1-(Acetyloxy)-3-hydroxypropan-2-YL hexadecanoate | 94720-08-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1-(Acetyloxy)-3-hydroxypropan-2-YL hexadecanoate
• 英文别名: (1-acetyloxy-3-hydroxypropan-2-yl) hexadecanoate
• CAS: 94720-08-8
• 化学式: C₂₁H₄₀O₅
• 分子量: 372.5
• InChiKey: ZZMHMQZJHUCQIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  26
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] PROCESS FOR REGIOSELECTIVE PREPARATION OF GLYCEROL, DERIVATIVE AND INTERMEDIATE THEREFOR<br/>[FR] PROCEDE DE PREPARATION STEREOSELECTIVE DE DERIVES DE GLYCEROL ET PRODUITS INTERMEDIAIRES UTILISES DANS CE PROCEDE
  申请人：ENZYCHEM CO LTD

  公开号：WO2005090274A1

  公开（公告）日：2005-09-29

  Disclosed is a process for regioselective preparation of l-palmitoyl-2-linoleoyl-3-acetylglycerol which is known as having activities for proliferation of hematopoietic stem cells and megakaryocytes, and an intermediate for the same. The process for preparation of l-palmitoyl-2-linoleoyl-3-acetylglycerol includes the steps of obtaining (2-alkoxy-2-methyl-[l,3]-dioxolane-4-yl)methanol by reacting glycerol and trialkylorthoacetate; obtaining 1-acetyl glycerol by hydrolyzing (2-alkoxy-2-methyl-[l,3]-dioxolane-4-yl)methanol; obtaining l-palmitoyl-3-acetyl glycerol by reacting 1-acetyl glycerol and palmitic acid derivative; and reacting l-palmitoyl-3-acetyl glycerol and linoleic acid derivative. l-palmitoyl-2-linoleoyl-3-acetylglycerol can also be prepared by the steps of obtaining l-palmitoyl-3-acetyl glycerol by hydrolyzing palmitic acid (2-alkoxy-2-methyl-[l,3] dioxolane- 4-yl)methyl ester; and reacting l-palmitoyl-3-acetyl glycerol and linoleic acid derivative.

  公开了一种用于选择性区域制备l-棕榈酰-2-亚油酰-3-乙酰甘油的过程，该甘油被认为具有促进造血干细胞和巨核细胞增殖的活性，以及用于制备该甘油的中间体。制备l-棕榈酰-2-亚油酰-3-乙酰甘油的过程包括以下步骤：通过将甘油和三烷基正醋酸酯反应得到(2-烷氧基-2-甲基-[1,3]-二氧兰-4-基)甲醇；通过水解(2-烷氧基-2-甲基-[1,3]-二氧兰-4-基)甲醇得到1-乙酰甘油；通过将1-乙酰甘油和棕榈酸衍生物反应得到l-棕榈酰-3-乙酰甘油；通过将l-棕榈酰-3-乙酰甘油和亚油酸衍生物反应得到l-棕榈酰-2-亚油酰-3-乙酰甘油。l-棕榈酰-2-亚油酰-3-乙酰甘油也可以通过以下步骤制备：通过水解棕榈酸(2-烷氧基-2-甲基-[1,3]二氧兰-4-基)甲酯得到l-棕榈酰-3-乙酰甘油；然后将l-棕榈酰-3-乙酰甘油和亚油酸衍生物反应。
• POLYPROPYLENE-BASED FILM OR SHEET WITH ANTI-FOG PROPERTIES
  申请人：Akzo Nobel Chemicals International B.V.

  公开号：EP3428226A1

  公开（公告）日：2019-01-16

  Polypropylene composition comprising 0.7-4.0 wt% of glycerides of formula (I): wherein the R-groups are selected from hydrogen, acetyl groups, palmityl groups, and stearyl groups, wherein one R-group is selected from palmityl and stearyl groups and 30-50% of the total number of R-groups is an acetyl group, and wherein the weight ratio glycerides of formula (I) containing palmityl groups to glycerides of formula (I) containing stearyl groups is in the range 0.25-4.0.

  聚丙烯组合物，包含 0.7-4.0 wt%的式 (I) 甘油酯： 其中 R 基团选自氢、乙酰基、棕榈酰基和硬脂酰基、 其中一个 R 基团选自棕榈酰基和硬脂酰基，R 基团总数的 30-50%为乙酰基、 其中含有棕榈酰基的式(I)甘油酯与含有硬脂酰基的式(I)甘油酯的重量比范围为 0.25-4.0。