5-[N-benzyl-N-(3-chloropropyl)-amino]-4-chloro-2-methyl-3(2H)-pyridazinone | 268210-67-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-[N-benzyl-N-(3-chloropropyl)-amino]-4-chloro-2-methyl-3(2H)-pyridazinone
• 英文别名: 5-[N-Benzyl-N-(3-chloro propyl)amino]-4-chloro-2-methyl-3(2H)-pyridazinone；5-[benzyl(3-chloropropyl)amino]-4-chloro-2-methylpyridazin-3-one
• CAS: 268210-67-9
• 化学式: C₁₅H₁₇Cl₂N₃O
• 分子量: 326.225
• InChiKey: MZRNVSPHWIEXGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  35.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-[N-benzyl-N-(3-chloropropyl)-amino]-4-chloro-2-methyl-3(2H)-pyridazinone 、 sodium sulfide nonahydrate 以 甲醇 、 水 为溶剂， 生成 5-Benzyl-8-methyl-2,3,4,5-tetrahydro-9(8H)-pyridazino[4,5-b][ 1,5]thiazepinone
  参考文献：
  名称：

  Pyridazino(4,5-b)(1,5)oxazepinone, -thiazepinone and -diazepinone compounds

  摘要：

  式(I)的吡啶并[4,5-b][1,5]噁唑啉酮、噻唑啉酮和二氮杂啉酮化合物及其互变异构体和这些化合物的酸加成盐具有增强记忆和神经保护作用。

  公开号：

  US06602865B1
• 作为产物：
  描述：

  5-[N-benzyl-N-(3-hydroxypropyl)amino]-4-chloro-2-methyl-3(2H)-pyridazinone 在 4-二甲氨基吡啶 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 5-[N-benzyl-N-(3-chloropropyl)-amino]-4-chloro-2-methyl-3(2H)-pyridazinone
  参考文献：
  名称：

  Pyridazino(4,5-b)(1,5)oxazepinone, -thiazepinone and -diazepinone compounds

  摘要：

  式(I)的吡啶并[4,5-b][1,5]噁唑啉酮、噻唑啉酮和二氮杂啉酮化合物及其互变异构体和这些化合物的酸加成盐具有增强记忆和神经保护作用。

  公开号：

  US06602865B1

文献信息

• NOVEL TYPE CONDENSED PYRIDAZINONE COMPOUNDS
  申请人：GYOGYSZERKUTATO INTEZET KFT.

  公开号：EP1129097B1

  公开（公告）日：2003-01-29
• US6602865B1
  申请人：——

  公开号：US6602865B1

  公开（公告）日：2003-08-05
• [EN] NOVEL TYPE CONDENSED PYRIDAZINONE COMPOUNDS<br/>[FR] NOUVEAUX TYPES DE COMPOSES DE PYRIDAZINONE CONDENSES
  申请人：GYOGYSZERKUTATO INTEZET

  公开号：WO2000027851A1

  公开（公告）日：2000-05-18

  Novel pyridazino[4,5-b][1,5]oxazepinone, thiazepinone and diazepinone derivatives of general formula (I) wherein: R stands for hydrogen atom or a group of formula NHR4, wherein: R4 stands for hydrogen, C¿1-4? alkyl or C2-5 acyl group, R?1¿ stands for C¿1-4? alkyl or C2-4 alkenyl group, which may be substituted by a phenyl group, or phenyl group, W stands for methylene or carbonyl group, X and Y stand independently for oxygen or sulphur atom, SO, SO2 or NR?3¿ group, wherein R3 is hydrogen atom, C¿1-4? alkyl group or a group of formula (II), wherein R?2¿ stands for hydrogen or halogen atom, C¿1-4? alkoxy or nitro group or a group of formula NHR?4¿, wherein R4 has the above meaning, and Z stands for methylene or carbonyl group, further n has a value of 0, 1 or 2, with the proviso that when any of X or Y stands for oxygen or sulphur atom, SO or SO¿2? group or a group of formula NR?3¿, wherein R3 stands for hydrogen atom or C¿1-4? alkyl group, then the other may stand only for an NR?3¿ group, wherein R3 stands for a group of formula (II) - wherein R2, Z and n have the above meanings - and their tautomers and the acid-addition salts of all these compounds. The compounds according to the invention show memory-enhancing and neuroprotective properties.
• Pyridazino(4,5-b)(1,5)oxazepinone, -thiazepinone and -diazepinone compounds
  申请人：IVAX Drug Research Institute, Ltd.

  公开号：US06602865B1

  公开（公告）日：2003-08-05

  Pyridazino(4,5-b)(1,5)oxazepinone, thiazepinone and diazepinone compounds of formula(I) and their tautomers and the acid-addition salts of all these compounds show memory-enhancing and neuroprotective properties.

  式(I)的吡啶并[4,5-b][1,5]噁唑啉酮、噻唑啉酮和二氮杂啉酮化合物及其互变异构体和这些化合物的酸加成盐具有增强记忆和神经保护作用。