isopropylphenyl)-2-oxooxazolidine-3-sulfonamide
  参考文献：
  名称：

  [EN] PYRIDAZINONE DERIVATIVES USEFUL AS T CELL ACTIVATORS
  [FR] DÉRIVÉS DE PYRIDAZINONE UTILES EN TANT QU'ACTIVATEURS DE LYMPHOCYTES T

  摘要：

  Disclosed herein are oxime compounds having the structure of Formula (I'): or a pharmaceutically acceptable salt, solvate, hydrate, isomer, tautomer, racemate, or isotope thereof, wherein L1, L2, R1, R2, R3, R4, R7, n, and r are as defined herein. Pharmaceutical compositions comprising them, processes for preparing them and uses of them to treat or prevent diseases, disorders and conditions are also provided. The compounds are inhibitors of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ) and are useful in the treatment of diseases, disorders and conditions related to DGKα and / or DGKζ activity. In particular, the compounds are useful for treating viral infections and proliferative disorders, such as cancer.

  公开号：

  WO2023122778A1
• 作为产物：
  描述：

  2-fluoro-4-(prop-1-en-2-yl)aniline 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙酸乙酯 为溶剂， 以88 %的产率得到2-fluoro-4-isopropylaniline
  参考文献：
  名称：

  [EN] PYRIDAZINONE DERIVATIVES USEFUL AS T CELL ACTIVATORS
  [FR] DÉRIVÉS DE PYRIDAZINONE UTILES EN TANT QU'ACTIVATEURS DE LYMPHOCYTES T

  摘要：

  Disclosed herein are oxime compounds having the structure of Formula (I'): or a pharmaceutically acceptable salt, solvate, hydrate, isomer, tautomer, racemate, or isotope thereof, wherein L1, L2, R1, R2, R3, R4, R7, n, and r are as defined herein. Pharmaceutical compositions comprising them, processes for preparing them and uses of them to treat or prevent diseases, disorders and conditions are also provided. The compounds are inhibitors of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ) and are useful in the treatment of diseases, disorders and conditions related to DGKα and / or DGKζ activity. In particular, the compounds are useful for treating viral infections and proliferative disorders, such as cancer.

  公开号：

  WO2023122778A1

文献信息

• 4-Alkyl-2-haloaniline derivative and process and process for producing the same
  申请人：Nishizuka Toshio

  公开号：US20050143454A1

  公开（公告）日：2005-06-30

  The present invention relates to a compound of formula (1), wherein R 1 , R 2 , R 3 , n, and X are as defined in the specification, and a process for producing the same. This compound is useful as an intermediate for the synthesis of compounds useful as pharmaceuticals or agricultural chemicals.

  本发明涉及一种式（1）的化合物，其中R1、R2、R3、n和X如规范中所定义，并提供其生产方法。该化合物可用作合成对制药或农业化学品有用的化合物的中间体。
• UNSATURATED NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS
  申请人：ALLEN Jennifer R.

  公开号：US20110306587A1

  公开（公告）日：2011-12-15

  Unsaturated nitrogen heterocyclic compounds of formula (I): as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

  式(I)的不饱和氮杂环化合物，如本说明书中所定义的，含有它们的组合物以及制备这种化合物的方法。本文还提供了治疗可通过抑制PDE10治疗的疾病或疾病的方法，例如肥胖症，亨廷顿病，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症等。
• Azaquinazoline Inhibitors of Atypical Protein Kinase C
  申请人：Cancer Research Technology Limited

  公开号：US20160102094A1

  公开（公告）日：2016-04-14

  The present application provides a compound of formula (1) or a salt thereof, wherein R 7 , R 8 , R 9 , G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative diseases.

  本申请提供了一个公式（1）的化合物或其盐，其中R7、R8、R9、G和X的定义如本文所述。本申请进一步描述了包含这些化合物的组合物。公式（I）的化合物及其盐具有aPKC抑制活性，并可用于治疗增殖性疾病。
• Process for the selective alkylation of an aniline
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0079093A1

  公开（公告）日：1983-05-18

  An aniline is alkylated selectively at the nuclear position para to the amino group by reacting it with an alkylating agent, preferably an alkyl chloride, in the presence of at least 1.02 mole of an aluminium halide per mole of the aniline.

  在每摩尔苯胺至少含有 1.02 摩尔卤化铝的情况下，苯胺与烷化剂（最好是烷基氯化物）反应，选择性地在氨基对位的核位置烷基化。
• Ortho-alkylated aromatic amines via gamma alumina catalyst
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0334332A1

  公开（公告）日：1989-09-27

  This invention relates to a process for producing ring alkylated aromatic amines. In the process an aromatic amine is reacted with an olefin using gamma alumina as a catalyst. Under the conditions of the process the catalyst is extremely active and with amines that are capable of alkylation at the ortho and para positions, high selectivity to the ortho alkylated isomer can be achieved. The catalyst is also effective for producing unsymmetrical disubstituted alkyl aromatic amines, e.g., ethyl or propyl toluidine where one ortho position is substituted with a methyl group and the other substituted with an ethyl or propyl group.

  本发明涉及一种生产环烷基化芳香胺的工艺。在该工艺中，以γ氧化铝为催化剂，芳香胺与烯烃发生反应。在该工艺的条件下，催化剂的活性极高，对于能够在正位和对位发生烷基化反应的胺，可以实现对正位烷基化异构体的高选择性。 该催化剂对生产非对称二取代烷基芳香胺也很有效，例如，乙基或丙基甲苯胺，其中一个正位被甲基取代，另一个正位被乙基或丙基取代。