sodium 2-methyl-4-chlorophenoxyacetate | 3653-48-3

• 物质功能分类: 化学农药原药 - 除草剂 - 其他除草剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: sodium 2-methyl-4-chlorophenoxyacetate
• 英文别名: mcpa sodium；4-chloro-2-methylphenoxyacetic acid sodium salt；2-methyl-4-chlorophenoxyacetic acid sodium salt；MCPA Na；sodium 4-chloro-2-methylphenoxy-acetate；MCPA-sodium；sodium;2-(4-chloro-2-methylphenoxy)acetate
• CAS: 3653-48-3
• 化学式: C₉H₈ClO₃*Na
• 分子量: 222.603
• InChiKey: STAPBGVGYWCRTF-UHFFFAOYSA-M

物化性质

• 物理描述：
  Methoxone sodium salt is a colorless plates. Corrosive. Used as an herbicide.
• 稳定性/保质期：
  有酚的刺激性气味。在生产过程中会使用到氯气和氯乙酸等有毒或腐蚀性的物质，因此设备需保持密闭状态，并要求操作人员穿戴好劳动保护用品。

计算性质

• 辛醇/水分配系数(LogP)：
  -2.22
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  49.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xn
• 危险类别码：
  R22
• WGK Germany：
  1
• 海关编码：
  2918990090
• 储存条件：
  库房应保持通风、低温和干燥，并与食品原料分开储存和运输。

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name : MCPA sodium salt monohydrate
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Acute toxicity, Inhalation (Category 4)
Acute toxicity, Dermal (Category 4)
Acute toxicity, Oral (Category 4)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Harmful if swallowed.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word Warning
Hazard statement(s)
H302 Harmful if swallowed.
H312 Harmful in contact with skin.
H332 Harmful if inhaled.
Precautionary statement(s)
P280 Wear protective gloves/ protective clothing.
Supplemental Hazard none
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R22 Harmful if swallowed.
S-phrase(s) none
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Formula : C9H8ClNaO3 · H2O
Molecular Weight : 240,62 g/mol
Component Concentration
MCPA sodium salt monohydrate
EC-No. 222-895-9 -
Index-No. 607-052-00-9

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Section 4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
no data available

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Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Hydrogen chloride gas
Nature of decomposition products not known.
Carbon oxides, Hydrogen chloride gas, Sodium oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure
adequate ventilation. Avoid breathing dust.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end uses
no data available

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and no data available
boiling range
g) Flash point no data available
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

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Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. May cause respiratory tract irritation.
Ingestion Harmful if swallowed.
Skin May be harmful if absorbed through skin. May cause skin irritation.
Eyes May cause eye irritation.
Additional Information
RTECS: Not available

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

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Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

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Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
no data available

---

Section 16. OTHER INFORMATION
Further information
Copyright 2012 Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See
and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

制备方法与用途

概述

二甲四氯钠常与其他成分复配作为除草剂使用。如果吸入二甲四氯钠，请将患者移至新鲜空气处；若皮肤接触，应脱去污染衣物，并用肥皂水和清水彻底冲洗皮肤，如有不适请就医；如眼睛接触到二甲四氯钠，应分开眼睑并用流动清水或生理盐水冲洗，随后立即就医；如果误食，应立即漱口，禁止催吐，尽快就医。

应用

二甲四氯钠常与其他成分复配作为除草剂使用。其应用示例如下：

1. 制备含有二甲四氯钠和辛酰溴苯腈组合物的农药水悬浮剂：此农药主要由二甲四氯钠盐、辛酰溴苯腈、润湿分散剂（由蓖麻油聚醚、环氧乙烯环氧丙烷嵌段、脂肪醇聚氧乙烯醚及十二烷基苯磺酸钙组成）、四甲苯类混合物1500#和水构成。该配方旨在使二甲四氯钠盐与辛酰溴苯腈组合物的农药水悬浮剂具有良好的稳定性，高悬浮率，并在冷贮或热贮后不易产生结晶、分层或固化现象。相较于现有技术，使用更加环保安全，且复配可弥补单一成分使用的局限性及抗药性问题，在植物表面有较好的粘附性和耐雨水冲刷能力，除草效果更宽广、持久。

2. 制备含有噁嗪草酮和二甲四氯钠的除草剂组合物：该组合物由活性成分噁嗪草酮与二甲四氯钠构成，二者重量比为99:1至1:99（优选15:1至1:15），累计量占组合物总重0.1%至82%（优选2%-20%）。此组合物合理搭配，防效显著优于各成分单独使用时的表现，具备增效作用。它适用于一次施药就能防治水稻田中的禾本科、莎草科及阔叶杂草等多类杂草，减少施药次数和成本，延缓杂草抗性的产生，并对作物安全无害。

用途

• 用于小粒谷物、水稻、豌豆、草坪和非耕作区：防治一年生或多年生阔叶杂草。
• 属于激素型除草剂。
• 用于防除水稻、麦类、玉米、高粱、甘蔗、亚麻等作物田中的莎草科及多种阔叶杂草。

生产方法

二甲四氯钠由邻甲苯酚与氢氧化钠反应生成邻甲酚钠，再与其与氯乙酸钠缩合后经盐酸酸化处理；随后进行氯化反应，并使用氢氧化钠成盐制得2-甲-4-氯钠。

类别

• 农药
• 毒性分级：中毒
• 急性毒性：
  • 口服-大鼠 LD50: 800毫克/公斤
  • 口服-小鼠 LD50: 450毫克/公斤
• 燃烧时产生有毒氯化物气体。
• 库房应通风、低温干燥，且需与食品原料分开存储和运输。
• 灭火剂：干粉、泡沫或砂土。

反应信息

• 作为反应物：
  描述：

  sodium 2-methyl-4-chlorophenoxyacetate 在 盐酸 作用下， 以 水 为溶剂， 生成 2-甲基-4-氯苯氧乙酸
  参考文献：
  名称：

  Finding new elicitors that induce resistance in rice to the white-backed planthopper Sogatella furcifera

  摘要：

  Herein we report a new way to identify chemical elicitors that induce resistance in rice to herbivores. Using this method, by quantifying the induction of chemicals for GUS activity in a specific screening system that we established previously, 5 candidate elicitors were selected from the 29 designed and synthesized phenoxyalkanoic acid derivatives. Bioassays confirmed that these candidate elicitors could induce plant defense and then repel feeding of white-backed planthopper Sogatella furcifera. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.10.041
• 作为产物：
  描述：

  2-(4-氯-2-甲基-苯氧基)乙酸丁酯 在 sodium hydroxide 作用下， 反应 4.0h， 以223.74 g的产率得到sodium 2-methyl-4-chlorophenoxyacetate
  参考文献：
  名称：

  一种苯氧羧酸盐类除草剂的制备方法

  摘要：

  本发明提供了一种苯氧羧酸盐类除草剂的制备方法，包括：S1、将苯酚或邻甲酚在碱性物质作用下，与氯代羧酸酯进行缩合反应，得到苯氧羧酸酯；所述氯代羧酸酯通式为ClR1COOR，R1为C1～3的亚烷基或次烷基，R为C1～10的烷基或C3～10的环烷基；S2、将所述苯氧羧酸酯在第一催化剂和第二催化剂作用下，与氯化剂进行选择性氯化，得到式I所示氯代苯氧羧酸酯；R3为H、Cl或CH3；所述第一催化剂选自路易斯酸，第二催化剂选自C5～22的硫醚类、噻唑类、异噻唑类或噻吩类化合物；S3、将所述氯代苯氧羧酸酯与碱性化合物混合，进行碱解反应，得到苯氧羧酸盐类除草剂。本发明能改善产品品质和生产操作环境，三废少。

  公开号：

  CN108947811A
• 作为试剂：
  描述：

  2-甲基-4-氯苯氧乙酸 、 sodium hydroxide 在 甲醇 、 sodium 2-methyl-4-chlorophenoxyacetate 作用下， 以 甲醇 为溶剂， 生成 sodium 2-methyl-4-chlorophenoxyacetate
  参考文献：
  名称：

  Process for preparing solid, free-flowing water-soluble salts of

  摘要：

  制备固体、自由流动的水溶性芳氧基-C.sub.1-C.sub.4-烷基羧酸盐的过程，是通过将芳氧基-C.sub.1-C.sub.4-烷基羧酸与盐形成基反应，在存在或不存在适用于共沸水的带引剂的熔融中进行盐形成，或在存在适用于共沸水的带引剂的溶液中进行盐形成，并在反应过程中或随后从反应混合物中去除带引剂，然后以通常的方式分离固体盐。

  公开号：

  US05939584A1

文献信息

• HERBICIDAL COMPOSITIONS
  申请人：Bayer Aktiengesellschaft

  公开号：US20220053762A1

  公开（公告）日：2022-02-24

  The present invention provides compositions comprising herbicidally active compounds (A) and (B), where (A) represents one or more compounds of the general formula (I) or agrochemically compatible salts thereof [component (A)], and (B) represents one or more herbicides [component (B)]. The application further relates to a method and to the use of the herbicidal composition according to the invention for controlling harmful plants or for regulating growth.

  本发明提供了包含除草活性化合物（A）和（B）的组合物，其中（A）代表通式（I）的一个或多个化合物或其农药兼容盐[组分（A）]，（B）代表一个或多个除草剂[组分（B）]。该申请进一步涉及一种方法和利用本发明的除草组合物来控制有害植物或调节生长。
• Benzoate derivative, method of preparing the same and use thereof
  申请人：NIHON NOHYAKU CO., LTD.

  公开号：EP0034457A1

  公开（公告）日：1981-08-26

  Novel benzoate derivatives having a powerful herbicidal effect on various weeds grown in paddy fields, upland fields, and other places have been found out, which are represented by the formula wherein X is -SR, -O-(CH2CH2O)-n R, -OCH2CH2SR, herein R being lower alkyl and n being an integer of 1 to 3.

  新发现的苯甲酸酯衍生物对生长在水田、高地和其他地方的各种杂草具有强大的除草效果，它们由式表示 其中 X 是 -SR、-O-(CH2CH2O)-n R、-OCH2CH2SR、 其中 R 为低级烷基，n 为 1 至 3 的整数。
• Pesticidal compositions comprising diarylalkanes
  申请人：NIPPON PETROCHEMICALS CO., LTD.

  公开号：EP0753255A2

  公开（公告）日：1997-01-15

  A pesticidal composition to noxious organisms which comprises a diarylalkane and an active component effective for killing or repelling noxious organisms and the diarylalkane is at least one member selected from the group consisting of butyl diphenylmethane, butyl-1,1-diphenylethane and butyl-1,2-diphenylethane. The used diarylalkane has a high dissolving power to the effective component, a high boiling point and a high flash point with low unpleasant smell and does not deteriorate the effective component in the pesticidal composition.

  一种杀灭有害生物的杀虫组合物，它包括一种二芳基烷烃和一种有效杀灭或驱赶有害生物的活性成分，二芳基烷烃至少是选自丁基二苯基甲烷、丁基-1,1-二苯基乙烷和丁基-1,2-二苯基乙烷组中的一种。所使用的二芳基烷烃对有效成分有较高的溶解能力，沸点高，闪点高，气味低，不会使杀虫组合物中的有效成分变质。
• AGENT FOR IMPROVING MITOCHONDRIAL FUNCTION AND ANTI-AGING COMPOSITION
  申请人：Showa Denko K.K.

  公开号：EP3213739A1

  公开（公告）日：2017-09-06

  Provided is an agent for improving mitochondrial function including a hydroxycitric acid derivative represented by the following Formula (I) or a salt thereof, as an active ingredient [(In Formula (I), R1 and R2 each independently represent a hydrogen atom or any one group selected from the group represented by the following Formula (Ia) (here, R1 and R2 do not represent hydrogen atoms at the same time), X1 to X3 each independently represent a nitrogen or an oxygen atom, and R3, R4, R5, R3', R4', and R5' each independently represent a hydrogen atom, or a chained hydrocarbon group (here, in a case where X1, X2, and X3 each independently represent an oxygen atom, corresponding R3', R4', or R5' does not exist). In Formula (Ia), R6 to R8 each independently represent a hydrogen atom, an aryl group, or a chained hydrocarbon group having 1 to 30 carbon atoms].

  提供了一种改善线粒体功能的制剂，包括由下式(I)代表的羟基柠檬酸衍生物或其盐，作为活性成分[(在式(I)中，R1和R2各自独立地代表氢原子或选自下式(Ia)所代表的基团中的任意一个基团（此处、R1和R2不同时代表氢原子），X1至X3各自独立地代表氮原子或氧原子，R3、R4、R5、R3'、R4'和R5'各自独立地代表氢原子或链状烃基（此处，在X1、X2和X3各自独立地代表氧原子的情况下，不存在相应的R3'、R4'或R5'）。在式 (Ia)中，R6 至 R8 各自独立地代表氢原子、芳基或具有 1 至 30 个碳原子的链状烃基]。
• SKIN BARRIER FUNCTION-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN BARRIER FUNCTION
  申请人：Showa Denko K.K.

  公开号：EP3213753A1

  公开（公告）日：2017-09-06

  The present invention provides a skin barrier function-improving agent including an inositol derivative as an active ingredient in which inositol and saccharide are bonded, and a composition for improving a skin barrier function including the above skin barrier function-improving agent and a pharmacologically acceptable carrier.

  本发明提供了一种皮肤屏障功能改善剂，其中包括一种以肌醇衍生物为活性成分、肌醇和糖键合的皮肤屏障功能改善剂，以及一种用于改善皮肤屏障功能的组合物，其中包括上述皮肤屏障功能改善剂和药理学上可接受的载体。