n-pentyl diphenylmethyl ether | 42100-71-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: n-pentyl diphenylmethyl ether
• 英文别名: pentyl benzhydryl ether；Amylbenzhydrylaether；(Pentoxy-phenylmethyl)benzene；[pentoxy(phenyl)methyl]benzene
• CAS: 42100-71-0
• 化学式: C₁₈H₂₂O
• 分子量: 254.372
• InChiKey: QQWJLIDABSWLBH-UHFFFAOYSA-N

物化性质

• 沸点：
  338.0±11.0 °C(Predicted)
• 密度：
  0.984±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二苯甲醇 、 戊醇 在 二苯基溴甲烷 作用下， 以 neat (no solvent) 为溶剂， 反应 22.0h， 以92%的产率得到n-pentyl diphenylmethyl ether
  参考文献：
  名称：

  醇之间的有机卤化物催化的脱水O-烷基化：脂肪族醚合成的简便醚化方法

  摘要：

  有机卤化物有效地催化了醇之间的脱水O-烷基化反应，为制备有用的对称和不对称脂族醚提供了选择性，实用，绿色，易于扩展的均和交叉醚化方法。

  DOI：

  10.1039/c5gc00284b

文献信息

• Nafion-catalyzed preparation of benzhydryl ethers
  作者：Marina A Stanescu、Rajender S Varma

  DOI：10.1016/s0040-4039(02)01755-0

  日期：2002.10

  Nafion-H is found to be an efficient and recyclable catalyst for the preparation of diphenylmethyl ethers of alcohols.

  发现Nafion-H是用于制备醇的二苯甲基醚的有效且可回收的催化剂。
• 三甲基卤硅烷催化醇合成醚的方法
  申请人：扬州大学

  公开号：CN112047816B

  公开（公告）日：2023-05-16

  本发明公开了一种三甲基卤硅烷催化醇合成醚的方法。所述方法在空气或氮气气氛、无溶剂、无过渡金属催化剂的条件下，直接以醇类化合物为原料、三甲基卤硅烷为催化剂，一步选择性脱水反应合成对称或非对称醚。本发明方法避免了强酸、强碱，毒性高、不稳定、价格偏高的有机伯卤代物的使用，缩短了合成步骤，提高了合成效率，且反应具有很好的选择性，可优先得到目标醚产物。
• Organic Reactions Catalyzed by Methylrhenium Trioxide:  Dehydration, Amination, and Disproportionation of Alcohols
  作者：Zuolin Zhu、James H. Espenson

  DOI：10.1021/jo951613a

  日期：1996.1.1

  Methylrhenium trioxide (MTO) is the first transition metal complex in trace quantity to catalyze the direct formation of ethers from alcohols. The reactions are independent of the solvents used: benzene, toluene, dichloromethane, chloroform, acetone, and in the alcohols themselves. Aromatic alcohols gave better yields than aliphatic. Reactions between two different alcohols could also be used to prepare unsymmetric ethers, the best yields being obtained when one of the alcohols is aromatic. MTO also catalyzes the dehydration of alcohols to form olefins at room temperature, aromatic alcohols proceeding in better yield. When primary (secondary) amines were used as the limiting reagent, direct amination of alcohols catalyzed by MTO gave good yields of the expected secondary (tertiary) amines at room temperature. Disproportionation of alcohols to alkanes and carbonyl compounds was also observed for aromatic alcohols in the presence of MTO. On the basis of the results of this investigation and a comparison with the interaction between MTO and water, a concerted process and a mechanism involving carbocation intermediates have been suggested.
• PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS
  申请人：NYMOX CORPORATION

  公开号：EP0983222B1

  公开（公告）日：2007-11-28
• Cosmetic And Dermatological Photoprotective Preparation With Improved Water Resistance
  申请人：Von Thaden Stefanie

  公开号：US20140140940A1

  公开（公告）日：2014-05-22

  The invention relates to cosmetic and dermatological photoprotective preparations comprising, in addition to UV filter substances, polyglyceryl-10 stearate as emulsifier. Said preparations have improved water resistance.