(2,3-Dichlorophenyl)-dimethoxyphosphorylmethanol | 1217702-69-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,3-Dichlorophenyl)-dimethoxyphosphorylmethanol
• 英文别名: (2,3-dichlorophenyl)-dimethoxyphosphorylmethanol
• CAS: 1217702-69-6
• 化学式: C₉H₁₁Cl₂O₄P
• 分子量: 285.064
• InChiKey: WHZOSLMHKHWVBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,3-二氯苯甲醛 、 亚磷酸二甲酯 在 guanidine supported magnetic Fe₃O₄ nanoparticle 作用下， 以 neat (no solvent) 为溶剂， 反应 1.5h， 以98%的产率得到(2,3-Dichlorophenyl)-dimethoxyphosphorylmethanol
  参考文献：
  名称：

  Synthesis, characterization and catalytic properties of magnetic nanoparticle supported guanidine in base catalyzed synthesis of α-hydroxyphosphonates and α-acetoxyphosphonates

  摘要：

  Magnetic nanoparticle Fe3O4-immobilized guanidine (MNPs-Guanidine) as a novel magnetically interphase nanocatalyst was synthesized and characterized. MNPs-Guanidine catalyzed the synthesis of alpha-hydroxyphosphonates from aldehydes and dimethyl phosphite in solvent-free condition at 80 degrees C. The synthesis of alpha-acetoxyphosphonates through a one-pot reaction of aldehydes, dimethyl phosphite and acetic anhydride was also achieved using this catalyst in PEG at room temperature. The catalyst was recycled up to 10 times with little loss of activity. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.apcata.2013.07.001

文献信息

• Synthesis, characterization and catalytic properties of magnetic nanoparticle supported guanidine in base catalyzed synthesis of α-hydroxyphosphonates and α-acetoxyphosphonates
  作者：Amin Rostami、Bahareh Atashkar、Darush Moradi

  DOI：10.1016/j.apcata.2013.07.001

  日期：2013.10

  Magnetic nanoparticle Fe3O4-immobilized guanidine (MNPs-Guanidine) as a novel magnetically interphase nanocatalyst was synthesized and characterized. MNPs-Guanidine catalyzed the synthesis of alpha-hydroxyphosphonates from aldehydes and dimethyl phosphite in solvent-free condition at 80 degrees C. The synthesis of alpha-acetoxyphosphonates through a one-pot reaction of aldehydes, dimethyl phosphite and acetic anhydride was also achieved using this catalyst in PEG at room temperature. The catalyst was recycled up to 10 times with little loss of activity. (C) 2013 Elsevier B.V. All rights reserved.