(R)-diethyl 2-(1-(2-bromophenyl)-2-nitroethyl)malonate | 834917-54-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-diethyl 2-(1-(2-bromophenyl)-2-nitroethyl)malonate
• 英文别名: Propanedioic acid, [(1R)-1-(2-bromophenyl)-2-nitroethyl]-, diethyl ester；diethyl 2-[(1R)-1-(2-bromophenyl)-2-nitroethyl]propanedioate
• CAS: 834917-54-3
• 化学式: C₁₅H₁₈BrNO₆
• 分子量: 388.215
• InChiKey: MEXCOGVRVDDCAH-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  98.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  o-bromonitrostyrene 、 丙二酸二乙酯 在 (1R,2R)-N1-(5,7-bis(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-N2,N2-dimethylcyclohexane-1,2-diamine 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以93%的产率得到(R)-diethyl 2-(1-(2-bromophenyl)-2-nitroethyl)malonate
  参考文献：
  名称：

  Chiral 2-aminobenzimidazole bifunctional organocatalysts: effect of di-CF3 and TFA on catalytic mechanisms

  摘要：

  (S,S)-trans-Cyclohexanediamine-5,7-di-CF3-benzimidazole (3b) was developed as a new chiral bifunctional organocatalyst and successfully applied to Michael addition of diethyl malonate to nitroolefins (up to 99%, 98% ee) under neutral condition. Systematic investigation on the catalytic mechanism revealed that the role of the guanidine moiety and the dimethylamine moiety in catalysts might be reversed with respect to Bronsted/Lewis acidic or basic functionalities, depending on the reaction conditions (neutral or TFA co-catalyst). Generally, di-CF3 group substituted 2-aminobenzimidazole catalysts in neutral condition and non-substituted 2-aminobenzimidazole catalysts in co-catalyst (TFA) condition give high chemical yield and enantioselectivity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.12.021

文献信息

• Design and Development of Bioinspired Guanine-Based Organic Catalyst for Asymmetric Catalysis
  作者：Gal Suez、Victoria Bloch、Gennady Nisnevich、Mark Gandelman

  DOI：10.1002/ejoc.201200118

  日期：2012.4

  Design, preparation, and studies of a family of new organic catalysts are presented. The design of the catalysts is inspired by the ability of DNA nucleobases to develop precise and explicit hydrogen bonds. We have shown that this phenomenon can be used to create a useful organic catalyst that demonstrates a recognition pattern similar to those of common organic substrates. A selected bifunctional

  介绍了一系列新型有机催化剂的设计、制备和研究。催化剂的设计灵感来自于 DNA 核碱基发展精确和明确的氢键的能力。我们已经表明，这种现象可用于创建一种有用的有机催化剂，该催化剂显示出类似于常见有机底物的识别模式。基于鸟嘌呤结构的选定双功能催化剂已被证明可催化 1,3-二羰基化合物与各种硝基烯烃的共轭加成，从而以良好的产率和对映选择性提供产品。
• Organocatalytic enantioselective conjugate addition of nitromethane to alkylidenemalonates: asymmetric synthesis of pyrrolidine-3-carboxylic acid derivatives
  作者：Saumen Hajra、Sk Mohammad Aziz、Rajat Maji

  DOI：10.1039/c3ra42014k

  日期：——

  A highly enantioselective nitromethane addition to alkylidene malonates catalyzed by cinchona-alkaloid derived thiourea based organocatalyst has been developed that offers a new route to the synthesis of substituted pyrrolidine-3-carboxylic acid derivatives and 3-arylpyrrolidines/pyrrolidones.

  金鸡纳生物碱衍生的对亚烷基丙二酸酯的高对映选择性硝基甲烷 硫脲 已开发出基于有机碱的有机催化剂，它为合成取代的吡咯烷-3-羧酸衍生物和3-芳基吡咯烷/吡咯烷酮提供了一条新途径。
• Physical Organic Study of Structure–Activity–Enantioselectivity Relationships in Asymmetric Bifunctional Thiourea Catalysis: Hints for the Design of New Organocatalysts
  作者：Xin Li、Hui Deng、Bo Zhang、Jiuyuan Li、Long Zhang、Sanzhong Luo、Jin-Pei Cheng

  DOI：10.1002/chem.200902430

  日期：2010.1.11

  Correlations of pKa with catalytic activity and stereoselectivity were determined and linear free energy relationships (LFERs) were observed for both pKa−log (k) and pKa−log (R/S) correlations in meta‐ and/or para‐substituted aromatic thioureas (see figure). These results provided a basis for new catalyst development and several improved catalysts were identified in our initial attempts.

  酸度效应：确定了p K a与催化活性和立体选择性之间的相关性，并在meta ‐中的p K a -log（k）和p K a -log（R / S）相关性中观察到线性自由能关系（LFER）。和/或对位取代的芳族硫脲（见图）。这些结果为新催化剂的开发提供了基础，并且在我们最初的尝试中发现了几种改进的催化剂。
• Chiral 2-aminobenzimidazole bifunctional organocatalysts: effect of di-CF3 and TFA on catalytic mechanisms
  作者：Myungmo Lee、Lei Zhang、Yohan Park、Hyeung-geun Park

  DOI：10.1016/j.tet.2011.12.021

  日期：2012.2

  (S,S)-trans-Cyclohexanediamine-5,7-di-CF3-benzimidazole (3b) was developed as a new chiral bifunctional organocatalyst and successfully applied to Michael addition of diethyl malonate to nitroolefins (up to 99%, 98% ee) under neutral condition. Systematic investigation on the catalytic mechanism revealed that the role of the guanidine moiety and the dimethylamine moiety in catalysts might be reversed with respect to Bronsted/Lewis acidic or basic functionalities, depending on the reaction conditions (neutral or TFA co-catalyst). Generally, di-CF3 group substituted 2-aminobenzimidazole catalysts in neutral condition and non-substituted 2-aminobenzimidazole catalysts in co-catalyst (TFA) condition give high chemical yield and enantioselectivity. (C) 2011 Elsevier Ltd. All rights reserved.