4,5α-epoxy-3,6-dimethoxy-17-methyl-morphina-6,8(14)-diene | 115-37-7

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 4,5α-epoxy-3,6-dimethoxy-17-methyl-morphina-6,8(14)-diene
• 英文别名: Thebain；O-methyl-oripavine；paramorphine；thebaine；(4R,7aR)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline
• CAS: 115-37-7；23979-17-1；23979-19-3
• 化学式: C₁₉H₂₁NO₃
• 分子量: 311.381
• InChiKey: FQXXSQDCDRQNQE-OJBAKJFDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  30.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] PROCESS FOR OBTAINING 3,14-DIACETYLOXYMORPHONE FROM ORIPAVINE<br/>[FR] PROCÉDÉ D'OBTENTION DE 3,14-DIACÉTYLOXYMORPHONE À PARTIR D'ORIPAVINE
  申请人：ALCALIBER INVESTIGACIÓN DESARROLLO E INNOVACIÓN S L

  公开号：WO2017207519A1

  公开（公告）日：2017-12-07

  The present invention relates to a new process for obtaining 3,14-diacetyloxymorphone from oripavine, a process to transform the obtained 3,14-diacetyloxymorphone into a noroxymorphone and a process to transform said noroxymorphone into naloxone, naltrexone, nalbuphine, nalfurafine or nalmefene.

  本发明涉及一种从欧洲罂粟碱中获得3,14-二乙酰氧吗啡酮的新工艺，将获得的3,14-二乙酰氧吗啡酮转化为诺罂吗啡的过程，以及将所述诺罂吗啡转化为纳洛酮、纳曲酮、纳布啡、纳福啡或纳美非那的工艺。
• PROCESS FOR IMPROVED OXYCODONE SYNTHESIS
  申请人：RHODES TECHNOLOGIES

  公开号：US20170022210A1

  公开（公告）日：2017-01-26

  Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.

  提供了制备羟考酮的工艺。所述工艺包括在三氟乙酸和/或乙二醇存在下对14-羟基可待因酮盐进行氢化的步骤。
• PROCESS FOR OBTAINING 3,14-DIACETYLOXYMORPHONE FROM ORIPAVINE
  申请人：Alcaliber Investigacion Desarrollo e Innovacion, S.L.

  公开号：EP3252055A1

  公开（公告）日：2017-12-06

  The present invention relates to a new process for obtaining 3,14-diacetyloxymorphone from oripavine, a process to transform the obtained 3,14-diacetyloxymorphone into a noroxymorphone and a process to transform said noroxymorphone into naloxone, naltrexone, nalbuphine, nalfurafine or nalmefene.

  本发明涉及一种从奥列巴文获得 3,14-二乙酰氧基吗啡酮的新工艺，一种将获得的 3,14-二乙酰氧基吗啡酮转化为去甲氧吗啡酮的工艺，以及一种将所述去甲氧吗啡酮转化为纳洛酮、纳曲酮、纳布啡、纳氟啡或纳美芬的工艺。
• Process for improved oxycodone synthesis
  申请人：RHODES TECHNOLOGIES

  公开号：US10844072B2

  公开（公告）日：2020-11-24

  Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.

  提供了制备羟考酮的工艺。所述工艺包括一个步骤，即在三氟乙酸和/或乙二醇存在下氢化 14-羟基可待因酮盐。
• Processes for Making Opioids Including 14-Hydroxycodeinone and 14-Hydroxymorphinone
  申请人：Johnson Matthey Public Limited Company

  公开号：US20190187914A9

  公开（公告）日：2019-06-20

  Improved processes for making opioid products having low impurity levels including making 14-hydroxycodeinone and 14-hydroxymorphinone from thebaine and oripavine, respectively.