N,N'-(1,3-phenylenebismethylene)bisphthalimide | 27199-63-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N,N'-(1,3-phenylenebismethylene)bisphthalimide
• 英文别名: N,N'-m-phenylenedimethyl-bis-phthalimide；N,N'-m-xylylene-bis-phthalimide；N,N'-m-Xylylen-bis-phthalimid；1,3-Bis[(isoindole-1,3-dione-2-yl)methyl]benzene；m-Xylylenediamine-bis(phthalimide)；2-[[3-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]methyl]isoindole-1,3-dione
• CAS: 27199-63-9
• 化学式: C₂₄H₁₆N₂O₄
• 分子量: 396.402
• InChiKey: NTDWUIGQTLMPCZ-UHFFFAOYSA-N

物化性质

• 熔点：
  235-237 °C
• 沸点：
  604.2±48.0 °C(Predicted)
• 密度：
  1.455±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N'-(1,3-phenylenebismethylene)bisphthalimide 在 吡啶 、 氢氧化钾 作用下， 生成 N,N′-m-xylylene-bis-benzamide
  参考文献：
  名称：

  Window observers for linear systems

  摘要：

  Given a linear system (x) over dot = Ax + Bu with output y = Cx and a window function omega>(*) over bar * (t), i.e., For Allt, omega>(*) over bar * (t) is an element of {0,1}, and assuming that the window function is Lebesgue measurable, we refer to the following observer, (x) over cap = A (x) over cap + Bu + omega>(*) over bar * (t)LC(x - (x) over cap) as a window observer. The stability issue is treated in this paper. It is proven that for linear time-invariant systems, the window observer can be stabilized by an appropriate design under a very mild condition on the window functions, albeit for linear time-varying system, some regularity of the window functions is required to achieve observer designs with the asymptotic stability. The corresponding design methods are developed. An example is included to illustrate the possible applications.

  DOI：

  10.1155/s1024123x0000140x
• 作为产物：
  描述：

  间苯二甲胺 、 苯酐 在 溶剂黄146 作用下， 以91%的产率得到N,N'-(1,3-phenylenebismethylene)bisphthalimide
  参考文献：
  名称：

  Thalidomide Analogs from Diamines: Synthesis and Evaluation as Inhibitors of TNF-.ALPHA. Production

  摘要：

  通过将不同的二胺与邻苯二甲酸酐或 3-硝基邻苯二甲酸酐缩合，制备出了 14 种含有两个邻苯二甲酰亚氨基单元的沙利度胺类似物，收率高达 83-94%。对这些化合物作为 TNF-α 生成抑制剂进行了体外研究。带有氨基和硝基的化合物的抑制率较高，并可通过增加邻苯二甲酰亚胺基团之间的间隔尺寸来调节。

  DOI：

  10.1248/cpb.55.223

文献信息

• Further studies on bis-charged tetraazacyclophanes as potent inhibitors of small conductance Ca2+-activated K+ channels
  作者：Donglai Yang、Lejla Arifhodzic、C. Robin Ganellin、Donald H. Jenkinson

  DOI：10.1016/j.ejmech.2013.02.029

  日期：2013.5

  Previously, quinolinium-based tetraazacyclophanes, such as UCL 1684 and UCL 1848, have been shown to be extraordinarily sensitive to changes in chemical structure (especially to the size of the cyclophane system) with respect to activity as potent non-peptidic blockers of the small conductance Ca2+-activated K+ ion channels (SKCa). The present work has sought to optimize the structure of the linking

  以前，已证明基于喹啉鎓的四氮杂环烷酮（例如UCL 1684和UCL 1848）作为有效的小肽非肽类阻滞剂，对化学结构的变化（尤其是对环庚烷体系的大小）非常敏感。电导Ca 2+激活的K +离子通道（SK Ca）。当前的工作试图优化UCL 1848中连接链的结构。我们报道了29个UCL 1848类似物的合成和SK Ca通道阻滞活性，其中UCL 1848的中心CH 2被其他基团X或取代。 Y = O，S，CF 2，C O，CHOH，C C，CHCH，CHMe，以探索键长或柔韧性的细微变化是否可以进一步提高效力。通过合成和测试带有取代基（NO 2，NH 2，CF 3，F，Cl，CH 3，OCH 3，OCF 3， OH）在氨基喹啉鎓环的5、6或7个位置上。与我们之前的工作一样，测定了每种化合物对大鼠交感神经元后超极化（AHP）的抑制作用，这种作用是由SK Ca通道的SK3亚型介导的。一种新化合物（39，R
• OXYGEN SCAVENGING MOLECULES, ARTICLES CONTAINING SAME, AND METHODS OF THEIR USE
  申请人：Deshpande Girish Nilkanth

  公开号：US20110251395A1

  公开（公告）日：2011-10-13

  The invention relates to compounds of the structure of formula I and II: where X is selected from the group consisting of O, S and NH; Y, A and B are independently selected from the group consisting of N and CH; D, E and F are independently selected from the group consisting of CH, N, O and S; the symbol represents a single or a double bond; and R 1 , R 2 and R 3 are independently selected from the group consisting of H, electron withdrawing groups and electron releasing groups. In other embodiments, the compounds are used as oxygen scavengers and in barrier compositions and articles.

  该发明涉及结构为公式I和II的化合物：其中X从O、S和NH组成的群体中选择；Y、A和B从N和CH组成的群体中独立选择；D、E和F从CH、N、O和S组成的群体中独立选择；符号代表单键或双键；R1、R2和R3从H、电子吸引基团和电子释放基团组成的群体中独立选择。在其他实施方式中，这些化合物被用作氧清除剂，以及在屏障组合物和制品中使用。
• New Arylpiperazines with Flexible versus Partly Constrained Linker as Serotonin 5-HT_1A/5-HT₇Receptor Ligands
  作者：Piotr Kowalski、Katarzyna Mitka、Jolanta Jaśkowska、Beata Duszyńska、Andrzej J. Bojarski

  DOI：10.1002/ardp.201300011

  日期：2013.5

  A series of new long‐chain arylpiperazine (LCAP) derivatives with flexible and partly constrained alkyl linker were synthesized and investigated in vitro as potential serotonin 5‐HT1A and 5‐HT7 receptor ligands. The compounds were prepared by a two‐step procedure using naphthalimide and 2H‐1,3‐benzoxazine‐2,4(3H)‐dione as imides, and 1‐(2‐methoxyphenyl)piperazine (o‐OMe‐PhP) and 1,2,3,4‐tetrahydroisoquinoline

  合成了一系列具有灵活且部分受限的烷基接头的新型长链芳基哌嗪 (LCAP) 衍生物，并在体外作为潜在的血清素 5-HT1A 和 5-HT7 受体配体进行了研究。使用萘二甲酰亚胺和 2H-1,3-苯并恶嗪-2,4(3H)-二酮作为酰亚胺，以及 1-(2-甲氧基苯基)哌嗪 (o-OMe-PhP) 和 1 ,2,3,4-四氢异喹啉 (THIQ) 作为胺药效团。间隔结构的修改包括引入灵活的五亚甲基和六亚甲基链以及部分受限的间和对二甲苯基部分。一般而言，新化合物对 5-HT1A 的活性高于对 5-HT7 受体的活性，并且 o-OMe-PhP 衍生物比其各自的 THIQ 类似物表现出更高的亲和力。间隔修饰对观察到的体外活性几乎没有影响。在 o-OMe-PhP 系列中，除了含有间二甲苯基部分的配体的结合略有减少外，化合物对两种受体的效力没有实质性变化，而对于 THIQ 衍生物，具有明确的构效关系仅在化合物与
• Oxygen Scavenging Molecules, Articles Containing Same, And Methods Of Their Use
  申请人：Deshpande Girish Nilkanth

  公开号：US20080277622A1

  公开（公告）日：2008-11-13

  The invention relates to compounds of the structure of formula I and II: where X is selected from the group consisting of O, S and NH; Y, A and B are independently selected from the group consisting of N and CH; D, E and F are independently selected from the group consisting of CH, N, O and S; the symbol — represents a single or a double bond; and R 1 , R 2 and R 3 are independently selected from the group consisting of H, electron withdrawing groups and electron releasing groups. In other embodiments, the compounds are used as oxygen scavengers and in barrier compositions and articles.

  本发明涉及结构式I和II的化合物：其中X选自O，S和NH组成的群体；Y，A和B独立地选自N和CH组成的群体；D，E和F独立地选自CH，N，O和S组成的群体；符号—表示单键或双键；R1，R2和R3独立地选自H，电子提取基团和电子释放基团组成的群体。在其他实施例中，这些化合物被用作氧气清除剂和隔离物组成和物品。
• 메타-크실릴렌디아민류의 제조 방법 및 비스아미드 화합물의 제조 방법
  申请人：MITSUI CHEMICALS,INC. 미쯔이가가꾸가부시끼가이샤(519987065690)

  公开号：KR20160009679A

  公开（公告）日：2016-01-26

  본 발명의 메타-크실릴렌디아민류의 제조 방법은, 모노할로겐화 벤젠류와, 포름알데히드류와, 제1급 아미드기 또는 제2급 아미드기를 갖는 아미드 화합물을, 산성 액체의 존재 하에서 반응시키는 반응 공정과, 모노할로겐화 벤젠류에서 유래되는 할로겐 원자를 수소 원자로 치환하는 탈할로겐화 공정과, 아미드 화합물에서 유래되는 제1급 아미드기 또는 제2급 아미드기를 아미노기로 변환하는 탈보호 공정을 포함한다. 반응 공정에 있어서, 산성 액체가 무기산을 함유하고, 모노할로겐화 벤젠류에 대한, 무기산의 수소 원자의 당량비가 16을 초과하고, 산성 액체 중의 무기산의 농도가 80질량％를 초과하고, 반응 온도가 40℃를 초과하고 있다.

  该专利的方法涉及生产甲基-对甲苯二胺类化合物，包括在酸性液体存在下使单卤代苯类、甲醛和含有一级或二级酰胺基团的酰胺化合物发生反应的反应步骤，以及将单卤代苯类中的卤原子置换为氢原子的去卤化步骤，以及将酰胺化合物中的一级或二级酰胺基团转化为氨基的去保护步骤。在反应步骤中，酸性液体含有无机酸，对于单卤代苯类，无机酸的氢原子当量比超过16，酸性液体中无机酸的浓度超过80质量％，反应温度超过40℃。