(3,4-dimethoxyphenyl)(4-methoxyphenyl)sulfane | 1392308-26-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (3,4-dimethoxyphenyl)(4-methoxyphenyl)sulfane
• 英文别名: 1,2-Dimethoxy-4-(4-methoxyphenyl)sulfanylbenzene；1,2-dimethoxy-4-(4-methoxyphenyl)sulfanylbenzene
• CAS: 1392308-26-7
• 化学式: C₁₅H₁₆O₃S
• 分子量: 276.356
• InChiKey: DKHHXQBXABAIIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  53
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-碘苯甲醚 、 3,4-二甲氧基苯硫酚 在 chloro(1,5-cyclooctadiene)rhodium(I) dimer 、 三苯基膦 、 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以82%的产率得到(3,4-dimethoxyphenyl)(4-methoxyphenyl)sulfane
  参考文献：
  名称：

  A general rhodium-catalyzed cross-coupling reaction of thiols with aryl iodides

  摘要：

  The general procedure for the rhodium-catalyzed cross-coupling of thiols with aryl iodides is described. The catalytic system consists of 5 mol % of [RhCl(cod)](2) and 10 mol % of PPh3 as a ligand. A variety of aryl iodides reacted with thiols, giving aryl thioethers in good to excellent yields. It is important to note that the deactivated aryl iodides such as 4-iodoanisole is worked smoothly to provide the corresponding aryl thioethers in excellent yields. Functional groups such as free-amines, chloro, are all tolerated under the employed reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.06.054

文献信息

• A general rhodium-catalyzed cross-coupling reaction of thiols with aryl iodides
  作者：Chih-Shin Lai、Hsin-Lun Kao、Yan-Jhang Wang、Chin-Fa Lee

  DOI：10.1016/j.tetlet.2012.06.054

  日期：2012.8

  The general procedure for the rhodium-catalyzed cross-coupling of thiols with aryl iodides is described. The catalytic system consists of 5 mol % of [RhCl(cod)](2) and 10 mol % of PPh3 as a ligand. A variety of aryl iodides reacted with thiols, giving aryl thioethers in good to excellent yields. It is important to note that the deactivated aryl iodides such as 4-iodoanisole is worked smoothly to provide the corresponding aryl thioethers in excellent yields. Functional groups such as free-amines, chloro, are all tolerated under the employed reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.